【7/1発効PIC/Sデータ・インテグリティ関連ガイドラインについて（２）】ASTROM通信 224号

ようやく暑さはおさまったものの雨が続いていますが、いかがお過ごしでいらっしゃいますか。

今回も前回に引き続き、2021年7月1日に発効したPIC/Sガイドライン、「GMP/GDP環境でのデータ管理とインテグリティに関する適正管理基準（PI 041-1」について見ていきたいと思います。

出典
Guidance on Data Integrity (picscheme.org)

PIC/S　GUIDANCE
GOOD PRACTICES FOR DATA MANAGEMENT AND INTEGRITY IN REGULATED GMP/GDP ENVIRONMENTS　　

7.　 一般的なデータ・インテグリティの原則と成功要因


7.1　医薬品品質システム（PQS）は、原薬や医薬品のライフサイクルのさまざまな段階を通じて
     実装され、科学的でリスクベースのアプローチの使用が促進されなければならない。

7.2　意思決定が正しく通知されることを保証し、情報が信頼できるものであることを検証する
     ために、それらの決定を通知したイベントや活動は正しく文書化されているべきである。
     そのため、適正な文書化手順（GDocPs： Good Documentation Practices）は、データ・
     インテグリティを保証するための鍵であり、正しく設計された医薬品品質システムの
     根本的な部分である。（6章参照）

7.3　GDocPsの適用は、データを記録するために使用される媒体（すなわち、物理的　対　
     電子的記録）により変わるかもしれないが、原則はどちらにも適用可能である。この章では、
     鍵となる原則を紹介し、次の章（8章、9章）では、紙ベースと電子ベースの記録保管の
     両方の文書化に関するこれらの原則を探る。

7.4　GDocPsのいくつかの鍵となるコンセプトは、ALCOAという頭文字にまとめられる。
     ALCOA ：Attributable(帰属性)、Legible(判読性)、 Contemporaneous（同時性）、
     Original(原本性)、Accurate(正確性)
     次の属性が追加されることがある。Complete（完全性）、Consistent（一貫性）、
     Enduring（耐久性）、Available（利用可能性） (ALCOA+).
     これらの期待は、イベントが適切に文書化され、データは通知された判断を裏付ける
     ために使用できることを保証する。

7.5　紙及び電子システムの両方に適用可能な基本的なデータ・インテグリティの原則(すなわち
ALCOA+).

●Attributable(帰属性)に対する要件

　記録されたタスクを実行した個人またはコンピュータ化システムを特定し、そのタスクがいつ実行されたかを特定することが可能であるべきである。これは、誰が、いつ、なぜ行ったかを知るのが重要な、訂正・削除・変更といった記録に対してなされたいかなる変更にも適用する。

●Legible(判読性) に対する要件

　全ての記録は判読可能でなければならない　ー　情報は、理解し、使用するために、読めて、はっきりしていなければならない。これは、オリジナルの記録や入力を含む、完全とみなされることが求められる全ての情報に適用する。電子データの動的性質（検索、照会、傾向分析ができる）が記録の内容と意味にとって重要な場合、適切なアプリケーションを使ってデータとやりとりする能力は、記録の利用可能性として重要である。

●Contemporaneous（同時性）に対する要件

　活動、イベント、または判断のエビデンスは、それが行われた時に記録されなければならない。この文書は、何がされたか、または、何がなぜ決められたか、すなわち、その時点で決定に何が影響したかの正確な証明として役立つべきである。

●Original(原本性)に対する要件

　オリジナルの記録は、紙（静的）または電子的（システムの複雑さによるが、たいてい動的）であっても、情報の“最初の保存”として説明されることができる。動的な状態で最初に保存された情報は、その状態のままで利用可能でなければならない。

●Accurate(正確性)に対する要件

　記録は、正確な事実の、真実の表現である必要がある。記録が正確であることの保証は、安定した医薬品品質システムのたくさんの要素を通して達成される。これは、以下のことからなる。

  • 適格性評価、キャリブレーション、維持管理、コンピュータバリデーションのような要素と関連した装置
  • 手順の要件の遵守を検証するためのデータレビュ手順を含む活動、行動を管理するためのポリシーと手順
  • 根本原因の分析、影響評価、CAPAを含む逸脱管理
  • 制定された手順の遵守や活動や判断の文書化の重要性を理解した訓練され適格性のある職員

　これらの要素は、あわせて、製品の品質について重要な決定をするために使用される科学的データを含む情報の正確性を保証することをめざす。

●Complete（完全性）に対する要件

　イベントを再現するために必須の全ての情報は、そのイベントを理解しようとした時に重要である。情報が失われたり削除されたりしないことが重要である。情報に求められる詳細さのレベルは、完全であると考えられるように設定された情報の重要性（5.4　データの重要性を参照）による。電子的に生成された完全なデータの記録は、関連するメタデータを含む。（9章参照）

●Consistent（一貫性）に対する要件

　情報は、明白な一貫性を持った論理的な方法で生成、処理、保持されなければならない。これは、データを管理したり標準化（例：年代順の配列、日付のフォーマット、測定の単位、丸めの方法、有効桁数等）したりするポリシーや手順を含む。

●Enduring（耐久性）に対する要件

　記録は、それが必要とされるだろう全ての期間中、存在するような方法で保存されなければならない。
これは、記録の保持期間を通して、消去できない/耐久性のある記録として、完全なままでアクセス可能であり続ける必要があることを意味している。

●Available（利用可能性）に対する要件

　記録は、求められる保持期間を通して、所定のリリース判断、調査、傾向分析、年次報告、監査、査察に関わらず、　レビュの責任を負う全ての該当する人員が、いつでもレビュのために利用可能で、読むことの可能なフォーマットでアクセス可能でなければならない。

7.6　もしこれらの要素が、医薬品品質システムの他の要素と共に、GMPやGDPに関連する活動の
     全ての適用可能な分野に適切に適用された場合、医薬品の品質に関する重大な決定を下す
     ために使用される情報の信頼性は、適切に保証されるはずである。

7.7　真正なコピー
7.7.1　紙の記録原本のコピー（例：分析サマリレポート、バリデーション報告等）は、一般的に、
       例えば、別々の場所で活動している会社間のコミュニケーションの目的のために、とても
       有用である。これらの記録は、別の場所（関連会社、請負業者等）から受け取ったデータ
       が、必要に応じて“真正なコピー”として保持されていること、また、“真正なコピー”
       の要件を満たさない場合(例：複雑な分析データのサマリ)は“サマリレポート”として
       使われることを保証するためにライフサイクルを通じて管理されなければならない。
7.7.2　電子的な方法で生成されたローデータは、静的なデータがオリジナルデータのインテグリティ
       を保持していることが証明された場合は、容認された紙またはPDF形式で保持されている
       ことが考えられる。しかし、データ保持の過程は、医薬品の品質に全ての面で直接または
       非直接的に影響を与える全ての活動（例：ローデータセットを復元するために必要な、以下
       のものを含む分析の記録：ローデータ、メタデータ、関連する監査証跡や結果ファイル、
       特定の分析実行のソフトウエア/システムの構成設定、処理実行の全てのデータ（方法と
       監査証跡を含む））に関する全てのデータ(メタデータを含む)を記録しなければならない。
       印刷された記録が正確な表示であることを検証するために文書化の方法の記録も必要と
       する。このアプローチは、GMP/GDPに従った記録をするには、管理上、厄介かもしれない。
7.7.3　多数の電子記録は、データと一緒に連携するために、その動的フォーマットを維持すること
       が重要である。データは、インテグリティやその後の検証のために、動的な形式を維持しな
       ければならない。データが動的なフォーマットで、どれくらい長い間保持さているべきかの
       裏付けや証明の際、リスクマネジメントの原則が利用されるべきである。
7.7.4　データを受け取るサイトでは、これらの記録(真正なコピー)は紙または電子的な形式(PDF)
       で管理されるかもしれないが、承認された品質保証の手順に従って管理されるべきである。
7.7.5  文書が、容易に検証される文書の真正性を認める方法、例えば、手書きまたは電子的署名
       の使用や、真のコピーを生成するのにバリデートされた手順に従った生成で、適切に認証
       されていることを保証するための注意が払われるべきである。
———-　表　———-

●”真正なコピー“は以下に発行され、管理されるべきか？

１．

■紙の”真正なコピー“の生成

真正なコピーを発行する会社で：

  • コピーされる文書のオリジナルを得る
  • 原本からいかなる情報も失われていないことを保証した原本の複写（photocopy）をする
  • コピーされた文書の真正性を検証し、“真正なコピー”として新しいコピーにサインと日付を付ける
    “真正なコピー”は、これで所定の受け手に送ることができる。

■電子文書の”真正なコピー“の生成

全ての必要なメタデータを含む電子記録の”真正なコピー“は、電子的方法（電子ファイルコピー）により生成されなければならない。メタデータの損失の可能性がある場合、電子データのPDFの生成は、禁止されるべきである。
“真正なコピー”は、これで所定の受け手に送ることができる。　　　　　

発行された全ての”真正なコピー“(ソフト/ハード)の配布リストが保持されなければならない。　　　　　

■記録のレビュ時にチェックされるべき特定の要素

  • 真正なコピーの生成手順を検証し、生成方法が適切に管理されていることを保証せよ。
  • 発行された真正なコピーが原本と同一（完全で正確である）ことをチェックせよ。スキャン された画像に改竄がないことを確認するために、コピーされた記録は、原本の記録と 照合されるべきである。
  • データ・インテグリティを保証するために、スキャンもしくは保存された記録が保護されて いることをチェックせよ。
  • 紙の記録のスキャンと“真正なコピー”の生成の検証の後
    • 配布目的(例：顧客への送付)で真正なコピーが生成される場合、どの原本から真正なコピーが生成されたか
      配布目的(例：顧客への送付)で真正なコピーが生成される場合、どの原本からスキャン画像が生成されたか
      は、記録所有者により、それぞれの保管期間中、保持されるべきである。
    • 文書保持を助けるために真正なコピーが作成される場合、スキャン画像が生成されているなら、オリジナルの記録の代わりにコピーを保持することは可能かもしれない。

２．

真正なコピーを受け取った会社で：
紙、スキャンされたコピー、電子ファイルは、適正な文書管理手順に従ってレビュされファイルされるべきである。
文書は、真正なコピーであってオリジナルの記録でないことが明確に示されるべきである。

■記録のレビュ時にチェックされるべき特定の要素

  • 受領した記録が適切にチェックされ保持されていることをチェックせよ。
  • “真正なコピー”の真正性を検証するためのシステムが整備されるべきである。
    例：正しい署名者の検証

————————–
7.7.6　“真正なコピー”の生成と移動や、データ・インテグリティの管理のための責任に取り組む
       ために品質協定を結ぶべきである。“真正なコピー”の発行と管理をするシステムは、
       安定していてデータ・インテグリティの原則を満たすことを保証するために契約の
       委託者と受託者により監査されるべきである。

7.8　サマリレポートのリモートでのレビュの限界
7.8.1　サマリレポート内のデータのリモートでのレビュは一般的に必要である。しかし、データ・
       インテグリティの適切な管理を可能にするためにリモートのデータレビュの限界が十分
       に理解されるべきである。
7.8.2　データのサマリレポートはしばしば物理的に離れた製造場所、販売承認取得者、利害
       関係者の間で提供される。しかし、サマリレポートはその性質や重要な裏付けデータの
       点で本質的に限界があり、メタデータはしばしば含まれていないので、オリジナルデータ
       はレビュできない。
7.8.3　従って、サマリレポートは、必須ではあるが、データ転送のプロセスの1つの要素として
       みなされ、利害関係者や査察当局はサマリレポートのデータだけに全幅の信頼を置か
       ない。
7.8.4　サマリレポートを受け入れる前に、供給者の品質システムとデータ・インテグリティの原則
       の遵守は検証されるべきである。通常、机上やそれと類似のアセスメントの使用を通じ
       て、データ・インテグリティの原則の遵守を判断することは受け入れられないし、不可能で
       ある。
7.8.4.1　外部の組織については、品質リスクマネジメントの観点から重要と考えられる場合は、
         オンサイトの監査を通じて判断されるべきである。監査は、その会社によって生成され
         たデータの精密さを保証し、サマリデータやレポートを生成し配布するのに使用されて
         いるメカニズムのレビュを含むべきである。
7.8.4.2　同じ組織の異なる場所間でサマリデータが配布される場合、供給しているサイトの
         データ・インテグリティの原則の遵守の評価は、他の方法（例：会社の手順の遵守の
         エビデンス、内部監査レポート等）を通じて判断が行われてもよいかもしれない。
7.8.5　サマリデータは、合意された手順に従って準備され、レビュされ、原本のあるサイトの
       権限のある職員によって承認されるべきである。サマリは、サマリの真正性と正確性を
       言明したオーソライズド・パーソンによるサイン付の宣言を伴うべきである。サマリレポート
       の生成、移動、検証に関する取り決めは、品質/技術協定の中で取り扱われるべきである。

8. 紙ベースのシステム固有のデータ・インテグリティの留意事項
8.1　医薬品品質システム（PQS）の体制と、ブランクフォーム/テンプレート/記録の管理
8.1.1　紙ベースの文書の効果的な管理は、GMP/GDPの重要な要素である。従って、文書システム
       はGMP/GDP要件に合うように設計され、文書や記録のインテグリティが維持されるように
       効果的な管理を保証するべきである。
8.1.2　紙の記録は、データのライフサイクルを通じて管理され、帰属性、判読性、同時性、原本性、
       正確性、完全性、一貫した耐久性（消去できない/耐久性のある）、利用可能性（ALCOA+）
       が維持されなければならない。
8.1.3　適正な文書管理基準の概要を述べた手順と文書管理の手筈は、PQSの中で利用可能で
       あるべきである。これらの手順は、データ・インテグリティの手順がいかにデータのライフ
       サイクルを通じて維持されるかについて、以下のことを含み詳細に記述すべきである。

  • 文書の原本と手順の生成、レビュ、承認
  • データを記録するために使用されるテンプレートの生成、配布、管理（原本、ログ等）
  •   記録に関する検索と障害回復手順
  • 文書のコピーの保証に特に重点を置いた、通常使用する文書の生成手順　例：SOP      
    とブランクフォームが、管理され、トレース可能な方法で、発行され、照合される
  • 紙ベースの文書の完成、個々のオペレータの特定方法の記述、データ入力フォーマット、録の修正、正確性・真正性・完全性の所定のレビュ
  • 記録のファイリング、検索、保持、アーカイブ、廃棄

8.2 記録の管理の重要性
8.2.1　GMP/GDPの作業にとって記録は重要であり、以下のことを保証するために記録の管理が
       必要である：

  • 実施された活動のエビデンス
  • GMP/GDP要件の遵守のエビデンスと、会社のポリシー、手順、作業指図
  • 医薬品品質システム（PQS）の効果
  • トレーサビリティ
  • 手順の信頼性と一貫性
  • 製造された医薬品の正しい品質特性のエビデンス
  • 苦情や回収の場合、記録は調査目的で使用できる
  • 逸脱や試験の不合格の場合、記録は、効果的な調査の完了のために重要である

