CSV実施はそんなに重要か

CSV実施はそんなに重要か

筆者のもとには、製薬企業、医療機器企業、ベンダー企業などから日々CSV(コンピュータ化システムバリデーション)実施についてのコンサルティング実施要請が来る。
多くの場合、規制当局の査察に備えたいからとか、顧客監査などで指摘を受けたくないからとか、単に規制要件は絶対に遵守しなければならないためという理由を述べられることが多い。
いわゆるブラインドコンプライアンス状態である。
しかしである。そもそもヘルスケア関連の規制要件の目的は、患者の安全性の担保、製品の品質の保証、製品の有効性の保証である。
査察のためにCSV文書を一式揃える(査察目的の文書化)などは本末転倒である。
一体どこを向いて仕事をしているのであろうか。

CSV実施の目的は査察対応ではない。目的と手段が逆転していることがしばしばである。
CSVは、規制の適用を受けるプロセスにコンピュータシステムを使用した際に課される。
しかしながら、コンピュータシステムは、プレディケートルール(GLP、GCP、GMP、GVP、GQP、GPSP等)の要求を満たすために、間接的に影響するものである。
直接患者の安全性、製品の品質、製品の有効性に影響する訳ではないため、CSV実施が最重要とは言えない。
CSVを実施するためには、企業はコンプライアンスコストを遣う。
しかしながら、企業が使ったコストは企業が自腹を切るのではなく、薬価や製品価格に転嫁される。
すなわち患者負担となるのである。
従って、いくらでもコンプライアンスコストを遣って良い訳ではない。
少し大げさなことを言うと、高額所得者しか救えない医療となってしまうのである。

規制要件だからとか、査察があるからとかといった理由で、やみくもにCSVを実施し、コンプライアンスコストを遣うべきではない。

まずは当該コンピュータシステムがどの程度、患者の安全性、製品の品質、製品の有効性に影響するのかを判断するべきである。
いわゆるリスクベースドアプローチである。

とりわけ、日本の企業はあらかじめ画一的な基準を設けたがる傾向にある。しかしながら、そもそもリスクベースドアプローチでは、基準というものはない。
各コンピュータシステムのバリデーションは、どの程度患者の安全性、製品の品質、製品の有効性に影響するのかによって都度基準を策定するべきなのである。

CSV実施に関する問合せがあった場合に、筆者は必ず、どのような製品であるのか、またどのビジネスエリア(非臨床試験、臨床試験、CMC、製造、製販後安全管理等)を尋ねることにしている。
その理由は、製品によってリスクが異なり、プロセスによってもリスクが異なるためである。
例えば、無菌製剤、抗がん剤、向精神薬、血液製剤、ワクチンなどの場合はリスクが高いだろう。
一方で胃腸薬、栄養剤などはリスクが低いだろう。
企業の要員は、規制当局の査察官に比べて、当該製品のプロである。
また各プロセスにおいてどのようなリスクが潜むか、どの程度リスクがあるかについても熟知しているはずである。
ぜひ、プロフェッショナルな活動を目指して頂きたい。
誰でもが出来るCSV手順書の作成や、様式の作成などはナンセンスである。

https://www.youtube.com/watch?v=cYZ8ayMuvSU

関連商品

[blogcard url= https://xn--2lwu4a.jp/qms-csv/ title=”QMS(手順書)ひな形 CSV関連” ]

Related post

Comment

  1. Thanks so much for the article post.Thanks Again. Much obliged.

  2. Really appreciate you sharing this blog.Much thanks again. Really Cool.

  3. This is one awesome blog post.Much thanks again. Awesome.

  4. I really enjoy the article post.Thanks Again. Want more.

  5. I really enjoy the blog. Keep writing.

  6. I really liked your blog post.Thanks Again. Really Cool.

  7. Enjoyed every bit of your blog post.Thanks Again. Want more.

  8. Thanks-a-mundo for the blog.Really thank you! Much obliged.

  9. Thank you for your blog article. Fantastic.

  10. Thanks again for the blog post.Much thanks again. Really Cool.

  11. Great article. Want more.

  12. Appreciate you sharing, great blog article.Much thanks again. Keep writing.

  13. Thanks for the blog.Thanks Again. Much obliged.

  14. Im obliged for the article. Really Great.

  15. Very informative post.Much thanks again. Will read on…

  16. wow, awesome article.Thanks Again. Really Cool.