8.3　テンプレートの記録の生成、配布、管理
8.3.1　原本文書の管理・監督は、誰かの不適切な使用や、‘通常の方法による’（すなわち専門家に
　　　 よる不正技術の使用を必要としない）記録の偽造が、許容可能なレベルまで減らされることを
       保証するために必要である。次章の期待は、品質リスクマネジメントアプローチを使い、リスク
       と記録されたデータの重要性を考慮して実施されるべきである。

8.4　記録の生成、配布、管理の期待
———-　表　———-

●生成

１－期待

  • 全ての文書は、ユニークな識別番号（バージョン番号を含む）を持ち、チェックされ、承認され、サインされ、日付がつけられなければならない。
  • 管理されていない文書の使用は、部門の手順で禁止されるべきである。一時的な記録の手順の使用(例：紙の廃棄)は禁止すべきである。

１－期待を満たさない場合の潜在的なリスク/チェック項目

  • 管理されていない文書は、トレーサビリティがなく、これらの文書が廃棄されたり破壊されたりして、重要なデータの削除や紛失の可能性を増す。さらに、管理されていない記録は、重要なデータを正しく記録するために設計されていないかもしれない。
  • 管理されていない記録を偽造することはより簡単かもしれない。
  • 記録の手順の一次的な使用は、データの削除につながる可能性があり、これらの一時的な記録は保持に関して明確に記述されていない。
  • もし、記録が管理なく作成され、アクセスされたら、イベントの発生した時に記録がされていない　可能性がある。
  • バージョンの管理や発行の管理がされていなければ、廃止されたフォームを使用するリスクがある。

２－期待

  • 文書のデザインは、手書きのデータ入力のために十分なスペースが提供されるべきである。

２－期待を満たさない場合の潜在的なリスク/チェック項目

  • 手書きのデータは、もし、データの入力のためのスペースが十分でないと、はっきりしていなかっ　たり読めなかったりする可能性がある。
  • 文書は、コメント（例：記述エラーの場合、エラーの取り消し、イニシャルと日付、説明のための　十分なスペースがあるべきである）のための十分なスペースを提供するためにデザインされるべきである。
  • もし、文書の完成のために、文書に追加のページが加えられたら、メインの記録のページに追加されたページ数と参照が明確に文書化されサインされなければならない。
  • 例えば、目的からはずれ、印刷されたページの裏側に記録されることを防ぐために、全ての必要　なデータを追加するために文書のフォーマットに十分なスペースが提供されるべきであり、データ　は文書にやみくもに記録されるべきでない。

３－期待

  • 文書のデザインは、どのデータが入力されるものかを明確にするべきである。

３－期待を満たさない場合の潜在的なリスク/チェック項目

  • 不明確な指図は、一貫性のない/間違ったデータの記録につながるかもしれない。
  • 適正なデザインは、全ての重要なデータが記録されていることを保証し、入力が同時で、耐久性　（消去できない/耐久性のある）があって完全であることを保証する。
  • 文書は、重要なデータがうっかり省略されるリスクを最小化するために、操作手順や関連する　SOPと同じ順番で情報が記録されるように構築されるべきである。

４－期待

  • 文書は適切なバージョン管理を保証する状態で保管されるべきである。
  • 原本とコピーを区別するために、原本の文書は目立つマークを含むべきである。(例：うっかりした使用を防ぐための色のついた紙やインクの使用)
  • 原本の文書（電子フォーム）は、許可のない変更やうっかりした変更を防ぐべきである。
  • 例えば電子的に保管されているテンプレートについて、以下の予防策がとられるべきである。
    • 原本テンプレートへのアクセスは管理されるべきである。
    • バージョンの作成と更新に関する手順の管理は、明確で、実用的に適用され、確認される　　べきである。
    • 原本の文書は、許可のない変更を防ぐ方法で保管されるべきである。

４－期待を満たさない場合の潜在的なリスク/チェック項目

  • 不適切な保管状態は、許可されていな修正、期限切れやドラフトの文書の使用を許し、原本の紛失を引き起こす可能性がある。
  • 場合により事前の適切な教育による実装の手順と効果的なコミュニケーションは、文書と同じくらい重要である。

●配布と管理

１－期待

  • 更新されたバージョンは、タイミングよく配布されるべきである。
  • 廃止された原本の文書やファイルは保管され、それらのアクセスは制限されるべきである。
  • 全ての発行済で未使用の物理的文書は検索されたり照合されたりするべきである。
  • 品質部門により許可された場合、文書の回収されたコピーは破棄されてよい。しかし、承認された  文書の原本のコピーは保管されるべきである。

１－期待を満たさない場合の潜在的なリスク/チェック項目

  • もし、廃止されたバージョンが使用可能な状態の場合、誤って使用されるリスクがあるかもしれない。

２－期待

  • 文書の発行は、以下の条件を含む文書化された手順により管理されるべきである。
    •  誰が、いつコピーを発行したかの詳細
    •  文書の承認されたコピーを識別する明確な方法　例：安全なスタンプの使用、または、作業場所で利用不可能という紙の色の規則、または、他の適切なシステム
    •  現在承認されているバージョンのみが使用可能であることを保証すること
    •  発行されたそれぞれのブランク文書にユニークな識別子を割り当てることと、記録簿での各文書の発行の記録
    • すべての配布されたコピーへのナンバリング（例：コピー2/2）と、綴じられた帳簿内での発行ページの連番
    • ブランクのテンプレートの追加コピーを再発行する場合、全ての配布されたコピーは保管され、追加のコピーの必要性の正当な理由と承認が記録される(例：オリジナルのテンプレートの記録が傷んだ)と共に、再発行に関する管理された手順に従うべきである。
    • 重要なGMP/GDPのブランクフォーム(例：ワークシート、ラボノート、バッチレコード、管理記録)は、 記録の正確性と完全性を保証するために、次の使用で照合されるべきである。
    • 記録以外の文書（例：手順）のコピーが持ち出し禁止で印刷される場合、文書上にしるされた生成のタイムスタンプと、短期の有効性の提示により、照合は必要ないかもしれない。

２－期待を満たさない場合の潜在的なリスク/チェック項目

  • 安全な方法が使用されないと、テンプレートの複写（photocopy）やスキャン（ユーザに別のテンプレートのコピーを与える）がされた後にデータの書き直しや改ざんをされるリスクがある。
  • 廃止されたバージョンが意図的または間違って使用される可能性がある。
  • 変則のデータ入力により記入された記録は、新しく書き直された記録のテンプレートにより置き　換えられる可能性がある。
  • 全ての未使用のフォームは、理由が報告され、表面を汚してボツにするか破棄するか、安全なファイルに戻されるべきである。
  • 文書の参照用コピーは、生成日、有効期間と持ち出し禁止で正式なコピーでないという明確な表示(例：印刷時に”管理外“と表示)が示されていることをチェックせよ。

————————–

8.4.1　全ての承認された原本の文書（SOP、フォーム、テンプレート及び記録）のインデックスは、
       医薬品品質システムの中で保持されなければならない。このインデックスは、少なくとも
       以下の情報を含む、テンプレートの記録のタイプについて述べられなければならない：
       タイトル、バージョン番号を含む参照番号、ロケーション（例：文書のデータベース、発効日、
       次回のレビュ日付等）

8.5　ユースポイントでの記録の使用と管理
8.5.1　記録は、ユースポイントでオペレータが利用可能であり、これらの記録を扱うために適切な
       管理が行われていなければならない。これらの管理は、記録の損傷や紛失を最小化し、
       データ・インテグリティを保証するために実行されなければならない。必要な場合、汚れ
       （例：原材料により濡れたり、着色したりする）ことから記録を守るための方法がとられ
       なければならない。
8.5.2　記録は、これらのエリアの中で、文書化された手順に従って、指定された人または手順に
       より、適切に管理されなければならない。

8.6　記録の記入
8.6.1　以下に挙げられた項目は、記録が適切に記入されていることを保証するために管理されな
　　　 ければならない。
———-　表　———-
１－期待

  • 手書きの記入は、業務を実行した人により作成されなければならない。
  • 文書内の未使用の空欄は、斜線を入れ、日付とサインがされなければならない。
  • 手書きの記入は、明瞭で判読できるようにされなければならない。
  • 日付欄の記入は、製造所で定義されたフォーマットでされなければならない。（例：dd/mm/yyyy　またはmm/dd/yyyy）

１－期待を満たさない場合の潜在的なリスク/チェック項目

  • 手書きは、同じ人物により一貫して記入されていることのチェック
  • 記入が判読でき、明瞭であることのチェック（例：はっきりしている：未知の記号や略語を含まないこと。例えば前と同じ（“）の記号）
  • 記録された日付の完全性のチェック
  • 記録の正しいページ数と、全てのページの存在のチェック

２－期待

  • 操作に関する記録は、同時に完成されるべきである。

２－期待を満たさない場合の潜在的なリスク/チェック項目

  • 記録が、それらが使用されるエリア周辺内で利用可能であることを検証せよ。すなわち、査察官　は、作業場所で一連の記録がされることを期待するべきである。もしフォームがユースポイントで　利用可能でなければ、作業者が発生時に記録を作成する余地はないだろう。

３－期待

  • 記録は耐久性（消去できない）がなければならない。

３－期待を満たさない場合の潜在的なリスク/チェック項目

  • 手書きされた記入がインクであり、（保持期間中）消せず、ぼけたり、あせたりしないことをチェックせよ。
  • 記録がペンの使用の前に鉛筆で書かれていないことをチェックせよ。（重ね書き）
  • システムからある種の紙への印刷物は、時間と共にあせることに注意せよ。例：感熱紙　
    これらの消せないサインと日付が書かれた真正なコピーが作られ保管されるべきである。

４－期待

  • 記録は、作成者に帰属可能なユニークな識別子を使い、サインと日付が書かれているべきである。

４－期待を満たさない場合の潜在的なリスク/チェック項目

  • 標準化された印刷された文書ではなく、管理され、最新でユニークなサインとイニシャルのログが　書かれていることを確認せよ。
  • 手順が時間と共に発生する場合、全ての重要な入力は、ページや工程の終わりにサインされるのではなく、時間と共にサインされ、日付が書かれていることを保証せよ。
  • 個人の印鑑の使用は一般的には勧められないが、もし使用する場合は、利用が管理されていなければならない。個人と個人の印鑑のトレーサビリティを明確に示す記録がなければならない。個人の印鑑の使用は、所有者により日付が書かれ、許容できると判断されなければならない。

————————–

8.7　記録の訂正
記録の訂正は、完全なトレーサビリティが維持される方法でされなければならない。
———-　表　———-
記録はどのように訂正されるべきか？
１－期待

  • 変更されるものの1本線による取り消し
  • 適宜、訂正の理由が明確に記録され、重要な場合は検証されること
  • 変更を行った人のイニシャルと日付

１－記録をレビュした時にチェックされるべき特定の要素

  • オリジナルのデータが読めて、不明確になっていないことをチェックせよ。（例：修正液の使用に　より目立たなくされていないこと。上書きは認められない）
  • 重要な入力データに変更がされた場合、変更の正当な理由が記録され、変更を裏付けするエビデンスが利用可能であることを確認せよ。
  • 記録の中の、説明のつかない記号や入力をチェックせよ。

２－期待

  • 訂正は、消えないインクで行われなければならない。

２－記録をレビュした時にチェックされるべき特定の要素

  • 手書きされた記入がインクであり、（保持期間中）消せず、ぼけたり、あせたりしないことをチェックせよ。
  • 記録がペンの使用の前に鉛筆で書かれていないことをチェックせよ。（重ね書き）

————————–

8.8　記録の検証（第二のチェック）
———-　表　———-
いつ、誰が記録の検証を行うべきか？

１－期待

  • 重要な工程のステップの記録（例：ロットの記録の中の重要なステップ）は
    • 作業が行われた時に、独立し、指名された職員によりレビュされ署名されるべきである。　また
    • 品質保証部門に送られる前に、製造部門内の承認された職員によりレビュされること
    • 製造されたロットがリリースまたは出荷される前に品質保証部門 (例：オーソライズド・パーソン/クオリファイド・パーソン) によりレビュされ、承認されるべきである。
      重要でない工程のステップのロットの製造記録は、一般的に、承認された手順により、製造部門の職員によりレビュされる。

  試験のステップに関する試験室の記録は、試験の完了後に、指名された職員（例：第二の分析者）によりレビュされること。レビュ者は、全ての入力、重要な計算をチェックし、データ・インテグリティの原則に従って試験結果の信頼性の適切なレビュを行うことが期待される。
重要な試験の判断が一人の職員(例：寒天培地プレート上の微生物のコロニーの記録)によってされる場合、追加の管理が考慮されるべきである。第二のレビュは、リスクマネジメントの原則に従って必要とされるべきである。
一部のケースでは、このレビュはリアルタイムで実施されることが求められるかもしれない。重要なデータの検証の適切な電子的手段（例：データの写真の画像をとる）は、許容可能な代替手段になるかもしれない。
この検証は、製造関連の業務や作業の後に実施され、適切な職員により、サインされるか、頭文字が記され、日付が書かれていなければならない。
部門のSOPには、文書のレビュのための手順が記述されていなければならない。

１－記録のレビュ時にチェックされるべき特定の要素

  • 関連する活動が実施された時に関連する記録が的確な職員により直ちに利用可能であることを保証するために、製造エリア内での製造記録の取扱に関する手順を検証せよ。
  • 作業中に行われたいかなる第二のチェックも、適切に資格要件を満たし、独立した職員（例：製造管理者またはQA）により実施されたことを検証せよ。
  • 文書が製造部門の職員によりレビュされ、それから、作業の完了後に品質保証部門の職員により  レビュされたことをチェックせよ。

２－期待

  • 現在の承認されたテンプレートを使って、全ての欄が正しく完成されていて、そのデータとデータの許容範囲がじっくりと対比されているかをチェックせよ。
  • 8.6章のチェック項目1,2,3,4と、8.7章のチェック項目1,2をチェックせよ。

２－記録のレビュ時にチェックされるべき特定の要素

  • 査察官は、手順の適格性を判断するために、マニュアルで入力されたデータのレビュに関する会社の手順をレビュすべきである。
  • 第二のチェックの必要性と範囲は、品質リスクマネジメントの原則、生成されるデータの重要性に  基づくべきである。
  • データの第二のレビュが使用された全ての式の計算検証を含んでいることをチェックせよ。
  • 正しいデータが計算のために複写されていることを確認するためにオリジナルデータを調査せよ  （可能であれば）。

————————–

8.9.1　いくつかの非常にシンプルな電子システム（例：秤、pH計）またはデータを蓄積しないシンプルな
　　　 処理装置は、直接印刷して紙の記録を生成する。これらのタイプのシステムと記録は、（再）加工
       や電子の日付/タイムスタンプの変更によるデータの提出に影響を与える機会が限定される。
       これらの状況では、オリジナルの記録は、例えばサンプルID、ロットナンバーなどのトレーサ
       ビリティを保証するために、記録や情報を作成した職員によりサインと日付が書かれるべきで
       ある。これらのオリジナルの記録は、ロットの製造記録や試験記録に添付されるべきである。
8.9.2　これらの記録の耐久性を保証するために検討がされるべきである。(8.6.1章を見よ)

8.10　文書の保持（記録の保持要件の特定と、アーカイブした記録）
8.10.1　記録の各タイプの保持期間は、GMP/GDP要件により指定された期間を（少なくとも）満たさ
　　　　ないといけない。より長い保管期間を規定しているかもしれない他の地域や国の法律が考慮
　　　　されるべきである。
8.10.2　記録は、内部的に、または、品質協定の対象となる外部のストレージサービスを使用すること
　　　　により、保持されることができる。この場合、データの中心位置が特定されなければならな い。
　　　　保持するシステム/設備/サービスが適切で、残存リスクが理解されていることを証明するため
　　　　に、リスクアセスメントが利用可能でなければならない。
———-　表　———-
どこで、どのように記録がアーカイブされるべきか？
１－期待

  • システムは記録のアーカイブに関しさまざまな段階の記述が整えられるべきである。（アーカイブ　ボックスの確認、ボックスによる記録のリスト、保持期間、アーカイブする場所等）
  • アクセスや、記録の再生はもちろん、ストレージでの管理に関する指図が定められるべきである。
  • システムは、全てのGMP/GDP関連の記録が、GMP/GDP要件を満す期間中保持されることを保証　すべきである。

１－記録をレビュした時にチェックされるべき特定の要素

  • アーカイブされた記録を検索するために実装されているシステムが効果的でトレース可能であることをチェックせよ。
  • 記録が規則に従った方法で保存され、簡単に識別可能かどうかをチェックせよ。
  • 記録が規定された場所にあり、適切に保護されていることをチェックせよ。
  • 保管された記録の完全性を保証するために、アーカイブされた文書のアクセスが、オーソライズド・パーソンに限定されていることをチェックせよ。
  • アクセスした記録の存在と記録の回復についてチェックせよ。
  • 使用される保管方法は、必要な時に効果的な文書の検索が可能でなければならない。

２－期待

  • 全ての品質記録のハードコピーは下記のようにアーカイブされるべきである。
    • 損害や紛失を防ぐための安全な場所
    • 簡単にトレースできて、検索できる方法
    • 記録がアーカイブ期間中、耐久性があることを保証する方法

２－記録をレビュした時にチェックされるべき特定の要素

  • 外注したアーカイブ作業に関して、品質協定が整っているか、また、保管場所が監査されているかをチェックせよ。
  • 文書が、全てのアーカイブ期間中、判読可能で利用可能であることを保証するためのなんらかの　アセスメントがあることを保証せよ。
  • 印刷物が永久的でない（例：熱転紙）場合、非永久の原本と一緒に検証された（“真正な”）コピー  が保持されなければならない。
  • 使用される保管方法は、必要な時に効果的な文書の検索が可能かどうか検証せよ。

３－期待

  • 全ての記録は、下記の原因による損失や破壊から保護されなければならない。
    • 火事
    • 液体（例：水、溶剤、緩衝液）
    • ネズミ
    • 湿度　など
    • 記録を修正、破壊、差し替えるかもしれない権限のない職員のアクセス

３－記録をレビュした時にチェックされるべき特定の要素

  • 記録を保護するためのシステムがあるかチェックせよ。（例：害虫駆除、スプリンクラー）
    注：スプリンクラーシステムは、その場所の安全要求に従って実装されているべきである。しかし、スプリンクラーシステムは文書への損害を防ぐために設計されているはずである。（例：文書　が水から保護されていること。）
  • 記録への適切なアクセスコントロールについてチェックせよ。

————————–

8.11　オリジナルの記録または真正なコピーの廃棄
8.11.1　記録の廃棄に関する文書化された手順は、定められた保持期間後に、正しい記録の原本や
        真正なコピーが廃棄されることを保証するために準備が整っていなければならない。システム
        は、偶然に現在の記録が破棄されないことと、過去の文書がうっかり現在の記録の中に戻る
        （例：過去の記録が、現在の記録と混同/混合する）ことがないことを保証すべきである。
8.11.2　部門の方針に従って、適切でタイムリーなアーカイブまたは不要となった記録の破壊を証明する
        ために、記録/登録が、利用可能でなければならない。
8.11.3　間違った文書を消去するリスクを減らすための手段が整えられていなければならない。記録の
        削除が許されたアクセス権限は数人の職員に限定されるべきである。

まとめ

長い。。。とげっそりされたかもしれません。

いろいろ注意しないといけない点がありますが、個人的には、真正なコピー(7章)が気になりました。『これは原本のコピーです』と言うには、クリアすべき条件があり、安易な対応はできないと感じました。

  • 真正なコピーの要件を満たさないものはサマリレポートとして扱わないといけない(7.7.1章)が、サマリレポートのリモートでのレビュに限界があること(7.8章)
  • 電子的に作られたローデータを真正なコピーとして紙やPDFで保管するには、ローデータだけでなく関連するデータも保持する必要があり、相当面倒であること(7.7.2章)

など、注意が必要だと思います。

　

弊社サービスのプロス

https://drmarketing.jp/cch/73/640/3/377/501330/ee3281

★ブログ毎日更新中！

◆ PROS.社長の滋養強壮ブログ

◆ プロス橋本のブログ

【発行責任者】

株式会社プロス　『ASTROM通信』担当　橋本奈央子 hashimoto@e-pros.co.jp

※本記事は株式会社プロスの許可を得て転載しております。

Related post

Comment

  1. I truly appreciate this article post.Much thanks again. Want more.

  2. Great blog article.Thanks Again. Really Great.

  3. Thanks for sharing, this is a fantastic article. Awesome.

  4. Muchos Gracias for your blog.Much thanks again. Fantastic.

  5. Muchos Gracias for your blog article.Really thank you! Awesome.

  6. I appreciate you sharing this post.Thanks Again. Great.

  7. Enjoyed every bit of your article.Really thank you! Really Cool.

  8. Thanks again for the article.Much thanks again. Really Cool.

  9. I think this is a real great blog.Really thank you! Really Great.

  10. Wonderful job. Your stitches look very uniform. I love to crochet too. 🙂

  11. Thanks a lot for the blog post.Really looking forward to read more. Great.

  12. wow, awesome blog.Really thank you! Want more.

  13. I truly appreciate this blog post.Really thank you! Awesome.

  14. Very good article post. Keep writing.

  15. Hey there! I just wish to offer you a huge thumbs up for the excellent information you’ve got right here on this post.I am returning to your blog for more soon.

  16. online gambling slots games free slots online

  17. I will right away grab your rss feed as I can’t find your e-mail subscription link or newsletter service. Do you have any? Kindly let me know so that I could subscribe. Thanks.

  18. These are actually great ideas in regarding blogging. You have touched somenice factors here. Any way keep up wrinting.Here is my blog post: game mega888 online

  19. med pharmacy canada pharmacy safedrg – canadian pharmacy world coupon

  20. This is one awesome blog. Awesome.

  21. Enjoyed every bit of your blog. Really Great.

  22. Really informative post.Thanks Again. Great.

  23. Looking forward to reading more. Great post. Will read on…

  24. I like the valuable information you supply for your articles.I’ll bookmark your blog and test again herefrequently. I’m quite sure I will be informed plenty of new stuff right right here!Best of luck for the next!

  25. I cannot thank you enough for the post.Thanks Again. Keep writing.

  26. Amazing! This blog looks exactly like my old one! It’s on a totally different topic but it has pretty much the same layout and design. Outstanding choice of colors!

  27. This looks absolutely perfect. All these tinny details are made with lot of background knowledge. I like it a lot. This was a useful post and I think it is rather easy to see from the other comments as well that this post is well written and useful.

  28. vegas slots online vegas slots online online slot games

  29. Major thanks for the blog.Really looking forward to read more. Will read on

  30. Thanks a lot for the article post.Really looking forward to read more. Will read on…

  31. Im thankful for the article post. Fantastic.

  32. Hey, thanks for the blog post.Much thanks again. Great.

  33. Very good blog post.Thanks Again. Great.

  34. Thanks for the blog post.Thanks Again.

  35. Great, thanks for sharing this blog article.Thanks Again. Really Great.

  36. This is one awesome post.

  37. ivermectin canada ivermectin for humans – ivermectin oral solution

  38. Im grateful for the blog article.Much thanks again. Great.

  39. Thank you ever so for you post.Thanks Again. Keep writing.

  40. Amazing information, Appreciate it!how to write a good introduction paragraph for an essay help me write my thesis statement help on writing a personal statement

  41. pharmacy technician online programs cvs pharmacy order online

  42. My brother recommended I might like this blog.He was totally right. This post actually made my day.You cann’t imagine simply how much time I had spent for this info!Thanks!

  43. Major thanks for the post.Really thank you! Much obliged.

  44. Hey, thanks for the article.Really thank you! Awesome.

  45. Say, you got a nice post. Really Great.

  46. Thanks-a-mundo for the post.Really looking forward to read more. Awesome.

  47. I cannot thank you enough for the article.Really looking forward to read more. Keep writing.

  48. ınstagram takipçi satın al işlemi yapmak için en güvenilir adres.

  49. Oh my goodness! an amazing article dude. Thanks Nonetheless I am experiencing issue with ur rss . Don’t know why Unable to subscribe to it. Is there anyone getting an identical rss downside? Anyone who knows kindly respond. Thnkx

  50. Really enjoyed this article post.Much thanks again. Keep writing.

  51. I think this is a real great post.Really thank you! Really Great.

  52. I think this is a real great blog post.Thanks Again. Really Great.

  53. Im grateful for the blog.Really thank you! Awesome.

  54. Im obliged for the post.Really thank you! Great.

  55. Very neat post.Really looking forward to read more. Cool.

  56. Fantastic article.Much thanks again. Keep writing.

  57. I really like and appreciate your article.Really looking forward to read more. Will read on…

  58. Really informative article.

  59. Fastidious answer back in return of this query with firm arguments and explaining all on the topic of that.

  60. Great, thanks for sharing this post. Really Cool.

  61. Really appreciate you sharing this blog post. Really Great.

  62. It laborious to seek out knowledgeable folks on this matter, but you sound like you already know what you are talking about! Thanksclick this link now

  63. aricept for dementia side effects of donepezil donepezil hcl side effects

  64. Hurrah! At last I got a blog from where I can genuinelyget helpful facts concerning my study and knowledge.

  65. I truly appreciate this article post.Much thanks again. Cool.

  66. I am so grateful for your blog article.Really thank you! Fantastic.

  67. Very informative article post.Really looking forward to read more. Really Great.

  68. Very good post.Really thank you! Really Great.

  69. Im thankful for the blog post.Really thank you! Great.

  70. Great blog article.Thanks Again. Really Cool.

  71. Really enjoyed this blog post.Really looking forward to read more. Keep writing.

  72. I really like and appreciate your post. Really Great.

  73. A round of applause for your article post.Much thanks again. Cool.

  74. Thank you ever so for you post.Really thank you! Want more.

  75. Thanks for sharing, this is a fantastic post.Really looking forward to read more. Keep writing.

  76. Thank you for your post. Awesome.

  77. Great, thanks for sharing this blog article.Much thanks again. Cool.

  78. Major thanks for the article. Really Great.

  79. Very good blog article.Much thanks again. Cool.

  80. I really enjoy the post.Thanks Again.

  81. Wow, great article post.Really thank you! Really Great.

  82. Thanks so much for the article.Really thank you! Awesome.

  83. Great blog article.Much thanks again. Much obliged.

  84. Very good article.Really looking forward to read more. Much obliged.

  85. Thanks a lot for the article.Really looking forward to read more.

  86. Really appreciate you sharing this article post.Thanks Again. Really Cool.

  87. I am so grateful for your post.Much thanks again. Awesome.

  88. I truly appreciate this blog post.Really thank you! Fantastic.

  89. I cannot thank you enough for the blog post.Thanks Again. Fantastic.

  90. Wow, great blog. Really Great.

  91. I truly appreciate this article post.Thanks Again. Really Cool.

  92. Thanks for finally talking about > Custom Design PlaygroundCompleted for Gabriella Park

  93. Thanks a lot for the blog post.Really looking forward to read more. Awesome.

  94. Im grateful for the article.Really thank you! Want more.

  95. Thanks so much for the article post.Much thanks again. Fantastic.

  96. Really appreciate you sharing this article post.Thanks Again. Awesome.

  97. Igjerr – annotated bibliography mla maker Pobtit vzrqne

  98. Awesome article post. Cool.

  99. Enjoyed every bit of your blog post.Thanks Again. Really Great.

  100. This is one awesome blog.Really thank you! Really Cool.

  101. Say, you got a nice blog.Really looking forward to read more. Want more.

  102. slots free play slots online slots online

  103. Thanks for the blog.Really thank you! Really Cool.

  104. scoliosisHi friends, its fantastic paragraph concerning teachingand entirely explained, keep it up all the time.scoliosis

  105. This is a very good tip particularly to those fresh to the blogosphere. Short but very accurate informationÖ Appreciate your sharing this one. A must read article!

  106. This post gives clear idea for the new viewers of blogging, that in fact how to do blogging.

  107. I appreciate you sharing this article.Much thanks again. Fantastic.

  108. I really like and appreciate your article.Much thanks again. Fantastic.

  109. I really liked your blog article.Much thanks again. Cool.

  110. Im grateful for the blog article.Really thank you! Will read on…

  111. Las 7 mejores publicaciones HTML tipográficas para su sitio

  112. Really appreciate you sharing this post.Really looking forward to read more. Great.

  113. Very neat article post.Thanks Again. Really Cool.

  114. I love what you guys tend to be up too. This sort of clever work and coverage! Keep up the awesome works guys I’ve added you guys to my personal blogroll.

  115. I blog frequently and I really thank you for your content. This great article has truly peaked my interest. I’m going to book mark your blog and keep checking for new information about once a week. I subscribed to your Feed as well.

  116. Great post. I was checking continuously this blog and I am impressed! Extremely useful info particularly the last part 🙂 I care for such information much. I was looking for this certain information for a long time. Thank you and best of luck.

  117. Very nice info and straight to the point. I don’t know if this is really the best place to ask but do you people have any thoughts on where to employ some professional writers? Thank you 🙂

  118. Appreciate you sharing, great blog post.Thanks Again. Fantastic.

  119. Heya! I just wanted to ask if you ever have any trouble with hackers? My last blog (wordpress) was hacked and I ended up losing several weeks of hard work due to no backup. Do you have any methods to protect against hackers?

  120. Major thanks for the blog.Really thank you! Will read on…

  121. Hey, thanks for the post.Really looking forward to read more. Really Cool.

    • zenithund solar tracker
    • 2023.10.15

    Great post.Thanks Again.

    • zenithund solar tracker slew drive
    • 2023.10.16

    Appreciate you sharing, great article.Much thanks again. Much obliged.

  124. Very informative post.Really looking forward to read more. Cool.

  125. Really enjoyed this blog.Really thank you!

  126. I really enjoy the article post.Really thank you! Will read on…

  127. Thank you ever so for you blog.Really thank you! Really Great.

  128. Hi there, this weekend is fastidious in support of me,as this occasion i am reading this impressiveinformative piece of writing here at my home.