  17. Im obliged for the post.Much thanks again. Keep writing.

  18. Major thanks for the post. Awesome.

  19. I am so grateful for your article post.Really thank you! Fantastic.

  20. wow, awesome article post.Thanks Again. Will read on…

  21. Looking forward to reading more. Great article.Really thank you! Want more.

  22. Thanks for sharing, this is a fantastic blog post.Much thanks again. Want more.

  23. I think this is a real great blog post.Thanks Again. Much obliged.

  24. I cannot thank you enough for the blog post.Thanks Again. Cool.

  25. A big thank you for your blog article.Thanks Again. Really Cool.

  26. I really liked your article post.Really thank you! Want more.

  27. Thanks so much for the blog article.Really thank you! Really Cool.

  28. Awesome blog.Really looking forward to read more. Keep writing.

  29. Appreciate you sharing, great blog post.Much thanks again. Will read on…

  30. Thanks so much for the post.Thanks Again. Want more.

  31. Thanks for sharing, this is a fantastic blog article.Thanks Again. Keep writing.

  32. wow, awesome post.Much thanks again. Awesome.

  33. Fantastic post. Cool.

  34. A round of applause for your article.Really looking forward to read more. Cool.

  35. I value the blog post.Really looking forward to read more.

  36. Major thankies for the blog.Really thank you! Will read on…

  37. I really like and appreciate your article post.Thanks Again. Keep writing.

  38. Muchos Gracias for your blog. Really Cool.

  39. I value the article post. Keep writing.

  40. Major thanks for the post.

  41. I really like and appreciate your blog post. Much obliged.

  42. I really enjoy the blog.Really looking forward to read more. Cool.

  43. I think this is a real great blog post.Really looking forward to read more. Much obliged.

  44. I truly appreciate this blog article.

  45. I value the blog.Much thanks again. Want more.

  46. I think this is a real great post.Really looking forward to read more. Cool.

  47. Im grateful for the article.Really thank you! Keep writing.

  48. I really like and appreciate your blog article.Much thanks again. Keep writing.

  49. Really informative article post. Much obliged.

  50. I am so grateful for your blog.Thanks Again. Will read on…

  51. Fantastic article post. Much obliged.

  52. Thanks for sharing, this is a fantastic blog. Cool.

  53. Thanks a lot for the article post.Really looking forward to read more. Fantastic.

  54. I value the blog post.Much thanks again.

  55. Thanks for the blog.Much thanks again. Awesome.

  56. Im thankful for the blog.Really thank you!

  57. I really liked your article.Thanks Again. Really Great.

  58. Thanks for sharing, this is a fantastic article post.Really looking forward to read more.

  59. Fantastic article. Will read on…

  60. I appreciate you sharing this article. Want more.

  61. Great post.Really looking forward to read more. Really Great.

  62. Say, you got a nice post. Much obliged.

  63. Great, thanks for sharing this blog.Really looking forward to read more. Fantastic.

  64. Wow, great blog.Much thanks again. Really Great.

  65. Thank you for your blog.Much thanks again. Awesome.

  66. Awesome blog post.Really looking forward to read more. Keep writing.

  67. Major thanks for the article.Much thanks again. Awesome.

  68. I really liked your post.Thanks Again.

  69. Very neat blog.Really looking forward to read more. Cool.

  70. This is one awesome blog article. Cool.

    • zenithund slew drive
    • 2023.10.16

    Say, you got a nice article post.Much thanks again. Really Great.

  71. Im obliged for the article post.Really looking forward to read more. Cool.

  72. Great, thanks for sharing this post.Really looking forward to read more. Really Great.

  73. I appreciate you sharing this article.Really thank you!

  74. Thank you ever so for you blog article. Want more.

  75. A round of applause for your blog article. Awesome.

  76. I truly appreciate this post.Really thank you! Really Cool.

  77. I value the article post.Much thanks again. Much obliged.

  78. I cannot thank you enough for the article post. Keep writing.

  79. Thanks for sharing, this is a fantastic blog.Really looking forward to read more. Awesome.

  80. Really informative blog.Really looking forward to read more. Really Great.

  81. Thank you ever so for you article post.Thanks Again. Fantastic.

  82. Looking forward to reading more. Great blog post.Much thanks again. Really Great.

  83. Very good article. Cool.

  84. Really enjoyed this article post.

  85. I think this is a real great post.Really looking forward to read more. Really Great.

  86. Thanks a lot for the article post.Really looking forward to read more. Much obliged.

  87. Very neat article.Thanks Again. Keep writing.

  88. Really appreciate you sharing this blog post. Want more.

  89. Thank you ever so for you blog.Much thanks again. Want more.

  90. Thanks so much for the post.Much thanks again. Much obliged.

  91. I really enjoy the article post.Much thanks again.

  92. Really informative article post.Really thank you! Keep writing.

  93. Very neat blog article.Really thank you! Want more.

  94. I value the post.Really thank you! Fantastic.

  95. Really appreciate you sharing this blog post.Really thank you! Awesome.

  96. Looking forward to reading more. Great article.Really thank you! Fantastic.

  97. Gratitude is a quality similar to electricity: it must be produced and discharged and used up in order to exist at all.

  98. Thank you ever so for you post.Really thank you! Great.

  99. Awesome article.Really looking forward to read more. Really Great.

  100. Appreciate you sharing, great blog article. Awesome.

  101. Great article post. Great.

  102. Major thankies for the blog.Thanks Again. Keep writing.

  103. Thanks for the article post.Really looking forward to read more. Really Cool.

  104. I cannot thank you enough for the blog post.Really thank you! Keep writing.

  105. Really informative blog article.Much thanks again. Keep writing.

  106. I really enjoy the blog article.Thanks Again. Want more.

  107. A round of applause for your article post.Thanks Again. Really Cool.

  108. Very informative blog article.Thanks Again. Awesome.

  109. I truly appreciate this blog post.Really looking forward to read more. Really Great.

  110. Hey, thanks for the article post.Really looking forward to read more. Want more.

  111. Thank you for your blog.Really looking forward to read more. Keep writing.

  112. I really liked your post.Really thank you!

  113. Fantastic post.Really thank you! Keep writing.

  114. Hey, thanks for the blog article.Thanks Again. Will read on…

  115. Great, thanks for sharing this blog.Much thanks again. Much obliged.

  116. Thank you ever so for you blog article.Really looking forward to read more. Really Cool.

  117. Wow, great article.Much thanks again. Cool.

  118. Im grateful for the blog post. Much obliged.

  119. I value the article.Really thank you!

  120. Very good blog.Really looking forward to read more. Keep writing.

  121. I appreciate you sharing this article post. Cool.

  122. Really enjoyed this article. Fantastic.

  123. I loved your blog article.Thanks Again. Awesome.

  124. I appreciate you sharing this blog article.Really looking forward to read more. Want more.

  125. wow, awesome article.

  126. Fantastic article post. Will read on…

  127. Thanks again for the article post. Awesome.

  128. Thanks again for the blog.Really thank you! Cool.

  129. Very good blog article.Thanks Again. Awesome.

  130. Very good blog post. Cool.

  131. Major thanks for the blog post. Keep writing.

  132. Very neat post.Much thanks again. Will read on…

  133. A round of applause for your blog post. Want more.

  134. Major thanks for the article post.Really thank you! Much obliged.

  135. Im grateful for the blog article.Much thanks again. Cool.

  136. Thanks a lot for the post.

  137. I really enjoy the blog article.Really thank you! Cool.

  138. Say, you got a nice blog article.Much thanks again. Keep writing.

  139. Thank you for your article. Fantastic.

  140. Muchos Gracias for your article post. Great.

  141. Really informative blog.Really thank you! Much obliged.

  142. This piece of writing will help the internet viewers for setting up new
    website or even a weblog from start to end.

  143. We are a group of volunteers and starting a brand new scheme in our community.

    Your web site provided us with valuable info to work on. You have performed a formidable activity
    and our entire neighborhood can be grateful to you.

  144. Really informative article.Much thanks again. Will read on…

  145. Im thankful for the article.Much thanks again. Cool.

  146. Really enjoyed this blog post. Great.

  147. Very good post.Much thanks again. Keep writing.

  148. hello!,I really like your writing very much! percentage we keep in touch extra approximately your article on AOL?
    I require a specialist in this house to resolve my problem.
    Maybe that is you! Taking a look forward to peer you.

  149. This is one awesome post.Really thank you! Will read on…

  150. Say, you got a nice post.Really looking forward to read more. Really Cool.

  151. Awesome article.Much thanks again. Fantastic.

  152. Say, you got a nice article post.Much thanks again.

  153. I am so grateful for your blog post.Really thank you! Really Great.

  154. Very neat blog post.Thanks Again. Great.

  155. You need to be a part of a contest for one of the greatest
    sites on the web. I will recommend this web site!

  156. Hello! I’ve been reading your blog for a long time now and
    finally got the courage to go ahead and give you a shout out from Lubbock Texas!
    Just wanted to say keep up the great job!

  157. Great blog here! Also your website loads up fast!
    What host are you using? Can I get your affiliate link to your host?
    I wish my web site loaded up as quickly as yours
    lol

  158. Hey there just wanted to give you a quick heads up.

    The words in your post seem to be running off the screen in Chrome.
    I’m not sure if this is a formatting issue or something to
    do with internet browser compatibility but I thought I’d post to let
    you know. The style and design look great though!
    Hope you get the issue fixed soon. Kudos

  159. Great, thanks for sharing this article post.Much thanks again. Want more.

  160. Really enjoyed this blog.Really looking forward to read more. Keep writing.

  161. Really appreciate you sharing this article.Thanks Again. Awesome.

  162. Major thanks for the blog article.Much thanks again. Want more.

  163. Hey, thanks for the post.Much thanks again. Keep writing.

  164. Fantastic blog.Really thank you! Cool.

  165. Thanks again for the blog.Really looking forward to read more. Will read on…

  166. Im thankful for the blog. Really Great.

  167. I appreciate you sharing this blog post.Really looking forward to read more. Great.

  168. When someone writes an piece of writing he/she retains the image of a user in his/her mind that how a user can be aware of it.
    Therefore that’s why this piece of writing is outstdanding.
    Thanks!