  129. Great blog article.Much thanks again. Great.

  130. Very neat article.Really looking forward to read more. Fantastic.

  131. I really liked your blog post.Really thank you! Fantastic.

  132. Thank you, I’ve recently been looking for information about this topic for along time and yours is the greatest I have found out so far.However, what concerning the conclusion? Are you certain in regards tothe source?

  133. A big thank you for your post.Really thank you! Cool.

  134. Hi mates, pleasant piece of writing and nice urging commented here, I am truly enjoying bythese.

  135. chloroquine hydrochloride chloroquine phosphate online

  136. I appreciate you sharing this article.Thanks Again. Fantastic.

  137. There’s certainly a great deal to know about this issue. I really like all of the points you have made.

  138. Hi my family member! I wish to say that this post is awesome, great written and comewith almost all important infos. I’d like to look extra posts like this .Look into my blog post – orange lake resort

  139. Wow, great blog.Thanks Again. Keep writing.

  140. XOMTerese Return To Castle Wolfenstein G Save Game Cannot Open File For Saving sentemul2007 64 bitWadeNazari Forzahorizon2Pccrack15 Stacia

  141. The sketch is attractive, your authored subject matter stylish.

  142. Really informative blog article. Will read on…

  143. A round of applause for your blog post. Cool.

  144. I really enjoy the article post.Thanks Again. Really Cool.

  145. Thanks in support of sharing such a pleasant thinking, post is good, thats why i have read it completely

  146. Thanks a lot for the article.Thanks Again. Will read on…

  147. Yes! Finally someone writes about 100 pure skin care.Here is my blog post NatureFused

  148. Great post. Really Cool.

  149. Hi there, just became alert to your blog through Google, and found that it’s truly informative. I?m gonna watch out for brussels. I will appreciate if you continue this in future. Many people will be benefited from your writing. Cheers!

  150. Can you please send me the code for this script or please tell me in detail about this script?

  151. I am really impressed with your writing skills as well as withthe layout on your blog. Is this a paid theme or didyou modify it yourself? Either way keep up the excellentquality writing, it’s rare to see a niceblog like this one nowadays.

  152. Awesome blog post.Thanks Again. Fantastic.

  153. Very good article post.Really thank you! Want more.

  154. Thanks so much for the article post.Thanks Again. Really Great.

  155. Thanks for the post.Thanks Again. Want more.

  156. Thanks for the blog article.Really looking forward to read more. Awesome.

  157. magnificent points altogether, you simply received abrand new reader. What could you recommend in regards to your submit that you simply madesome days in the past? Any sure?

  158. I wish I had a dime for every bad article I’ve read lately. I also wish other writers had your talent and style. Thank you.

  159. I loved your blog article.Really thank you! Cool.

  160. I appreciate you sharing this blog.Much thanks again. Really Great.

  161. stromectol ivermectin stromectol usa – stromectol

  162. Thanks a lot for the post.Really looking forward to read more. Much obliged.

  163. nice post and i see lot`s of good comments as well. great job.

  164. Wow, great blog. Keep writing.

  165. Major thankies for the post.Thanks Again. Cool.

  166. Thanks so much for the article post.Much thanks again. Really Great.

  167. Im grateful for the article post.Really looking forward to read more. Will read on…

  168. Really appreciate you sharing this post. Want more.

  169. Say, you got a nice article post.Really looking forward to read more. Awesome.

  170. I really like and appreciate your article post.Really looking forward to read more. Keep writing.

  171. Appreciate you sharing, great blog article.Thanks Again.

  172. I cannot thank you enough for the article post. Great.

  173. Fantastic post.Thanks Again. Really Cool.

  174. Thanks for the blog.Really looking forward to read more. Great.

  175. Major thanks for the blog post. Keep writing.

  176. I can relate as someone who works in the accounting department.

  177. WOW just what I was searching for. Came here by searching for takipçi satın al

  178. Very good info. Lucky me I discovered your blog by accident.I have book-marked it for later! 룰렛

  179. doctors prescribing hydroxychloroquine near me how to get hydroxychloroquine

  180. photo essayhow to cite an article in an essayessay writing

  181. Looking forward to reading more. Great blog article.Thanks Again. Will read on…

  182. I have read so many articles or reviews on the topic of the blogger lovers except this paragraph is genuinely a pleasant post, keep itup.

  183. Hey, thanks for the blog.Thanks Again. Really Cool.

  184. over the counter erectile dysfunction medication – strongedpl.com ed pills that work

  185. Hello! I just want to provide a significant thumbs up for the great information you have below on this article. I will be returning to your blog for even more soon.

  186. Thank you for your blog article.Thanks Again. Keep writing.

  187. parahh gua abis wd 5jt dapet jekpoty di *SLOOT K1NG 69*

  188. pills erectile dysfunction generic ed pills – ed treatment pills

  189. Hi, I do think this is a great blog. I stumbledupon it 😉 I may return once again since I book-marked it. Money and freedom is the best way to change, may you be rich and continue to guide other people.

  190. Thanks so much for the blog.Really thank you! Really Cool.

  191. A round of applause for your article post.Really thank you! Much obliged.

  192. Thank you for the good writeup. It in truth was a entertainment account it. Look advanced to far brought agreeable from you! However, how can we be in contact?

  193. Thank you ever so for you blog.Really looking forward to read more.

  194. 581654 657202The urge to gamble is so universal and its practice so pleasurable, that I assume it ought to be evil. – Heywood Broun 642976

  195. Really appreciate you sharing this blog article.Much thanks again. Fantastic.

  196. Hi there, I enjoy reading through your article post.I wanted to write a little comment to support you.click here 안전토토사이트

  197. Wow, great blog post. Great.

  198. What an incredible manner of considering points.

  199. I really like and appreciate your article post.Much thanks again. Keep writing.

  200. wow, awesome blog post. Really Great.

  201. Howdy! I’m at work surfing around your blog from my new iphone 3gs!Just wanted to say I love reading through your blog and look forward to all your posts!Carry on the fantastic work!Feel free to surf to my blog post; Muama Ryoko Reviews

  202. Im grateful for the article.Thanks Again. Really Great.

  203. Im grateful for the article.Really looking forward to read more. Great.

  204. Hi there friends, how is everything, and what you wish for to say regarding this piece of writing, in my view its genuinely amazing designed for me. Jo Ann Fee Berne

  205. A big thank you for your article post.Really thank you! Really Cool.

  206. A round of applause for your post. Fantastic.

  207. Really informative blog post.Really thank you! Really Great.

  208. I really enjoy the article post.Really looking forward to read more. Fantastic.

  209. Im grateful for the blog article.Much thanks again. Fantastic.

  210. I think this is a real great blog post.Much thanks again. Really Great.

  211. My family members always say that I am wasting my time here atnet, however I know I am getting experience daily by reading thes nice content.ps4 games allenferguson ps4 games

  212. Thanks for sharing, this is a fantastic blog.Really thank you! Cool.

  213. Thanks again for the article.Really thank you! Fantastic.

  214. modafinil and weight loss – modapls provigil settlement

  215. book new lpg connection online bharat gas Fichier Torrent rto licence exam book gujarati pdf

  216. It’s actually a great and useful piece of info. I’m happy that you simply shared this useful info with us. Please keep us informed like this. Thanks for sharing.

  217. Im obliged for the article post.Much thanks again. Really Cool.

  218. Very informative article.Much thanks again. Cool.

  219. I cannot thank you enough for the blog post.Really thank you! Cool.

  220. I am not sure the place you are getting your information, but great topic. I must spend some time studying more or figuring out more. Thank you for fantastic information I was in search of this information for my mission.

  221. Really informative article post.Really looking forward to read more. Cool.

  222. Hey! Do you use Twitter? I’d like to follow you if that would be okay. I’m definitely enjoying your blog and look forward to new posts.

  223. This is one awesome blog.Really looking forward to read more.

  224. Greetings! Pretty practical tips With this individual article! It is the little improvements that can make the best alterations. Several thanks for sharing!

  225. Usually I do not read article on blogs, but I wishto say that this write-up very pressured me to try and do so!Your writing style has been surprised me. Thanks, quite nicearticle.

  226. A big thank you for your blog article.Much thanks again. Great.

  227. So, it isn’t uѕable for prime quality auɗio.

  228. A round of applause for your article post.Really thank you! Will read on…

  229. Wow, great post.Much thanks again. Really Great.

  230. Hey, thanks for the article. Fantastic.

  231. ivermectin cream uk – stromectol ivermectin generic ivermectin for humans

  232. Major thanks for the article post. Awesome.

  233. I think this is a real great article post.Thanks Again. Will read on…

  234. Appreciate you sharing, great blog article.Much thanks again. Keep writing.

  235. I really liked your blog article.Really looking forward to read more. Really Great.

  236. Gclblq – tadacip india pharmacy Didlzl ykcsfk

  237. Hello, after reading this awesome paragraph i am too cheerful to share my familiarity here with mates.

  238. With havin so much content and articles do you ever run into

  239. where can you get prednisone – prednisplus.com mail order prednisone

  240. I need to to thank you for this fantastic read!! I absolutely enjoyed every little bit of it. I have you saved as a favorite to check out new stuff you postÖ

  241. Hey There. I found your blog using msn. This is a very well written article.I will make sure to bookmark it and come back to read more of youruseful information. Thanks for the post. I will definitely comeback.

  242. Pretty nice post. I just stumbled upon your blog and wanted to say that I’ve truly enjoyed browsing your blog posts. After all I?ll be subscribing to your feed and I hope you write again very soon!

  243. I loved your post.Really thank you! Want more.

  244. Tetracycline uspharmus.com online pharmacy busted

  245. phd dissertation dissertation proposal writing service dissertation abstracts

  246. Enjoyed every bit of your article.Thanks Again. Want more.

  247. Thanks again for the article. Awesome.

  248. Very informative post.Thanks Again. Want more.

  249. you’ve gotten an important blog right here! would you like to make some invite posts on my blog?

  250. I cannot thank you enough for the article.Thanks Again. Awesome.

  251. Really informative blog post. Much obliged.

  252. I truly appreciate this blog article.Really looking forward to read more. Awesome.

  253. Thank you for your blog article.Thanks Again. Keep writing.

  254. what is omeprazole used for can i take prilosec at night

  255. I cannot thank you enough for the article post.Much thanks again. Awesome.

  256. What a material of un-ambiguity and preserveness of precious know-how to eat out a woman on the topic of unpredicted emotions.

  257. Wow that was unusual. I just wrote an extremely long comment but after I clicked submitmy comment didn’t show up. Grrrr… well I’m not writingall that over again. Anyhow, just wanted to say wonderful blog!

  258. Really appreciate you sharing this article. Really Great.

  259. where can i order diclofenac sodium tablets

  260. I really enjoy the post.Much thanks again. Awesome.

  261. I truly appreciate this post.Thanks Again. Really Great.

  262. Enjoyed every bit of your article.Really looking forward to read more. Fantastic.

  263. I appreciate you sharing this post.Much thanks again. Want more.

  264. Great post.

  265. What’s up, yup this paragraph is in fact pleasant and I have learned lot of things from it on the topicof blogging. thanks.

  266. how much does cbd lower blood pressure in patients with hypertension

  267. Im thankful for the article.Much thanks again.

  268. Remarkable! Its really remarkable article, I have got much clear idearegarding from this article.

  269. I am so grateful for your post.Really thank you! Really Great.

  270. Im thankful for the article post. Much obliged.

  271. Thanks for finally talking about >COPA DA RÚSSIA – 2018: TRABALHANDO O PERTENCIMENTO CULTURAL ATRAVÉS DA SELEÇÃO BRASILEIRA – Redesenho Educacional

  272. Thanks so much for the article.Much thanks again. Really Cool.

  273. Thanks for sharing your thoughts on rent assistance austin. Regards

  274. Hi my loved one! I wish to say that this article is awesome, nice written and include approximately all important infos. I would like to peer extra posts like this .

  275. Really enjoyed your article. I’ll be back to read more sometime

  276. Good day! Do you use Twitter? I’d like to follow you if that wouldbe ok. I’m absolutely enjoying your blog and look forward to newposts.

  277. Im thankful for the article post.Thanks Again. Cool.

  278. Wow, great blog article. Cool.

  279. Wow, great post.Thanks Again. Much obliged.

  280. I really like and appreciate your article.

  281. An fascinating dialogue is value comment. I believe that it is best to write more on this matter, it might not be a taboo subject however usually individuals are not sufficient to speak on such topics. To the next. Cheers

  282. I appreciate you sharing this article.Really thank you! Want more.

  283. plaquenil pregnancy plaquenil for sale hcqs 200

  284. I think this is a real great blog article.Really thank you! Really Cool.

  285. I really enjoy the blog.Much thanks again. Great.

  286. Appreciate you sharing, great blog post.Thanks Again. Want more.

  287. Very informative blog article.

  288. Major thankies for the post.Really looking forward to read more. Fantastic.

  289. Thanks a lot for the article post.Much thanks again. Cool.

  290. My brother recommended I might like this blog. He was totally right. This put up actually made my day. You can not believe simply how so much time I had spent for this info! Thank you!

  291. I really liked your post.Really looking forward to read more. Fantastic.

  292. Very informative article post.Really looking forward to read more. Great.

  293. I really liked your content. Thank you for creating it. I’m a massive fan of your stuff.

  294. I cannot thank you enough for the article post.Really thank you! Much obliged.

  295. magnificent issues altogether, you simply won a new reader. What would you recommend in regards to your publish that you just made a few days ago? Any positive?

  296. I cannot thank you enough for the blog post.Really looking forward to read more. Fantastic.

  297. Thanks a lot for the blog.Thanks Again. Fantastic.

  298. Wow, great article.Really thank you! Keep writing.

  299. WOW just what I was searching for. Came hereby searching for your asmr

  300. Really appreciate you sharing this post.Really looking forward to read more. Cool.

  301. Major thankies for the blog article.Really thank you! Awesome.

  302. Looking forward to reading more. Great article.Much thanks again.

  303. norvasc dosage amlodipine benazepril amlodipine doses

  304. Knowing your routes like the back of your hand will make things go much more smooth in an actual game.

  305. משפחה שמחליטה להירגע קצת באורגיה סקסית בין כולםליווי במרכז

  306. Nvzcse – research paper on internet Wghttl qvbpzr

  307. Great post. I was checking constantly this blog and I am impressed! Very helpful info specially the last part 🙂 I care for such info much. I was looking for this particular info for a long time. Thank you and good luck.

  308. stromectol online – stromectol order online stromectol brand

  309. pills erectile dysfunction: erection pills – male ed pills

  310. Enjoyed every bit of your article post.Really looking forward to read more. Great.

  311. I appreciate you sharing this article post.Much thanks again. Fantastic.Loading…

  312. Do you have a spam problem on this blog; I also am a blogger, and Iwas curious about your situation; we have created some nice methods and we are lookingto trade solutions with others, be sure to shoot me an e-mail if interested.

  313. Hey, thanks for the article.Really thank you! Great.

  314. Hi there, yes this article is in fact nice and I have learned lot of things from it on the topic of blogging.thanks.