  169. Very neat post.Thanks Again. Much obliged.

  170. Thanks for the blog post.Thanks Again. Really Great.

  171. wow, awesome blog post.

  172. Say, you got a nice post. Much obliged.

  173. I truly appreciate this article post.Really looking forward to read more. Keep writing.

  174. Im grateful for the article.Really thank you!

  175. I cannot thank you enough for the article.Thanks Again. Great.

  176. A big thank you for your blog article.Much thanks again. Will read on…

  177. Awesome blog article.Much thanks again. Really Cool.

  178. Thanks for the article.Really looking forward to read more. Fantastic.

  179. Wow, great blog article.Thanks Again. Will read on…

  180. Thank you for your article post.Really thank you! Fantastic.

  181. Hi there I am so thrilled I found your blog, I really found you by error, while I was searching
    on Yahoo for something else, Regardless I am here now and would
    just like to say cheers for a incredible post and a all round interesting blog (I also love the theme/design),
    I don’t have time to browse it all at the moment but I have
    saved it and also added in your RSS feeds, so when I have
    time I will be back to read more, Please do keep
    up the fantastic jo.

  182. It’s actually a cool and helpful piece of info.
    I’m happy that you simply shared this useful information with us.
    Please keep us informed like this. Thank you for sharing.

  183. Write more, thats all I have to say. Literally,
    it seems as though you relied on the video to make your point.
    You clearly know what youre talking about, why waste
    your intelligence on just posting videos to your weblog when you could be giving
    us something informative to read?

  184. Thanks-a-mundo for the article post.Thanks Again. Really Cool.

  185. Very descriptive article, I liked that bit. Will there
    be a part 2?

  186. Muchos Gracias for your article post.Thanks Again. Great.

  187. Im obliged for the blog article.Thanks Again.

  188. Very informative blog article.Really looking forward to read more. Really Great.

  189. Major thankies for the blog article.Really thank you! Awesome.

  190. Im thankful for the blog post.Much thanks again. Great.

  191. Thank you ever so for you article post.Really thank you! Want more.

  192. Im obliged for the blog. Will read on…

  193. I really like and appreciate your blog post.Really looking forward to read more. Want more.

  194. I really like and appreciate your blog.

  195. Muchos Gracias for your post.Really looking forward to read more. Keep writing.

  196. Wow, great article post.Thanks Again. Fantastic.

  197. Really informative post.Really looking forward to read more. Awesome.

  198. Thanks again for the blog. Really Great.

  199. I really enjoy the article.Really looking forward to read more. Really Great.

  200. Thanks again for the blog post.Thanks Again. Fantastic.

  201. allergy over the counter drugs claritin allergy sinus 12hr costco can flonase make you sleepy

  202. Kelvin Kaemingk has over two decades of helping people make smarter decisions regarding their mortgage and money decisions. He began his career in financial planning and migrated into the mortgage space in 2002. He is passionate and committed to helping people throughout their lives, make the best financial decisions for themselves and their families. As a father of three, and now Papa K (grandpa) to one, a team builder and recruiter, Kelvin thrives on helping others realize their potential, often referenced as “Everyone’s biggest fan”. Kelvin Kaemingk is the Area Manager for loanDepot and Co-Host of the Real Estate Chalk Talk radio program based in the Minneapolis – St. Paul area. Kelvin Kaemingk, NMLS 251124 | Branch NMLS 1139048

  203. I really like and appreciate your blog. Awesome.

  204. I think this is a real great blog article. Keep writing.

  205. Im grateful for the post. Fantastic.

  206. Im obliged for the blog article.Really looking forward to read more. Keep writing.

  207. Really appreciate you sharing this article post.Really thank you! Great.

  208. wow, awesome article post.Really looking forward to read more. Keep writing.

  209. Hey, thanks for the blog post.Thanks Again. Keep writing.

  210. I truly appreciate this article.Really thank you! Great.

  211. Great post.Really thank you! Really Cool.

  212. I really enjoy the post.Really thank you! Will read on…

  213. Hi there colleagues, nice paragraph and good arguments commented here, I am in fact enjoying by
    these.

  214. Today, I went to the beach front with my kids. I found a sea
    shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She placed the shell
    to her ear and screamed. There was a hermit crab inside and it pinched her ear.
    She never wants to go back! LoL I know this is
    totally off topic but I had to tell someone!

  215. Hey! Do you know if they make any plugins to protect against hackers?
    I’m kinda paranoid about losing everything I’ve worked hard on. Any
    suggestions?

  216. I appreciate you sharing this blog.Really thank you! Great.

  217. I loved your article. Fantastic.

  218. Im obliged for the post. Awesome.

  219. Thank you ever so for you blog post.Much thanks again. Much obliged.

  220. Wow, great blog post.Really looking forward to read more. Will read on…

  221. I appreciate you sharing this blog article.Really thank you! Great.

  222. If you wish for to increase your familiarity just keep visiting this web site and be updated
    with the latest news posted here.

  223. I value the article.Much thanks again. Really Great.

  224. all the time i used to read smaller posts which as well
    clear their motive, and that is also happening with this article
    which I am reading at this place.

  225. Thank you for your blog post. Awesome.

  226. Really enjoyed this blog post.Really looking forward to read more. Keep writing.

  227. Im obliged for the blog article.Much thanks again. Will read on…

  228. Hi to all, how is the whole thing, I think every one is getting
    more from this website, and your views are good designed for
    new people.

  229. Its like you read my mind! You seem to understand a lot approximately
    this, such as you wrote the e book in it or something. I
    think that you could do with some percent to drive the message home a bit,
    but instead of that, this is great blog. A great read.
    I’ll certainly be back.

  230. Muchos Gracias for your blog.Really looking forward to read more. Keep writing.

  231. Great blog article.Much thanks again. Awesome.

  232. Very neat blog article.Thanks Again. Cool.

  233. Great post. Want more.

  234. Muchos Gracias for your blog article.Thanks Again. Fantastic.

  235. Great blog article.Really thank you! Really Great.

  236. I really liked your blog article.Really looking forward to read more. Great.

  237. Major thankies for the blog post. Awesome.

  238. Enjoyed every bit of your blog post.Much thanks again. Will read on…

  239. Major thankies for the article.Much thanks again. Really Cool.

  240. A round of applause for your blog post.Much thanks again. Keep writing.

  241. Thanks so much for the blog article. Keep writing.

  242. Im thankful for the blog article.Much thanks again. Cool.

  243. I truly appreciate this blog.Really thank you! Want more.

  244. I am so grateful for your article.Really thank you! Cool.

  245. Thanks a lot for the blog post.Really looking forward to read more. Fantastic.

  246. I value the blog post.Thanks Again. Much obliged.

  247. Thanks for the blog.Much thanks again. Great.

  248. This website is known as a stroll-via for all of the info you wished about this and didn’t know who to ask. Glimpse right here, and you’ll positively uncover it.

  249. I really liked your blog.Much thanks again. Great.

  250. A round of applause for your article.Thanks Again. Cool.

  251. Thanks-a-mundo for the article. Awesome.

  252. Thank you for your blog post.

  253. Thanks a lot for the post. Keep writing.

  254. I appreciate you sharing this blog article. Keep writing.

  255. Fantastic blog post.Really thank you! Fantastic.

  256. I loved your blog post.Much thanks again. Awesome.

  257. Hey, thanks for the blog.Really looking forward to read more. Much obliged.

  258. I truly appreciate this article. Fantastic.

  259. Fantastic blog article.Much thanks again.

  260. Great article.Really looking forward to read more. Fantastic.

  261. Major thankies for the article.Thanks Again. Will read on…

  262. Thanks for sharing, this is a fantastic post. Want more.

  263. Really appreciate you sharing this blog.Much thanks again. Will read on…

  264. Im obliged for the blog article.Really looking forward to read more. Cool.

  265. Thanks for the article.Much thanks again. Really Cool.

  266. Really informative article.Really thank you! Fantastic.

  267. Real instructive and good anatomical structure of content material, now that’s user genial (:.

  268. Im grateful for the article post.Really thank you! Want more.

  269. This is one awesome post. Really Cool.

  270. I am so grateful for your article.Really thank you! Cool.

  271. Muchos Gracias for your blog article.Thanks Again.

  272. I cannot thank you enough for the post.Much thanks again. Awesome.

  273. wonderful points altogether, you simply gained a new reader. What would you recommend in regards to your post that you made a few days ago? Any positive?