  315. That is a really good tip especially to those new to the blogosphere. Short but very accurate info… Thank you for sharing this one. A must read post!

  316. Hi there, I check your new stuff on a regular basis.Your story-telling style is awesome, keep up the good work!

  317. I loved your article post.Really looking forward to read more. Really Cool.

  318. You said that perfectly.how to become a good writer essay essay writing service custom thesis writing services

  319. So how do they stack up in terms of how well they work.

  320. I want to to thank you for this very good read!! I certainly loved every bit of it.I have you book marked to check out new things you post…

  321. This is one awesome article.Really thank you! Awesome.

  322. these things have different for more than twenty years, and in

  323. Im thankful for the blog.Thanks Again. Keep writing.

  324. I have read so many content about the blogger lovers but this paragraph
    is actually a good post, keep it up.

  325. Very neat article post.Really looking forward to read more. Cool.

  326. walgreens online pharmacy – canadian pharmacy world coupon code canadian pharmacy no rx

  327. There’s definately a great deal to know about this subject. I like all the points you have made.

  328. I’m not sure where you’re getting your info, but great topic.I needs to spend some time learning much more or understanding more.Thanks for wonderful information I was looking for this information for my mission.

  329. Measuring only 2″ across and 3/4″ tall, The Nano Droneis a fully functioning 6-Axis Gyro Enabled Quad-copter.

  330. Hey there! Do you use Twitter? I’d like to follow you if that would be ok.I’m absolutely enjoying your blog and look forward to new updates.

  331. Thanks , I’ve just been searching for info about this topic for a long time and yours is thegreatest I’ve found out till now. But, what about the bottom line?Are you sure concerning the source?

  332. I like the valuable information you provide in your articles.I will bookmark your blog and check again here regularly.I am quite sure I will learn plenty of newstuff right here! Best of luck for the next!

  333. Well I truly enjoyed studying it. This subject provided by you is very constructive for correct planning.

  334. Really enjoyed this blog article. Really Great.

  335. A round of applause for your blog post.Much thanks again. Keep writing.

  336. Great article.Thanks Again. Cool.

  337. Pretty nice post. I just stumbled upon your blog and wished to say that I have really loved browsing your blog posts. After all I will be subscribing to your feed and I’m hoping you write once more soon!

  338. Great, thanks for sharing this post. Great.

  339. Thanks again for the blog. Want more.

  340. Very good article.Really looking forward to read more. Awesome.

  341. Merci pour le test ! J’hésitais à le prendre, j’avais cru que c’était une sorte de Dead Age en plus complexe. Tu as sauvé ma précieuse monnaie.

  342. Really informative post.Thanks Again. Great.

  343. magnificent post, very informative. I wonder why the other experts of this sector don’t realize this. You must continue your writing. I am confident, you have a huge readers’ base already!

  344. I truly appreciate this post. I’ve been looking everywhere for this! Thank goodness I found it on Bing. You have made my day! Thx again

  345. My partner and I absolutely love your blog and find
    nearly all oof your post’s to be just what I’m looking for.
    Do you offer guest writers to write content to suit your needs?
    I wouldn’t mind producing a post or elaborating on a few of the subjects you write with regards to here.

    Again, awesome site!

    Here is my web site :: oferty pracy mielec ogłoszenia

  346. Jiangsu Kaimei Electronic Materials Co., Ltd.

  347. I loved your blog post. Much obliged.

  348. Im thankful for the article post.Much thanks again. Great.

  349. Fantastic blog post. Cool.

  350. Really appreciate you sharing this blog article.Really thank you! Much obliged.

  351. I cannot thank you enough for the article post.Really thank you! Will read on…

  352. Great, thanks for sharing this blog article.Really thank you! Great.

  353. I value the article post.Really thank you! Really Great.

  354. Very neat blog post.Much thanks again. Fantastic.

  355. Im thankful for the blog post.Thanks Again.

  356. Really informative article.Much thanks again. Fantastic.

  357. A big thank you for your article. Want more.

  358. Very good blog post.Really looking forward to read more. Want more.

  359. Hi there, I enjoy reading all of your post. I wanted to write a little comment
    to support you.

    Have a look at my web site; praca fizjoterapeuta szwajcaria (giphy.com)

  360. Kelvin Kaemingk has over two decades of helping people make smarter decisions regarding their mortgage and money decisions. He began his career in financial planning and migrated into the mortgage space in 2002. He is passionate and committed to helping people throughout their lives, make the best financial decisions for themselves and their families. As a father of three, and now Papa K (grandpa) to one, a team builder and recruiter, Kelvin thrives on helping others realize their potential, often referenced as “Everyone’s biggest fan”. Kelvin Kaemingk is the Area Manager for loanDepot and Co-Host of the Real Estate Chalk Talk radio program based in the Minneapolis – St. Paul area. Kelvin Kaemingk, NMLS 251124 | Branch NMLS 1139048

  361. I really liked your blog post.Really looking forward to read more. Will read on…

  362. I will right away clutch your rss as I can not to find your e-mail subscription hyperlink or e-newsletter service. Do you have any? Please let me know in order that I may subscribe. Thanks.

  363. Hey, thanks for the article post. Awesome.

  364. Everyone loves it whenever people get together and share views.Great blog, keep it up!

  365. Very good blog post.Really looking forward to read more. Cool.

  366. Thanks a lot for the article post.Really looking forward to read more. Much obliged.

  367. Very neat post.Much thanks again. Fantastic.

  368. Hello everyone Welcome back to our channel
    we are happy to see you on our channel where we delve into the world of luxury and the places of costly but
    favorable to see.
    thank you for watching last video
    We are going to talk about top 10 Luxurious Aquariums
    of the world
    Loyal Luxury is the real channel that can give you entertainment and real meaning of
    life.

    https://www.youtube.com/watch?v=YagpMbu0aDM&ab_channel=LoyalLuxury

  369. Thanks for sharing, this is a fantastic blog post. Awesome.

  370. Great article post.Much thanks again. Keep writing.

  371. Thanks a lot for the article. Really Cool.

  372. Thank you, I’ve recently been looking for info approximately this topic for ages and yours is the greatest I’ve came upon so far.But, what concerning the conclusion? Are you surein regards to the supply?

  373. stromectol usa ivermectin tablets – stromectol ivermectin tablets

  374. Awesome blog.Really looking forward to read more. Fantastic.

  375. Really informative post. Want more.

  376. hi!,I like your writing very a lot! proportion we keep up a correspondence extra approximately your post on AOL? I need an expert in this house to unravel my problem. May be that is you! Looking ahead to see you.

  377. Thank you for every other magnificent article. Where else may just anyone getthat type of information in such a perfect approach of writing?I’ve a presentation next week, and I’m at the search for such information.

  378. An intriguing discussion is definitely worth comment. I do think that you need to publish more on this subject, it might not be a taboo matter but typically people do not talk about such issues. To the next! Best wishes!!

  379. how much is lipitor discount atorvastatin – lipitor purchase online

  380. Crfwwv – write your own i have a dream speech Imxaff dtfjmj

  381. Thanks-a-mundo for the post. Fantastic.

  382. generic minocin generic panmycinsumycin tablets

  383. Wow! This could be one particular of the most helpful blogs We’ve ever arrive across on this subject. Actually Fantastic. I’m also an expert in this topic therefore I can understand your hard work.

  384. Fantastic blog article.Much thanks again. Want more.

  385. I really enjoy the blog post.Really looking forward to read more. Really Cool.

  386. Thank you ever so for you blog post.Thanks Again. Great.

  387. Really informative blog post.Thanks Again. Much obliged.

  388. Major thanks for the article. Keep writing.

  389. Fastidious answers in return of this query with solid arguments and describing everythingabout that.

  390. modafinil modafinil provigil modalert online

  391. Great post. I was checking continuously this blog and I’m impressed!Extremely helpful information specifically the last part 🙂 I care forsuch info much. I was seeking this particular info for a very long time.Thank you and good luck.

  392. No matter if some one searches for his essential thing, so he/she

  393. I really enjoy the blog post. Awesome.

  394. Wow, wonderful blog format! How long have you been running a blog for?
    you make blogging glance easy. Thhe overall look of your website is magnificent, as well as the content material!

    Also visit my websit annose (Abrek.org)

  395. Great, thanks for sharing this article. Keep writing.

  396. Thank you, I’ve recently been looking for info approximately this subject for a long time and yours is the greatest I have came upon so far.But, whhat in regards to
    the bottrom line? Are you certain concerning the supply?

    Feel free to visit my blog – anonse praca lublin dorywcza

  397. Wow, great blog article.Really thank you! Great.

  398. You are my inspiration, I own few blogs and often run out from post :). «To die for a religion is easier than to live it absolutely.» by Jorge Luis Borges.

  399. Automobili Srbije Cars are different and old. Any edda on the Internet on the area has the right. The set to rights to memoirs and comment. Today this life is connected with cars in Europe

  400. Im grateful for the blog article.

  401. Well I definitely liked reading it. This subject provided by you is very useful for proper planning.

  402. Terrific info, Regards. dissertation writers graduate school essay writing service

  403. These are truly great ideas in regarding blogging. You have touched some
    good points here. Any way keep up wrinting.

  404. ivermectin dose for cats ivermectin for rabbit fur mites

  405. Im obliged for the blog post.Much thanks again. Really Cool.

  406. Voznja motocikla je ples sa putem.
    Frame sliders provide added protection in case of a fall.
    Reference current events for timely and relevant comments. https://www.pinterest.com/pin/980940362573993937/

  407. Hey, thanks for the blog.Much thanks again. Great.

  408. What’s Taking place i’m new to this, I stumbled
    upon this I’ve discovered It positively useful and it has helped
    me out loads. I hope to give a contribution & assist other customers like its aided
    me. Good job.

  409. Thanks again for the blog post.Really looking forward to read more. Fantastic.

  410. Thanks , I’ve just been searching for information aboutthis topic for a long time and yours is the greatest I’ve discovered till now.However, what in regards to the conclusion? Areyou certain in regards to the supply?

  411. I loved your article.Thanks Again. Want more.

  412. Thanks in favor of sharing such a good opinion, piece of writing is nice, thats whyi have read it completely

  413. Great, thanks for sharing this blog article.Much thanks again. Awesome.

  414. אורגיה במצלמת רשת של 2 גברים ו3 בנות שעושים כל מה שמבקשים מהםנערות ליווי בתל אביב

  415. I appreciate you sharing this blog.Really looking forward to read more. Great.

  416. Thank you for helping out, fantastic information. Considering how dangerous everything is, nothing is really very frightening. by Gertrude Stein.

  417. Im grateful for the post.Much thanks again. Will read on…

  418. An intriguing discussion is worth comment. I do believe that you should write more on this subject matter, it may not be a taboo subject but usually folks don’t talk about these issues. To the next! Many thanks!!

  419. Your way of addressin this subject is both fantastic as well as motivating.

  420. Really enjoyed this blog article.Really looking forward to read more. Keep writing.

  421. I have read so many articles concerning the blogger lovers except this articleis truly a nice post, keep it up.

  422. I’m not sure where you’re getting your info, but good topic.I needs to spend some time learning more or understanding more.Thanks for excellent information I was looking for this info for my mission.

  423. Very neat article.

  424. Amazing issues here. I’m very satisfied to peer your article. Thanks so much and I am taking a look forward to touch you. Will you please drop me a e-mail?

  425. Thanks-a-mundo for the blog. Will read on…

  426. Thank you ever so for you post.Really looking forward to read more. Fantastic.

  427. The “selfie” phenomenon gained popularity with the rise of front-facing cameras. Phone repair shops often carry a variety of replacement parts for different phone models. Incorporate relevant emojis to convey emotions uniquely.
    https://twitter.com/A1Expert2023/status/1721862938028376303

  428. Hello colleagues, its enormous article regarding teachingand fully defined,keep it up all the time.

  429. I really liked your article.Really looking forward to read more. Want more.

  430. lasix generic generic lasix – lasix medication

  431. 🔹เว็บตรง มั่นคง ปลอดภัe🔹⚡️ฝาก/ถอน ไม่มีขั้นต่ำ ระบบอัตโนมัติ⚡️เว็บตรงไม่ผ่านเอเย่นต์ ตัดปัญหาโดนโกง⚡️คืนยอดเสีย 5📍ครบจบในเว็บเดียว บริการตลอด 24 ช.ม♣️คาสิโน ⚽️บoล 🥊มวe 🎱หวe 🎰สล๊อต

  432. Great blog.Much thanks again. Cool.

  433. Unique comments encourage others to express their views.
    Dom je ostrvo gde se mozete sakriti od zivotnih oluja.
    Современные тенденции в дизайне мебели делают дом еще более инновационным и удобным.
    https://twitter.com/svadba10x15ru/status/1753742371743830488

  434. I really enjoy the blog post.Thanks Again. Much obliged.

  435. Muchos Gracias for your blog article. Great.

  436. I value the post.Really thank you! Great.

  437. Prodati https://www.facebook.com/a1expert2013/posts/pfbid0Vr5AHfL7JYHQPWPG7azQUvtn3T5xVYDcDE5GeT52aZYErwyPU9Ggk9QDbCcK4scFl Srpska kultura uključuje elemente turskog i austrougarskog uticaja.

  438. I have been exploring for a bit for any high-quality articles or blog posts
    on this kind off house . Exploring in Yahoo I finally
    stumbled upon this site. Studying this information So i’m glad to show that I have a
    very gooid uncanny feeling I discovered exactly what I needed.

    I such a lott for sure wilol makoe certain to do not omit this
    site and provides it a look regularly.

    My blog post … mieszkania na sprzedaż starachowice

  439. identifies a home defeat to Nottingham Forest. browse this

  440. I value the blog article.Thanks Again. Cool.

  441. Enjoyed every bit of your article.Really thank you! Want more.

  442. Great article.Much thanks again. Keep writing.

  443. I’m not sure exactly why but this blog is loading veryslow for me. Is anyone else having this issue or is it a problem on my end?I’ll check back later and see if the problem still exists.

  444. A round of applause for your article post.Really looking forward to read more. Want more.

  445. Very good info. Lucky me I found your blog by chance (stumbleupon). I have saved as a favorite for later!

  446. This is a very good tip especially to those new to the blogosphere. Brief but very accurate informationÖ Thank you for sharing this one. A must read article!

  447. Hey there just wanted to give you a brief heads up and let you know a few of the images aren’t loading correctly. I’m not sure why but I think its a linking issue. I’ve tried it in two different internet browsers and both show the same outcome.

  448. Great article! This something that I always want to see.

  449. It as difficult to find well-informed people on this subject, but you sound like you know what you are talking about! Thanks

  450. Transmisión en vivo de habs vs thunderstorm: cómo ver la copa morgan de la NHL 2021 por última vez en internet

  451. สาวกผี สาวกหงส์ สาวกสิงห์ สาวกเรือ สาวกไก่ สาวกหมาจิ้งจอก ไม่ว่าคุณจะเป็นสาวกไหนก็ตาม UFABET ขอเป็นส่วนหนึ่งส่วนใดสำหรับการเปลี่ยนแปลงสิ่งที่คุณถูกอกถูกใจเป็นรายได้ ด้วยการยกคาสิโนมาไว้ให้คุณพนันบอลออนไลน์ได้อย่างง่ายดายกันเลยขอรับ

  452. Great post! I truly appreciate this post. Some nice points there. Thanks for writing this.

  453. Hi, I log on to your blog daily. Your humoristic style is witty,keep doing what you’re doing!

  454. This is one awesome blog post.Thanks Again.

  455. Awsome post and straight to the point. I don’t know if this is in fact the best place to ask but do you people have any thoughts on where to get some professional writers? Thanks 🙂

  456. I’m extremely impressed with your writing skills and also with the layout on your blog. Is this a paid theme or did you customize it yourself? Either way keep up the excellent quality writing, it is rare to see a great blog like this one nowadays..