  274. Hey, thanks for the blog post.Really thank you! Want more.

  275. Looking forward to reading more. Great blog. Awesome.

  276. Very good blog article.Much thanks again.

  277. Im thankful for the article post.Much thanks again. Cool.

  278. Thanks-a-mundo for the post.Really looking forward to read more. Cool.

  279. Really informative post.Really thank you! Will read on…

  280. Major thanks for the blog post.Really thank you! Fantastic.

  281. Looking forward to reading more. Great blog post.Really looking forward to read more. Awesome.

  282. Awesome blog.Really thank you! Want more.

  283. Thank you ever so for you article.Really looking forward to read more. Want more.

  284. Awesome article.Thanks Again.

  285. Thanks for sharing, this is a fantastic post.Much thanks again. Awesome.

  286. Thanks a lot for the blog.Thanks Again. Really Cool.

  287. wow, awesome article post.Much thanks again. Will read on…

  288. A big thank you for your blog article.Really thank you! Want more.

  289. Great, thanks for sharing this blog.Really looking forward to read more. Will read on…

  290. Very informative post. Keep writing.

  291. I cannot thank you enough for the blog.Really thank you!

  292. Hey, thanks for the blog post.Really looking forward to read more. Really Great.

  293. Wow, great blog.Really looking forward to read more.

  294. Appreciate you sharing, great blog.Really thank you! Cool.

  295. Very good article.Really looking forward to read more. Want more.

  296. Major thanks for the article post.Much thanks again. Keep writing.

  297. I value the blog article. Will read on…

  298. I really liked your blog post.Really looking forward to read more. Want more.

  299. Major thanks for the post.Really looking forward to read more. Great.

  300. I really liked your blog post.Thanks Again. Really Cool.

  301. I am so grateful for your blog.Much thanks again. Much obliged.

  302. Thanks so much for the article post.Much thanks again.

  303. Enjoyed every bit of your blog post.Thanks Again. Cool.

  304. You have observed very interesting points! ps decent web site.

  305. I really enjoy the blog post.Much thanks again. Will read on…

  306. Hey, thanks for the article.Thanks Again. Great.

  307. A big thank you for your article post. Much obliged.

  308. Fantastic blog.Thanks Again.

  309. Great, thanks for sharing this article.Thanks Again. Fantastic.

  310. Keep working ,splendid job!

  311. What Is Sugar Defender? Sugar Defender is a natural blood sugar support formula created by Tom Green. It is based on scientific breakthroughs and clinical studies.

  312. I have not checked in here for a while as I thought it was getting boring, but the last several posts are great quality so I guess I’ll add you back to my daily bloglist. You deserve it my friend 🙂

  313. What Is Aizen Power? Aizen Power is presented as a distinctive dietary supplement with a singular focus on addressing the root cause of smaller phalluses

  314. I got good info from your blog

  315. Once I originally commented I clicked the -Notify me when new comments are added- checkbox and now each time a comment is added I get four emails with the same comment. Is there any means you can remove me from that service? Thanks!

  316. Hi my friend! I want to say that this post is awesome, nice written and include almost all significant infos. I?¦d like to look extra posts like this .

  317. This site is my intake, very wonderful design and style and perfect subject material.

  318. Youre so cool! I dont suppose Ive read something like this before. So good to search out somebody with some authentic ideas on this subject. realy thank you for starting this up. this website is something that is wanted on the internet, someone with just a little originality. helpful job for bringing something new to the internet!

  319. Good write-up, I am regular visitor of one?¦s site, maintain up the excellent operate, and It is going to be a regular visitor for a long time.

  320. Hello! I just would like to give a huge thumbs up for the great info you have here on this post. I will be coming back to your blog for more soon.

  321. Looking forward to reading more. Great blog.Really looking forward to read more. Will read on…

  322. Very informative blog post.Much thanks again. Really Cool.

  323. Renew is not just another sleep aid; it’s a comprehensive nutritional formula

  324. Hello I am so excited I found your weblog, I really found you by error, while I was browsing on Askjeeve for something else, Nonetheless I am here now and would just like to say many thanks for a remarkable post and a all round entertaining blog (I also love the theme/design), I don’t have time to browse it all at the moment but I have book-marked it and also added your RSS feeds, so when I have time I will be back to read a lot more, Please do keep up the fantastic work.

  325. I discovered your weblog website on google and test a number of of your early posts. Continue to maintain up the excellent operate. I just further up your RSS feed to my MSN News Reader. Looking for forward to studying extra from you afterward!…

  326. I went over this internet site and I believe you have a lot of fantastic information, bookmarked (:.

  327. Thanks for sharing excellent informations. Your web site is so cool. I am impressed by the details that you’ve on this blog. It reveals how nicely you perceive this subject. Bookmarked this website page, will come back for extra articles. You, my friend, ROCK! I found just the information I already searched everywhere and simply could not come across. What an ideal website.

  328. This blog is definitely rather handy since I’m at the moment creating an internet floral website – although I am only starting out therefore it’s really fairly small, nothing like this site. Can link to a few of the posts here as they are quite. Thanks much. Zoey Olsen

  329. I truly appreciate this post. I’ve been looking everywhere for this! Thank goodness I found it on Bing. You have made my day! Thank you again

  330. Amazing! This blog looks exactly like my old one! It’s on a entirely different topic but it has pretty much the same layout and design. Superb choice of colors!

  331. I’ve been absent for a while, but now I remember why I used to love this website. Thank you, I will try and check back more frequently. How frequently you update your site?

  332. Hello my friend! I wish to say that this post is awesome, great written and come with almost all significant infos. I would like to peer more posts like this .

  333. Saved as a favorite, I really like your blog!

  334. Hi, Neat post. There is a problem with your site in internet explorer, would check this… IE still is the market leader and a big portion of people will miss your excellent writing because of this problem.

  335. Very interesting details you have noted, thanks for posting.

  336. You completed a number of nice points there. I did a search on the issue and found most folks will consent with your blog.

  337. Very interesting points you have remarked, thankyou for posting.

  338. In the grand scheme of things you secure an A with regard to effort and hard work. Where you confused us was first on your particulars. You know, it is said, the devil is in the details… And it couldn’t be much more true here. Having said that, allow me tell you what did deliver the results. The text can be pretty convincing and this is possibly why I am taking an effort in order to opine. I do not make it a regular habit of doing that. Second, whilst I can certainly see a jumps in reasoning you come up with, I am not really confident of just how you seem to connect your ideas that help to make the actual conclusion. For the moment I shall subscribe to your position but trust in the foreseeable future you actually link the dots better.

  339. whoah this blog is magnificent i love reading your posts. Keep up the great work! You know, a lot of people are searching around for this info, you could help them greatly.

  340. Good web site! I truly love how it is simple on my eyes and the data are well written. I’m wondering how I might be notified when a new post has been made. I have subscribed to your RSS which must do the trick! Have a great day!

  341. Hello there, You’ve done an incredible job. I will definitely digg it and personally recommend to my friends. I am sure they’ll be benefited from this web site.

  342. I cling on to listening to the news bulletin speak about receiving boundless online grant applications so I have been looking around for the top site to get one. Could you tell me please, where could i get some?

  343. Would you be all in favour of exchanging hyperlinks?

  344. I was recommended this blog by my cousin. I’m not sure whether this post is written by him as nobody else know such detailed about my difficulty. You’re incredible! Thanks!

  345. Greetings I am so happy I found your blog, I really found you by error, while I was searching on Digg for something else, Regardless I am here now and would just like to say thanks for a marvelous post and a all round interesting blog (I also love the theme/design), I don’t have time to read it all at the moment but I have saved it and also included your RSS feeds, so when I have time I will be back to read much more, Please do keep up the superb work.

  346. What’s up, its fastidious paragraph about media print, we all be familiar with media is a fantastic source of information.

  347. Heya i am for the first time here. I came across this
    board and I find It truly useful & it helped me out a lot.
    I hope to give something back and help others like you
    helped me.

  348. Hi there, I found your web site via Google whilst searching for a similar matter, your web
    site got here up, it seems good. I’ve bookmarked it in my google bookmarks.

    Hi there, simply became aware of your weblog thru
    Google, and found that it is really informative. I’m gonna be careful for brussels.
    I’ll be grateful if you continue this in future. Numerous people will likely be benefited out of your writing.
    Cheers!

  349. Hello There. I found your blog using msn. That is an extremely neatly written article.
    I’ll be sure to bookmark it and return to learn extra of your useful info.
    Thank you for the post. I’ll certainly return.

  350. I was suggested this blog by my cousin. I’m not sure
    whether this post is written by him as no one else know such detailed about
    my trouble. You are amazing! Thanks!

  351. Some really superb blog posts on this web site, thankyou for contribution.

  352. Simply wanna remark on few general things, The website style is perfect, the subject material is very fantastic. “Believe those who are seeking the truth. Doubt those who find it.” by Andre Gide.

  353. Well I truly enjoyed reading it. This post provided by you is very constructive for accurate planning.

  354. I’m typically to blogging and i actually respect your content. The article has actually peaks my interest. I am going to bookmark your site and maintain checking for new information.

  355. Good day! I could have sworn I’ve been to this site before but after checking through some of the post I
    realized it’s new to me. Nonetheless, I’m definitely glad I found it and I’ll be bookmarking and checking back often!

  356. I enjoy the efforts you have put in this, thanks for all the great articles.

  357. Very great post. I simply stumbled upon your blog and wanted to mention that
    I’ve really enjoyed browsing your weblog posts. After all I will be subscribing in your
    feed and I’m hoping you write again very soon!

  358. Appreciate the recommendation. Will try it out.

  359. What is CogniCare Pro? CogniCare Pro is 100 natural and safe to take a cognitive support supplement that helps boost your memory power. This supplement works greatly for anyone of any age and without side effects

  360. I just couldn’t depart your web site prior to suggesting that I actually enjoyed the usual info a person supply in your guests? Is gonna be again often to check up on new posts

  361. Simply wanna input on few general things, The website design is perfect, the articles is very excellent. “In business school classrooms they construct wonderful models of a nonworld.” by Peter Drucker.