  457. Greetings! Very helpful advice within this post! It’s the little changes that will make the greatest changes. Thanks for sharing!

  458. An intriguing discussion is worth comment. I do believe that you need to publish more on this subject matter, it might not be a taboo matter but generally people do not talk about such issues. To the next! Best wishes!!

  459. I truly appreciate this post. I ave been looking everywhere for this! Thank goodness I found it on Bing. You have made my day! Thank you again..

  460. Hmm is anyone else encountering problems withthe images on this blog loading? I’m trying to figureout if its a problem on my end or if it’s the blog. Any suggestionswould be greatly appreciated.

  461. We stumbled over here different website and thougght I may as well check
    things out. I like what I see so now i am following you.
    Look forward to looking at your web pasge for a secon time.

    Visit my web site: oferty pracy w anglii od zaraz 2022

  462. Itís difficult to find well-informed people in this particular topic, however, you sound like you know what youíre talking about! Thanks

  463. fantastic issues altogether, you simply gained a emblem new reader.What could you recommend in regards to your submit that you simply made a fewdays in the past? Any certain?

  464. Thanks for ones marvelous posting! I quite enjoyed reading it, you could be a great author.I will make sure to bookmark your blog and definitely will come back atsome point. I want to encourage that you continue yourgreat work, have a nice weekend!

  465. I value the post.Really thank you! Will read on…

  466. #Oglasi Jeftino https://www.pinterest.com/pin/1095852521818595841/
    Keramika i sanitarije učiniće vaše kupatilo mestom luksuza i udobnosti. Antikviteti nas povezuju sa prošlošću. Srbija nudi razne muzičke festivale, uključujući EKSIT i Gitarski festival.

  467. Thank you for your post.Thanks Again.

  468. escitalopram time of day to take how to lose weight on lexapro

  469. Bardzo interesujące informacje! Idealnie to, czego szukałem! koncentrator tlenu domowy.

  470. Thank you ever so for you blog article.Thanks Again. Much obliged.

  471. how to get valtrex in mexico valtrex order uked problems treatment

  472. Great post. I will be experiencing many of these issuesas well..

  473. You need to also be positioned inside the state where you are placing the bet.

  474. I will immediately take hold of your rss feed as I can’t find your e-mail subscription link or newsletter service. Do you have any? Please permit me understand so that I could subscribe. Thanks.

  475. Article writing is also a fun, if you know after that you can write otherwise it is complex to write.

  476. Your mode of describing all in this piece of writing is actuallygood, every one can easily understand it, Thanksa lot.

  477. fantastic points altogether, you simply receiveda new reader. What would you recommend in regardsto your put up that you just made some days in the past?Any certain?Have a look at my blog; healthy weight

  478. Serious 、workable、ordinary may possibly be the design rolex replica structure.

  479. Great story it is surely. I have been awaiting for this update.

  480. Thanks a lot for the post.

  481. I’ll right away grab your rss feed as I can not find youremail subscription link or e-newsletter service.Do you have any? Please let me know in order that I may subscribe.Thanks.

  482. Greetings! Very useful advice within this article! It’s the little changes which will make the most significant changes. Thanks for sharing!

  483. I am not sure where you are getting your information, but good topic. I needs to spend some time learning much more or understanding more. Thanks for wonderful information I was looking for this information for my mission.

  484. Right away I am going to do my breakfast, later than having my breakfastcoming over again to read more news.

  485. tom selleck and ed pills – best pill on the market for ed purchase pills to fix ed

  486. Hi there, I check your new stuff on a regular basis

  487. I really enjoy the blog article.Really thank you!

  488. My relatives all the time say that I am killing mytime here at net, however I know I am getting familiarity all thetime by reading such good articles or reviews.Feel free to visit my blog; healthy eating for kids

  489. Hi there! Do you know if they make any plugins to help with SEO?I’m trying to get my blog to rank for some targetedkeywords but I’m not seeing very good results.If you know of any please share. Thanks!

  490. Can someone recommend Large Butt Plugs? Cheers xox

  491. Info well considered.! interactions for modafinil

  492. I truly appreciate this article.Really thank you! Will read on…

  493. Awesome post.Thanks Again. Cool.

  494. I was able to find good information from your content. Maurise Noble Hans

  495. Very descriptive post, I enjoyed that bit. Will therebe a part 2?

  496. express rx pharmacy services vicodin canada pharmacy

  497. I value the blog post.Really thank you! Fantastic.

  498. F*ckin’ tremendous things here. I am very glad to see your article. Thanks a lot and i am looking forward to contact you. Will you please drop me a mail?

  499. Hello, I log on to your blogs daily. Your humoristic style is witty, keep up thegood work!

  500. Hi there i am kavin, its my first occasion to commenting anywhere,when i read this paragraph i thought i could also makecomment due to this brilliant paragraph.

  501. An intriguing discussion is worth comment. I believe thatyou should write more on this topic, it may not be ataboo matter but generally people don’t talk aboutthese topics. To the next! Kind regards!!

  502. Remarkable issues here. I’m very happy to look your article.Thank you so much and I’m having a look ahead to contact you.Will you please drop me a mail?

  503. patellofemoral arthritis ivermectin for humans amazon side effects for ivermectin

  504. I appreciate you sharing this blog article.Much thanks again. Much obliged.

  505. What’s up, after reading this remarkable paragraph i am as wellcheerful to share my familiarity here with colleagues.

  506. Currently it appears like Drupal is the top blogging platform available right now.(from what I’ve read) Is that what you are using on your blog?

  507. How short this meeting was, he thought. Hugging Arya, he mumbled, “Then you have to stay here.” “What if I don’t want to…” Arya teased.

  508. My family members always say that I am wasting my time here at net, but I know I am getting familiarity all the time by reading thes pleasant posts.

  509. Enjoyed every bit of your blog article.Much thanks again. Really Great.

  510. Really informative article post.Thanks Again. Great.

  511. afyon hava durumu; afyon için hava durumu en güncel saatlik, günlük ve aylık tahminler.

  512. amlodipine side effect what is norvasc] amlodipine side effect

  513. Some really quality content on this internet site, saved to my bookmarks.

  514. It’s actually a cool and helpful piece of information. I am gladthat you shared this useful info with us. Please keep us up to date likethis. Thanks for sharing.

  515. You can elevate your question within the remark field given under.

  516. Very informative article.Much thanks again. Really Great.

  517. I used to be suggested this blog by means of my cousin. I’m now not positive whether this publish is written by means of him as nobody else understand such distinctive about my problem. You’re amazing! Thank you!

  518. Thanks a lot for the blog article. Fantastic.

  519. Thank you for your article post.Much thanks again. Awesome.

  520. What’s Taking place i am new to this, I stumbled upon this I have discovered It positively helpful and it has helped me out loads. I’m hoping to contribute & aid different users like its helped me. Good job.

  521. Have you ever heard of second life (sl for short). It is essentially a online game where you can do anything you want. SL is literally my second life (pun intended lol). If you want to see more you can see these sl articles and blogs

  522. That is a great tip particularly to those fresh to the blogosphere. Brief but very accurate informationÖ Appreciate your sharing this one. A must read post!

  523. However, last summer, Barcelona had to face serious financial problems and unable to renew the contract with the News. Until finally referred to move out to play for Paris Saint-Germain. in the land of Paris SG perfume

  524. Livestock for sale[…]Wonderful story, reckoned we could combine some unrelated data, nevertheless really worth taking a appear, whoa did one learn about Mid East has got more problerms too […]

  525. Thanks-a-mundo for the blog article.Much thanks again. Much obliged.

  526. what is an ed pill – jacked up ed pills bravado ed pills

  527. roxithromycin online minocin tabletsorder clindamycin

  528. Generally I do not post on blogs, but I would like to say that this post really forced me to do so! really nice post

  529. Ꮲretty great post. I simply stumbⅼed uρon your Ьlog and wanted tօ say that I’ve truly enjoyed surfing around your blog posts.In any case I will Ƅe subsϲribing for your feed and I hope you write again soon!

  530. A big thank you for your post.Really looking forward to read more. Great.

  531. Piece of writing writing is also a excitement, if you be acquainted with afterward you can write if not it is difficult to write.

  532. #Oglasi Bui https://www.pinterest.com/oglasisrb/
    Usluge izgradnje obuhvataju sve faze od projektovanja do puštanja objekta u rad. Kolekcionarstvo nas podstiče da tražimo lepotu i umeće u svakodnevnim predmetima. Srpski jezik spada u slovensku grupu jezika.

  533. doctors for hydroxychloroquine plaquenil pill

  534. An interesting discussion is definitely worth comment.I do think that you need to write more about this subject matter, it might not bea taboo subject but usually folks don’t discuss these topics.To the next! Cheers!!

  535. Thanks a lot. Ample forum posts. canada pharmacy online

  536. Thanks for sharing, this is a fantastic article.Really thank you! Keep writing.

  537. Major thanks for the post.Really looking forward to read more. Really Great.

  538. ed vacuum pump trusted india online pharmacies – mens erections

  539. I read this article completely concerning the difference of most recent and previous technologies, it’s remarkable article.

  540. I am not sure where you are getting your info, butgreat topic. I needs to spend some time learning much more or understanding more.Thanks for fantastic information I was looking for this info formy mission.

  541. Wow, great article.Really looking forward to read more. Much obliged.

  542. Thanks again for the blog article.Much thanks again. Really Cool.

  543. paper writer – college paper help thesis writing services

  544. I wanted to thank you for this great read!! I certainly enjoyed every bit of it. I have you book-marked to check out new stuff you postÖ

  545. Thanks again for the post.Thanks Again. Awesome.

  546. Hi! I just wanted to ask if you ever have any issues with hackers?My last blog (wordpress) was hacked and I ended up losing months of hard work due to no back up.Do you have any methods to prevent hackers?

  547. stromectol canada п»їivermectin on line sales

  548. This piece of writing is actually a nice one it assists new net visitors, who are wishing in favor of blogging.

  549. Howdy are using WordPress for your blog platform? I’m new to the blog world but I’m trying to get started and create my own. Do you need any html coding expertise to make your own blog? Any help would be really appreciated!

  550. I really like looking through a post that will make people think. Also, many thanks for permitting me to comment!

  551. Awesome blog, I’m going to spend more time researching this topicslot gacor

  552. But I assume that only a joke. After Aunt Ninik left for work, I was alone in this lonely house.

  553. Itís nearly impossible to find well-informed people about this topic, however, you sound like you know what youíre talking about! Thanks

  554. Actually when someone doesn’t know then its up to otherusers that they will assist, so here it happens.

  555. Hi, Neat post. There is a problem with your website in internet explorer, would test this… IE still is the market leader and a good portion of people will miss your wonderful writing because of this problem.

  556. I love reading an article that can make men and women think. Also, thank you for permitting me to comment.

  557. It챠s hard to come by educated people on this subject, however, you seem like you know what you챠re talking about! Thanks

  558. Very good blog post.Much thanks again. Cool.

  559. BEO285 เบททุนน้อยแตกหนัก เล่นก่อน รวยก่อนนาทีนี้ นาทีทอง รับโบนัส กระจาย!!! 💥ฝากครั้งแรก 300 รับฟรี 100 ทันที📲ฝาก-ถอน ไม่มีขั้นต่ำ 😘แอดมินน่ารักบริการดี 24 ชม. 💕”สมัครฟรี คลิ๊ก”….

  560. As a Newbie, I am constantly browsing online for articles that can benewfit me.Thank you

  561. Some truly interesting points you have written.Aided me a lot, just what I was searching for : D.

  562. I need to to thank you for this excellent read!! I definitely loved every bit of it. I’ve got you saved as a favorite to look at new stuff you post…

  563. health insurance plans south carolinaivermectin for humans

  564. Major thankies for the article.Much thanks again. Fantastic.

  565. Greetings! Very helpful advice in this particular post! It is the little changes that will make the most important changes. Many thanks for sharing!

  566. I am so grateful for your article post.Really looking forward to read more. Keep writing.

  567. I’ll right away grab your rss as I can not find your e-mail subscription link or e-newsletter service. Do you have any? Please let me know so that I could subscribe. Thanks.

  568. D’autres questions pourront venir s’ajouter lors de la lecture Akashique, vous pourrez également modifier vosquestions durant notre entretien en fonction de ce qui vous a été dit.

  569. I really liked your post.Really looking forward to read more.

  570. Hi, I log on to your new stuff like every week. Your humoristic styleis witty, keep up the good work!

  571. great points altogether, you simply won a new reader. What would you recommend in regards to your put up that you just made a few days ago? Any certain?

  572. Hi there! I just wanted to ask if you ever have any trouble with hackers? My last blog (wordpress) was hacked and I ended up losing a few months of hard work due to no data backup. Do you have any solutions to stop hackers?

  573. Good day! I simply would like to give you a big thumbs up for your great info you have got here on this post. I’ll be coming back to your blog for more soon.

  574. When I originally commented I clicked the “Notify me when new comments are added”checkbox and now each time a comment is added I get three e-mails with the same comment.Is there any way you can remove me from that service?Appreciate it!

  575. Hello, just wanted to say, I enjoyed thisarticle. It was practical. Keep on posting!

  576. I truly appreciate this blog post. Really Cool.

  577. WONDERFUL Post.thanks for share..extra wait .. …

  578. Excellent post. I was checking continuously this blog and I am impressed! Very useful info specifically the remaining section 🙂 I deal with such information a lot. I was looking for this particular info for a very lengthy time. Thanks and good luck.

  579. Too many bloggers nowadays yet only a few have posts worth spending time on reviewing.

  580. Your way of explaining the whole thing in this paragraph is actually pleasant, all be ableto without difficulty understand it, Thanks a lot.

  581. Does anyone know if I can purchase JUSTKRATOM Trainwreck Kratom Powder (justkratomstore.com) from Potosi Vapor, 301 E Jefferson St Suite 1, Potosi, MO, 63664?

  582. Hi there, You have done an excellent job. I will definitely digg it and personally suggest to my friends. I am confident they’ll be benefited from this website.

  583. Hey, thanks for the blog article. Fantastic.

  584. Im obliged for the article.Really thank you! Really Great.

  585. Thank you for your blog article. Fantastic.

  586. Thanks for the blog post. Want more.

  587. Wkfgja – how long do sildenafil pills last Vclaje klivfl

  588. Thanks for the update, how can I make is so that I get an alert email whenever you publish a fresh update?

  589. I loved your post.Really thank you! Keep writing.

  590. Howdy very cool site!! Guy .. Excellent .. Amazing .. I will bookmark your site and take the feeds additionally…I am happy to search out numerous helpful info here within the post, we need work out more strategies on this regard, thanks for sharing. . . . . .

  591. YourDoll JP 男性のためのかわいい美しい女性のシリコーンのダッチワイフ短い野外ツアーのための男性のための実用的な愛の人形

  592. hydroxychloroquine prophylaxis chloroquine stock

  593. Outstanding post however I was wanting to know if you couldwrite a litte more on this topic? I’d bevery grateful if you could elaborate a little bit further.Thanks!

  594. Thanks in support of sharing such a pleasant thought, paragraph is nice, thats why i have read it completely

  595. fenbendazole and ivermectin combination ivermectin for horses tractor supply

  596. Hello there! Would you mind if I share your blog with my myspace group? There’s a lot of folks that I think would really enjoy your content. Please let me know. Many thanks

  597. Really appreciate you sharing this blog. Great.

  598. Major thanks for the article.Really looking forward to read more.

  599. Aw, this was a really good post. Taking a few minutes and actual effort to make a good articleÖ but what can I sayÖ I procrastinate a lot and never manage to get anything done.

  600. Im thankful for the post.Really thank you!

  601. Мило ми е да те видам! https://www.facebook.com/people/Oglasi-Life/61557177542044/
    The ability to add advertisements to popular online magazines and portals increases their visibility.

  602. Hey there I am so grateful I found your site, I really found you by accident, while I was searching on Askjeeve for something else, Nonetheless I am here now and would just like to say thanks for a fantastic post and a all round thrilling blog (I also love the theme/design), I don’t have time to go through it all at the moment but I have book-marked it and also added in your RSS feeds, so when I have time I will be back to read more, Please do keep up the fantastic work.

  603. Excellent blog you’ve got here.. It?s difficult to find quality writing likeyours these days. I really appreciate people like you!Take care!!Feel free to surf to my blog post – internet marketing

  604. Really informative blog.Really thank you! Keep writing.

  605. What’s Happening i am new to this, I stumbled upon this I have discovered It absolutely helpful and it has aided me out loads. I’m hoping to give a contribution & help other customers like its aided me. Good job.

  606. Major thankies for the blog article.Really looking forward to read more. Want more.

  607. Awesome blog article.Really thank you! Will read on…

  608. Great, thanks for sharing this blog article.Much thanks again. Awesome.

  609. Great blog article.Really looking forward to read more. Cool.

  610. Very informative blog.Really looking forward to read more. Great.

  611. Major thanks for the blog post.Really thank you! Great.

  612. Thanks so much for the blog article. Will read on…

  613. Really appreciate you sharing this article.Much thanks again. Will read on…

  614. I think this is a real great post.Much thanks again. Want more.

  615. Very good blog post.Really looking forward to read more. Awesome.

  616. Say, you got a nice blog post.Really looking forward to read more. Much obliged.

  617. Major thanks for the post.Much thanks again. Awesome.

  618. Very good blog.Much thanks again. Will read on…

  619. I need to to thank you for this very good read!! I definitely enjoyed every little bit of it. I have you saved as a favorite to check out new stuff you post…

  620. Thanks in support of sharing such a nice thinking, paragraph is good, thats why i have read it entirely

  621. I enjoy looking through a post that will make men and women think.Also, thank you for allowing for me to comment!

  622. I have fun with, lead to I discovered exactly what I used to be looking for. You have ended my 4 day long hunt! God Bless you man. Have a nice day. Bye

  623. A motivating discussion is worth comment. I think that you should publish more on this subject matter, it may not be a taboo matter but generally people do not discuss these issues. To the next! All the best!

  624. pharmacy erectile dysfunction treatment canada rx pharmacy

  625. A motivating discussion is definitely worth comment. I do believe that you need to write more on this subject matter, it might not be a taboo subject but generally folks don’t talk about such subjects. To the next! Kind regards!!

  626. Remove card how to play blackjack online for money And it was all about the shoe leather – we walked to the most exclusive hotels and restaurants in central London, getting them to taste our tonic water against the competition.”

  627. I really enjoy the post. Fantastic.

  628. What’s up, everything is going perfectly here and ofcourse every one issharing facts, that’s in fact good, keep up writing.

  629. Enjoyed every bit of your post.Really thank you! Will read on…

  630. Excellent post however I was wanting to know if you could write a litte more on this topic? I’d be very grateful if you could elaborate a little bit more. Kudos!

    • Analitik p
    • 2024.03.22

    The significance of the moment is understood only in the future, when we look at it again.
    https://analitik3000.blogspot.com/
    Korisnici mogu da koriste sistem poklona i popusta da stimulisu aktivnost na platformi.

  632. Really informative post.Really thank you! Cool.

  633. Everyone loves what you guys are usually up too. This sort of clever work and coverage!Keep up the wonderful works guys I’ve included you guys to our blogroll.

  634. stromectol for humans ivermectin for humans – purchase oral ivermectin

  635. slots free slots for real money play slots online

  636. Thanks for writing this excellent article. I will return to read more.

  637. I needed to thank you for this excellent read!! I certainly loved every little bit of it. I’ve got you book marked to check out new things you post…

  638. I need to to thank you for this very good read!! I definitely loved every little bit of it. I’ve got you saved as a favorite to look at new stuff you post?

  639. Hey, thanks for the blog article.Really looking forward to read more. Fantastic.

  640. Thẳng đá Bóng Thời Điểm Hôm Nay, Link Coi Bóng Đá Trực Tuyến 24h kqbd7mĐội tuyển nước ta chỉ cần thiết một kết quả hòa có bàn thắng để lần loại hai góp mặt trên World Cup futsal. Nhưng, để làm được như vậy

  641. The next time I read a blog, I hope that it doesnt disappoint me as much as this one. I mean, I know it was my choice to read, but I actually thought youd have something interesting to say. All I hear is a bunch of whining about something that you could fix if you werent too busy looking for attention.

  642. It may seem like an easy shot, but it may be a bit easier for a teammate to make the shot.

  643. i need someone to write my research paper help me write my research paper help on writing a research paper

  644. When I originally commented I clicked the “Notify me when new comments are added”checkbox and now each time a comment is added I get three e-mailswith the same comment. Is there any way you can remove people from that service?Cheers!

  645. Aw, this was an incredibly good post. Finding the time and actualeffort to make a superb article… but what can I say… I put things off a wholelot and don’t seem to get anything done.

  646. I blog often and I really appreciate your information.Your article has really peaked my interest. I will bookmark your blog and keep checking for new information about once a week.I subscribed to your RSS feed too.

  647. I needed to thank you for this very good read!! I absolutely enjoyed every little bit of it. I have got you bookmarked to check out new stuff you postÖ

  648. Hi, yes this post is truly good and I have learned lot of things from it about blogging. thanks.

  649. Aw, this was an incredibly nice post. Spending some time and actual effort to make a good article… but what can I say… I put things off a whole lot and don’t seem to get nearly anything done.

  650. is probably the most important PSN code. Obviously, if you get

  651. the people’s pharmacy india pharmacy dysfunction

  652. Amazing! Its actually amazing post, I have got much clear idea on the topic of from this piece ofwriting.

  653. Everyone loves what you guys tend to be up too. This kind of clever work and exposure! Keep up the very good works guys I’ve added you guys to my own blogroll.

  654. It¦s actually a great and useful piece of information. I¦m glad that you simply shared this useful information with us. Please stay us informed like this. Thank you for sharing.

  655. Thanks for the auspicious writeup. It in reality used to be a amusement account it. Look advanced to more delivered agreeable from you! By the way, how can we keep up a correspondence?

  656. Nicely put, Thanks.how to write a synthesis essay dissertation assistance writing essay service

  657. Very efficiently written story. It will be helpful to anyone who utilizes it, as well as myself. Keep doing what you are doing – can’r wait to read more posts.

  658. tadalafil for sale online does tadalafil work

  659. monogatari series book tsukimonogatari Un Jeu Et Le Mettre Sur Microsoft Store Gratuitement ett livs historia book

  660. Heya i am for the primary time here. I came across this board and I find It really helpful & ithelped me out much. I am hoping to give one thing again and help others like you aided me.

  661. Hello, of course this paragraph is in fact good and I have learned lot of things from it concerning blogging. thanks.

  662. What a information of un-ambiguity and preserveness ofvaluable knowledge on the topic of unexpectedfeelings.Here is my blog post – Keto Premium Shot Reviews

  663. That is a great tip particularly to those new to the blogosphere. Brief but very precise information… Many thanks for sharing this one. A must read article!

  664. verapamil cordarone med amiodarone pacerone

  665. Las 7 mejores opciones de formas de youtube en 2021 Best have Free

  666. Has anyone ever been to Vape Affliction Vapor Store located in 1020 W Maloney Ave Suite B?

  667. Great blog you’ve got here.. Itís hard to find quality writing like yours nowadays. I seriously appreciate people like you! Take care!!

  668. Hey! I know this is kind of off topic but I was wondering if you knew where I could find acaptcha plugin for my comment form? I’m using the same blogplatform as yours and I’m having problems finding one?Thanks a lot!

  669. I could not refrain from commenting. Exceptionallywell written!my blog post: Vital Max XL

  670. What’s up friends, its great piece of writing about cultureand entirely
    defined, keep it up all thee time.

    Look att my web blog – praca bochum pakowanie kawy

  671. Hi, I do think this is a great blog. I stumbledupon it 😉 I
    may revisit once again sionce i have book-marked it. Money and freedom is the best wway to change, may you be rich and continue too help other people.

    Here is mmy web page – Praca W Niemczech Dla Kogiet (http://Www.Evernote.Com)

  672. Someone necessarily lend a haqnd to mae severely articles I
    would state. That is the very first time I frequented your website page and thus far?

    I amazed with thhe research you made to make this particular submit incredible.
    Great task!

    My web-site – dam pracę w norwegii (https://medium.com/@sebastian7/kiedy-jak-i-dlaczego-warto-przesadza%C4%87-kwiaty-doniczkowe-6c558bd4d4f5)

  673. I’m curious to find out what blog platform you happen to be utilizing? I’m having some small security problems with my latest site and I’d like to find something more safe. Do you have any suggestions?

  674. You have brought up a very superb details, thankyou for the post.

  675. Hello there! I could have sworn Iíve been to your blog before but after looking at some of the posts I realized itís new to me. Nonetheless, Iím definitely pleased I found it and Iíll be book-marking it and checking back frequently!

  676. free online slots online slot games slot games

  677. We will any lengthy time watcher and i also only believed Would head to plus claim hello right now there for ones extremely first time period.

  678. You are my inspiration, I own few blogs and sometimes run out from post :). “No opera plot can be sensible, for people do not sing when they are feeling sensible.” by W. H. Auden.

  679. Thank you for sharing your info. I really appreciate your efforts andI will be waiting for your next post thank you once again.

  680. apartments in staunton va the grayson apartments solaris apartments

  681. Have you ever heard of second life (sl for short). It is basically a game where you can do anything you want. Second life is literally my second life (pun intended lol). If you want to see more you can see these Second Life authors and blogs

  682. penicillin vs amoxicillin amoxicillin sale why does amoxil make my mouth hurt amoxicillin 500 dosage

  683. Im grateful for the blog article.Really looking forward to read more. Really Great.

  684. When I initially commented I clicked the “Notify me when new comments are added”checkbox and now each time a comment is added I get three emails with thesame comment. Is there any way you can remove me from that service?Thank you!

  685. to play alone rather than sharing and we have sold of given quite canada clenbuterol

  686. tamarack apartments apartments in bossier apartments in keller tx

  687. WONDERFUL Post.thanks for share..more wait .. 😉 ?Loading…

  688. You made your position very well!!writing 5 paragraph essay custom essay meister case study writing services

  689. Я оцениваю объективность и непредвзятость автора в представлении информации.

  690. canadian pharmacy meds reviews what time does cvs pharmacy inside target store open today?

  691. how to use ivermectin pour-on for cattle what does ivermectin treat in dogs

  692. I am now not sure the place you’re getting your information, however good topic. I needs to spend a while finding out more or working out more. Thank you for great info I used to be in search of this information for my mission.

  693. Restbet giriş ve giriş işlemleri için Restbet’e güncel giriş adresi üzerinden erişim sağladığınızdan emin olmanız güvenliğiniz açısından önemlidir.

  694. Hi there, just became alert to your blog through Google, and found that it is really informative.I’m gonna watch out for brussels. I will be grateful if you continue this in future.A lot of people will be benefited from your writing.Cheers!

  695. It’s the best time to make some plans for the longer term and it is time to be happy. I’ve read this put up and if I may I want to counsel you few fascinating issues or suggestions. Perhaps you can write next articles regarding this article. I wish to read even more issues approximately it!

  696. stromectol oral ivermectin tablets for humans for sale – ivermectin generic name

  697. They are certified arborists and employees are insured.

  698. medications for ed ed pills from canada – reasons for ed

  699. I have no idea why I read so many blogs, but I’m glad I do so. I always come out learning at least one thing every day.

  700. Hello mates, nice piece of writing and fastidious urging commented atthis place, I am truly enjoying by these. Minecraft free to play 2018

  701. I am so grateful for your blog.Thanks Again. Really Great.

  702. Thanx for the effort, keep up the good work Great work, I am going to start a small Blog Engine course work using your site I hope you enjoy blogging with the popular BlogEngine.net.Thethoughts you express are really awesome. Hope you will right some more posts.

  703. I’m curious to find out what blog platform you’re working with? I’m having some minor security issues with my latest website and I’d like to find something more safeguarded. Do you have any recommendations?

  704. WOW just what I was looking for. Came here by searching for akari rechargeable lamp

  705. I quite like reading a post that will make men and women think.Also, many thanks for allowing me to comment!

  706. Im no professional, but I believe you just crafted an excellent point. You obviously know what youre talking about, and I can actually get behind that. Thanks for being so upfront and so truthful.

  707. Excellent read, I just passed this onto a friend who was doing some research on that. And he actually bought me lunch as I found it for him smile Therefore let me rephrase that: Thanks for lunch! “Life is a continual upgrade.” by J. Mark Wallace.

  708. Hello, after reading this amazing article i am too happy to share my knowledge here with friends.

  709. Genuinely no matter if someone doesn’t be aware of after that its up to other people thatthey will assist, so here it happens.

  710. Hello just wanted to give you a quick heads up. The text in your post seem to be running off the screen in Firefox. I’m not sure if this is a format issue or something to do with internet browser compatibility but I figured I’d post to let you know. The layout look great though! Hope you get the issue solved soon. Cheers

  711. Very nice design and excellent subject matter, practically nothing else we require : D.

  712. п»їorder stromectol online stromectol for sale – stromectol generic

  713. Generally I don’t read article on blogs, but I would like to say that thiswrite-up very compelled me to take a look at and do so!Your writing taste has been surprised me. Thanks, quite nice post.

  714. I will immediately snatch your rss as I can not find your e-mail subscription link or newsletter service.Do you’ve any? Please let me recognise so that I may subscribe.Thanks.