  362. Pretty nice post. I just stumbled upon your blog and wanted to say
    that I’ve truly enjoyed browsing your blog posts.
    After all I will be subscribing to your rss feed and I hope you write again soon!

  363. Hiya, I’m really glad I have found this information. Today bloggers publish just about gossips and net and this is actually irritating. A good website with interesting content, that’s what I need. Thanks for keeping this web site, I’ll be visiting it. Do you do newsletters? Can not find it.

  364. Well I definitely enjoyed studying it. This tip provided by you is very useful for proper planning.

  365. I like this web site so much, saved to fav. “American soldiers must be turned into lambs and eating them is tolerated.” by Muammar Qaddafi.

  366. I believe this web site holds some rattling superb information for everyone : D.

  367. This is the right blog for anybody who desires to find out about this topic. You notice so much its virtually exhausting to argue with you (not that I really would want…HaHa). You definitely put a brand new spin on a topic thats been written about for years. Nice stuff, simply nice!

  368. Hello very cool web site!! Man .. Beautiful .. Superb .. I will bookmark your web site and take the feeds also?KI am glad to seek out a lot of helpful information right here within the publish, we need develop extra techniques in this regard, thank you for sharing. . . . . .

  369. Wow, awesome weblog structure! How long have you been blogging for? you made running a blog look easy. The total look of your web site is wonderful, as smartly as the content material!

  370. When I originally commented I clicked the “Notify me when new comments are added” checkbox and now each time a
    comment is added I get three emails with the same
    comment. Is there any way you can remove me from that service?
    Thanks!

  371. I’m really enjoying the theme/design of your website. Do you ever
    run into any internet browser compatibility problems? A couple of my blog audience have complained about my blog not operating correctly in Explorer but looks great in Chrome.
    Do you have any tips to help fix this issue?

  372. It’s very simple to find out any topic on web as compared to textbooks, as I found this
    article at this web page.

  373. You are my inspiration, I own few blogs and often run out from post :). “Yet do I fear thy nature It is too full o’ the milk of human kindness.” by William Shakespeare.

  374. Great tremendous things here. I?¦m very satisfied to see your article. Thank you a lot and i’m taking a look forward to touch you. Will you please drop me a mail?

  375. I know this web page offers quality depending articles and extra
    material, is there any other site which gives these stuff in quality?

  376. Hello, I enjoy reading all of your article post.
    I like to write a little comment to support you.

  377. Thanks – Enjoyed this article, is there any way I can receive an email when you publish a new article?

  378. I think this is one of the most vital info for me. And i’m glad reading your article. However want to commentary on some normal issues, The web site taste is great, the articles is in reality nice : D. Excellent activity, cheers

  379. Well I truly enjoyed studying it. This tip procured by you is very useful for good planning.

  380. Heya i am for the first time here. I came across this board and I find It really useful & it helped me out a lot. I hope to give something back and aid others like you helped me.

  381. I just couldn’t leave your web site before suggesting that I actually enjoyed the standard information an individual provide in your visitors? Is going to be again often to check out new posts.

  382. I’m typically to running a blog and i really admire your content. The article has really peaks my interest. I am going to bookmark your website and preserve checking for brand new information.

  383. Hello. Great job. I did not anticipate this. This is a great story. Thanks!

  384. I think this is a real great article.Really looking forward to read more. Really Cool.

  385. Well I truly liked reading it. This tip provided by you is very helpful for accurate planning.

  386. It’s really a nice and useful piece of information. I am glad that you shared this useful info with us. Please keep us up to date like this. Thank you for sharing.

  387. Today, while I was at work, my cousin stole my apple ipad and tested to see if it can survive a 30 foot drop, just so she can be a youtube sensation. My apple ipad is now broken and she has 83 views. I know this is totally off topic but I had to share it with someone!

  388. I’ve been absent for a while, but now I remember why I used to love this website. Thanks, I?¦ll try and check back more frequently. How frequently you update your site?

  389. I am often to blogging and i actually admire your content. The article has really peaks my interest. I’m going to bookmark your site and hold checking for brand new information.

  390. I¦ve been exploring for a little for any high-quality articles or weblog posts in this kind of area . Exploring in Yahoo I at last stumbled upon this site. Reading this information So i am glad to express that I have an incredibly just right uncanny feeling I came upon exactly what I needed. I such a lot unquestionably will make sure to do not omit this web site and give it a glance regularly.

  391. Thank you, I’ve recently been looking for info approximately this topic for a long time and yours is the best I have found out so far. But, what about the bottom line? Are you sure concerning the source?

TOP