  715. ivermectin pills for scabies horse wormer ivermectin

  716. I really like and appreciate your blog.Really looking forward to read more. Keep writing.

  717. If some one wants expert view concerning blogging then i recommend him/her to pay a quick visit this blog,Keep up the pleasant work.

  718. wow excellent blog for certain i will come again to study new subject matter thanks

  719. 24 hr pharmacy overseas online pharmacy – online pharmacy 365 pills

  720. I’m no longer sure the place you’re gettting your info, but good topic.I muxt spend a while studying moe or working out more.Thanks for excellent information I wass searching for this infgo formyy mission.Feel free to visit my blog post :: Pamela

  721. Very good info. Lucky me I ran across your blog by chance (stumbleupon). I have saved as a favorite for later!

  722. Remarkable things here. I am very satisfied to look your post.Thanks a lot and I’m having a look forward to contact you.Will you please drop me a e-mail?

  723. Lululemon Canada Factory Outlet Sale Online WALSH ENDORA

  724. Really enjoyed this article post.Really thank you! Great.

  725. There is certainly a great deal to find out about this topic. I love all of the points you made.

  726. I quite like looking through a post that will make people think. Also, many thanks for permitting me to comment.

  727. A fascinating discussion is definitely worth comment. I think that you ought to publish more about this subject, it might not be a taboo subject but generally people don’t speak about such issues. To the next! Cheers!!

  728. It’s actually a cool and useful piece of information. I’m satisfied that you simply shared this useful information with us. Please keep us informed like this. Thank you for sharing.

  729. Hi, all is going well here and ofcourse every one is sharing data, that’s genuinely fine, keep up writing.Feel free to surf to my blog Arctic Air Pure Chill Review

  730. ivermectin for mange in foxes deworming chickens with ivermectin

  731. I love how women on social media will argue for hours over something as trivial as the correct way to pronounce “gif.” Meanwhile, world peace remains a distant dream.

    Za vsichko ima vremene?
    https://psychesisterssoiree.blogspot.com Create a positive atmosphere in your surroundings.

  732. I’ve recently started a website, the information you offer on this website has helped me tremendously. Thanks for all of your time & work.

  733. ivermectin purchase ivermectin paste for sale ivermectin covid

  734. best online canadian pharmacy review best pharmacy school canada

  735. Sendo assim, erros nesse trajeto podem causar a impotência masculina.

  736. Aw, this was a really good post. Taking the time and actual effort to produce a good articleÖ but what can I sayÖ I put things off a whole lot and don’t manage to get nearly anything done.

  737. Thanks for sharing your info. I really appreciate your efforts and I am waiting for yournext post thanks once again.

  738. Great post. I was checking constantly this blog and I’m impressed! Extremely useful information specifically the last part 🙂 I care for such information much. I was looking for this certain info for a long time. Thank you and good luck.

  739. 2. และหลังจากนั้นให้เลือกที่เมนูการฝากเงินเพื่อเข้าสู่ระบบกระเป๋าสตางค์ออนไลน์ส่วนตัวบนเว็บไซต์ เล่นคาสิโนออนไลน์ คาสิโนออนไลน์ ง่ายๆ เพียงลงทะเบียนไม่กี่ขั้นตอนเท่านั้น

  740. Hello my family member! I want to say that this post is amazing, nice written and come with approximately all vital infos. I’d like to peer extra posts like this .

  741. I have read so many articles about the blogger lovers but thispiece of writing is genuinely a pleasant article, keep it up.

  742. Thanks for your marvelous posting! I definitely enjoyed reading it, you can be a great author.I will remember to bookmark your blog and may come back later on. Iwant to encourage you to continue your greatwriting, have a nice morning!

  743. writing an argumentative essayessay paper writing servicepersuasive writing essay

  744. I will immediately clutch your rss as I can’t to find your emailsubscription hyperlink or e-newsletter service. Do you’ve any?Kindly allow me know so that I may just subscribe.Thanks.

  745. Thanks for finally writing about > Audio Push – Eternity –Hip Hop For Good

  746. what not to take with cymbalta cymbalta interactions

  747. I just like the valuable info you provide to your articles.I’ll bookmark your blog and test again right here frequently.I’m relatively certain I’ll be told a lot of new stuff right right here!Best of luck for the next!

  748. An intriguing discussion is worth comment. I believe that you ought to write more on this subject, it may not be a taboo matter but generally folks don’t discuss such issues. To the next! All the best!!

  749. Hi there colleagues, pleasant piece of writing and fastidious arguments commented here, Iam really enjoying by these.

  750. There is definately a lot to find out about this topic.I like all of the points you’ve made.

  751. That is a very good tip especially to those fresh to the blogosphere. Simple but very accurate information… Thank you for sharing this one. A must read post!

  752. I blog quite often and I really thank you for your content. Your article has truly peaked my interest. I am going to take a note of your blog and keep checking for new information about once per week. I opted in for your RSS feed as well.

  753. I needed to thank you for this fantastic read!! I absolutely loved every bit of it. I’ve got you bookmarked to look at new things you postÖ

  754. I love reading a post that will make people think. Also, thank you for allowing me to comment!

  755. I’m originally from Dublin but now live in Edinburgh differin make skin oily AND introcude a rota of a dental nurse who goes around to primary schools and teaches kids how to brush their teeth..

  756. F*ckin’ awesome issues here. I’m very happy to peer your post. Thanks so much and i’m looking ahead to touch you. Will you please drop me a e-mail?

  757. This was a really good article. Thanks so much for creating it. I’ll return for some more.

  758. Major thanks for the blog article.Much thanks again. Great.

  759. Dead written content, Really enjoyed looking through.

  760. Hello, I log on to your new stuff regularly.Your writing style is witty, keep doing what you’re doing!

  761. hydroxychloroquine sulfate tablets what is hydroxychloroquine

  762. sıkça kullanılan sosyal platform gerçek takipçi al tavsiyesi bu satıcıdır

  763. I will immediately seize your rss feed as I can not to find your e-mail subscription hyperlink ornewsletter service. Do you’ve any? Kindly allow merecognise in order that I may subscribe.Thanks.

  764. I am so grateful for your article post.Thanks Again. Really Cool.

  765. I am really impressed along with your writing abilities as smartly as with the structure to your blog. Is that this a paid subject matter or did you modify it yourself? Anyway stay up the nice quality writing, it’s rare to look a great blog like this one these days..

  766. I appreciate you sharing this article post.Much thanks again. Awesome.

  767. Very good post. I’m dealing with a few of these issues aswell..

  768. Looking forward to reading more. Great blog article.Really looking forward to read more. Will read on…

  769. Absolutely composed subject material , thanks for selective information .

  770. This is a good tip particularly to those new to the blogosphere. Simple but very accurate infoÖ Appreciate your sharing this one. A must read post!

  771. Hi, yes this article is in fact good and I have learnedlot of things from it concerning blogging. thanks.

  772. incorporate company in Singapore says:Im thankful for the blog post.Much thanks again. Cool.Reply 11/21/2021 at 6:48 am

  773. This paragraph provides clear idea designed for the new people of blogging, that truly how to do running a blog.

  774. articles on health care doctor contact listkamagra oral jelly kaufen deutschlandkamagra uk com

  775. It’s going to be ending of mine day, except before ending I am reading this enormous post to improve my experience.

  776. It’s hard to come by well-informed people about this topic, however, youseem like you know what you’re talking about! Thanks

  777. Hi there i am kavin, its my first time to commenting anyplace, when i readthis piece of writing i thought i could also make comment dueto this brilliant post.

  778. generic provigil – modafinil side effects provigil a narcotic

  779. modalert 200 modalert modafinil side effects

  780. Real instructive and wonderful anatomical structure of subject matter, now that’s user friendly (:.My blog :: lubertsi.net

  781. Наша команда профессиональных исполнителей готова подать вам прогрессивные методы, которые не только снабдят надежную защиту от прохлады, но и подарят вашему домашнему пространству элегантный вид.
    Мы работаем с последними компонентами, гарантируя долгосрочный запас работы и блестящие результаты. Изоляция внешней обшивки – это не только сбережение на тепле, но и забота о природной среде. Энергосберегающие разработки, какие мы претворяем в жизнь, способствуют не только вашему, но и сохранению природных богатств.
    Самое основополагающее: [url=https://ppu-prof.ru/]Стоимость утепления стен домов[/url] у нас начинается всего от 1250 рублей за квадратный метр! Это доступное решение, которое метаморфозирует ваш домашний уголок в фактический тепловой местечко с минимальными тратами.
    Наши достижения – это не исключительно изоляция, это создание пространства, в где каждый аспект отразит ваш уникальный образ действия. Мы примем в расчет все ваши требования, чтобы осуществить ваш дом еще еще более дружелюбным и привлекательным.
    Подробнее на [url=https://ppu-prof.ru/]www.ppu-prof.ru[/url]
    Не откладывайте труды о своем помещении на потом! Обращайтесь к экспертам, и мы сделаем ваш помещение не только уютнее, но и модернизированным. Заинтересовались? Подробнее о наших работах вы можете узнать на сайте компании. Добро пожаловать в пространство уюта и стандартов.

  782. chloroquine over the counter hidroxicloroquina

  783. https://feeds.feedburner.com/oglasi/besplatnioglasi

  784. Makedonskite nacionalni zanaeti se del od kulturnoto nasledstvo na zemjata, prenesuvano od koleno na koleno https://feeds.feedburner.com/oglasi/BezplatniObyaviMK

    „Za da stanete komentator, treba da imate diploma za humor i magister po sarkazam!

  785. It’s truly a great and useful piece of information. I am satisfied that you shared this helpful info with us. Please keep us up to date like this. Thank you for sharing.

  786. Thank you! Terrific information. canadian pharmacy

  787. I am always invstigating online for posts that can benefit me. Thank you!

  788. Really when someone doesn’t know after that its up to other users that they will assist, so hereit occurs.

  789. Just a smiling visitant here to share the love (:, btw outstanding design and style. «Justice is always violent to the party offending, for every man is innocent in his own eyes.» by Daniel Defoe.

  790. I do believe all of the ideas you have presented in your post. They are very convincing and will definitely work. Nonetheless, the posts are too brief for starters. May you please lengthen them a bit from subsequent time? Thanks for the post.

  791. This is a great tip especially to those new to the blogosphere. Brief but very precise informationÖ Many thanks for sharing this one. A must read article!

  792. 468072 511302Thanks for the write up! Also, just a heads up, your RSS feeds arent working. Could you take a appear at that? 380751

  793. I’ve been absent for a while, but now I remember why I used to love this website. Thank you, I¦ll try and check back more often. How frequently you update your website?

  794. history essay question history of essay writing biography writers

  795. Hi, this weekend is good designed for me, because this occasion i amreading this enormous informative paragraph here atmy house.

  796. Awesome article post.Really looking forward to read more. Fantastic.

  797. That is a good tip especially to those fresh to the blogosphere. Brief but very accurate informationÖ Appreciate your sharing this one. A must read article!

  798. I blog frequently and I genuinely thank you for yourinformation. This article has really peaked my interest.I’m going to take a note of your blog and keep checkingfor new details about once a week. I opted in for yourRSS feed as well.

  799. I’d like to thank you for the efforts you have put in writing this blog.I really hope to check out the same high-grade blog posts from you later on as well.In fact, your creative writing abilities has encouraged me to get my own,personal blog now 😉

  800. Hmm is anyone else having problems with the images on this blog loading?I’m trying to figure out if its a problem on my end or if it’s the blog.Any responses would be greatly appreciated.

  801. It’s going to be ending of mine day, but before end I amreading this enormous piece of writing to increase my experience.Here is my blog post; Chinesische Medizin

  802. great issues altogether, you just received a new reader. What may you recommend about your publish that you just made a few days ago? Any certain?

  803. you have a fantastic blog right here! would you like to make some welcome blog posts on my blog?

  804. Genuinely no matter if someone doesn’t understand then its upto other people that they will assist, so here it takes place.

  805. Cheers to you, We mastered something new. Thank anyone so much. I search forward to nearby.

  806. I do not even know how I finished up here, however I believed this put up was once good. I don’t understand who you might be however definitely you are going to a famous blogger when you are not already 😉 Cheers!

  807. tinder login, tinder dating apptinder login

  808. Hi there, this weekend is nice designed for me, because this momenti am reading this enormous informative post here at my residence.

  809. An intriguing discussion is definitely worth comment. I believe that you ought to publish more about this issue, it may not be a taboo matter but generally folks don’t speak about such issues. To the next! Many thanks!!

  810. Hello! I could have sworn Iíve been to your blog before but after looking at a few of the articles I realized itís new to me. Regardless, Iím definitely delighted I discovered it and Iíll be book-marking it and checking back frequently!

  811. wszyscyklikamy says:I really enjoy the blog post.Thanks Again. Awesome.Reply 05/03/2020 at 5:39 am

  812. п»їcipro generic cipro for sale – antibiotics cipro

  813. Regards. A good amount of posts! antibiotic doxycycline

  814. Thanks for a marvelous posting! I certainly enjoyed reading it,you’re a great author. I will be sure to bookmark your blogand definitely will come back at some point. I want to encourage youcontinue your great writing, have a nice morning!

  815. It’s great that you are getting thoughts from this article as well as from our dialogue made here.

  816. I’m not positive the place you’re getting your information, however good topic.I needs to spend some time learning more or understanding more.Thank you for wonderful information I used to be searching forthis info for my mission.

  817. Wow, great blog article.Thanks Again. Great.

  818. I really like what you guys tend to be up too. This sort of clever work and coverage! Keep up the awesome works guys I’ve included you guys to my blogroll.

  819. Hmm is anyone else experiencing problems with the images on this blogloading? I’m trying to determine if its a problem on my end or if it’s the blog.Any suggestions would be greatly appreciated.

  820. Wow that was unusual. I just wrote an extremely long comment but after I clicked submit my comment didn’t show up.Grrrr… well I’m not writing all that over again. Anyway,just wanted to say fantastic blog!

  821. magnificent issues altogether, you just won a new reader.What could you recommend in regards to your submit that you made a few days ago?Any certain? asmr 0mniartist

  822. This very blog is without a doubt awesome and besides factual. I have picked many handy things out of it. I ad love to come back again and again. Thanks!

  823. Hi Brita,I definitely will. Thank you for the encouragement.Regards,Mamta

  824. Ahaa, its good conversation regarding this piece of writing here at this blog, I have read all that, so now me also commenting at this place.

  825. What a information of un-ambiguity and preserveness of valuable know-how concerning unpredicted emotions.

  826. fish hydroxychloroquine for saleexplain tardive dyskinesia electricity

  827. How To Know If You’re All Set To Pornstar UK
    Kayleigh Wanless Uk Pornstar

  828. 5 Local Accident Attorneys Projects For Every Budget accident attorney
    miami (Rory)

  829. Really appreciate you sharing this article post.Thanks Again. Will read on…

  830. It’s an amazing article designed for all the online people;they will take advantage from it I am sure.

  831. You actually make it seem so easy along with your presentation however I find this topic to be actually something which I think I’d by no means understand. It kind of feels too complicated and very large for me. I am taking a look ahead in your next put up, I will try to get the grasp of it!

  832. Some truly nice stuff on this internet site, I love it.

TOP