GMPとは

お役立ち動画

関連商品

[blogcard url=”https://ecompliance.co.jp/SHOP/O071.html” title=”【VOD】（全5コース）】改正GMPセミナーシリーズ【一括受講コース】” content=””]

[blogcard url=”https://ecompliance.co.jp/SHOP/EL-088.html” title=”【セミナービデオ】（全5コース）改正GMPセミナーシリーズ【一括受講コース】” content=””]

[blogcard url=”https://ecompliance.co.jp/SHOP/O064.html” title=”【VOD】日本一わかりやすい【超入門】改正GMP省令セミナー” content=”厚生労働省は「医薬品および医薬部外品の製造管理及び品質管理の基準に関する省令」（GMP省令）の一部を改正する省令（厚生労働省令第90号）を発出しました。
2021年8月1日の施行を予定しています。

GMPの改正に伴い、この際基礎からGMPを学びたいという方々のために『超入門改正GMP省令セミナー』を企画いたしました。
改正GMP省令では、医薬品品質システム（ICH Q10）、品質リスクマネジメント（ICH Q9）、データインテグリティ、マネジメントレビュ、品質マニュアルなどの難解な用語や概念が出てきます。
これらを日本一わかりやすく解説いたします。
1回聞いただけでは理解できない方にも、アーカイブ配信を繰り返し視聴して頂けたら、きっとGMPを熟知できるようになるでしょう。

本セミナーは、これからGMPを勉強する方にもわかりやすく、基本からお話しを致します。また既にGMPを理解されている方にも再確認して頂ける内容となっています。
本セミナーでは、品質マニュアルのサンプルも配布いたします。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/EL-081.html” title=”【セミナービデオ】日本一わかりやすい【超入門】改正GMP省令セミナー” content=”厚生労働省は「医薬品および医薬部外品の製造管理及び品質管理の基準に関する省令」（GMP省令）の一部を改正する省令（厚生労働省令第90号）を発出しました。
2021年8月1日の施行を予定しています。

GMPの改正に伴い、この際基礎からGMPを学びたいという方々のために『超入門改正GMP省令セミナー』を企画いたしました。
改正GMP省令では、医薬品品質システム（ICH Q10）、品質リスクマネジメント（ICH Q9）、データインテグリティ、マネジメントレビュ、品質マニュアルなどの難解な用語や概念が出てきます。
これらを日本一わかりやすく解説いたします。
1回聞いただけでは理解できない方にも、アーカイブ配信を繰り返し視聴して頂けたら、きっとGMPを熟知できるようになるでしょう。

本セミナーは、これからGMPを勉強する方にもわかりやすく、基本からお話しを致します。また既にGMPを理解されている方にも再確認して頂ける内容となっています。
本セミナーでは、品質マニュアルのサンプルも配布いたします。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/O060.html” title=”【VOD】改正GMP省令要点セミナー” content=”厚生労働省は「医薬品及び医薬部外品の製造管理及び品質管理の基準に関する省令」（GMP省令）の一部を改正する省令（厚生労働省令第90号 ）を発出しました。
2021年8月1日の施行を予定しています。

GMP施行通知の施行（2013年8月30日）から8年近く経過し、いよいよGMP省令が改正されます。
改正GMP省令は、ICHやPIC/S等の国際標準のGMP基準に整合されました。
特にICH-Q9（品質リスクマネジメント）やICH-Q10（医薬品品質システム）の遵守が求められます。
それにより、品質保証体制の充実が求められることとなりました。

しかしながら、改正GMP省令はPIC/S GMPとの差異も存在します。
いったい何が変わり、どういう要求事項になっているのでしょうか。

改正GMP省令は、PIC/S GMPガイドライン重要項目（6項目）に加え、おおよそ以下の要件が追加されました。

承認事項の遵守（第3条の2）
医薬品品質システム（第3条の3）
品質リスクマネジメント（第3条の4）
交叉汚染の防止（第8条の2）
安定性モニタリング（第11条の2）
製品品質の照査（第11条の3）
原料等の供給者の管理（第11条の4）
外部委託業者の管理（第11条の5）
また、用語の定義が充実しました。
例えば、「医薬品品質システム」､「品質リスクマネジメント」、「安定性モニタリング」、「最終製品」、「参考品」､「保存品」、「是正措置」、「予防措置」、「品質」などが第2条（定義）に追記されます。

いったいどのような手順書（SOP）を作成すれば良いのでしょうか。

【医薬品品質システム】
ICH Q10（医薬品品質システム）の取り込みはグローバルな流れでもあります。
したがって、改正GMP省令においては、ICH Q10の浸透が強く要求されます。
では、医薬品品質システムとはいったい何でしょうか。
医薬品品質システムにおいては、経営層（トップマネジメント）の関与が求められます。
トップマネジメントは、医薬品品質システムの確立と実施の責任を持ちます。
また、定期的にマネジメントレビュによって品質をレビュし、医薬品品質システムの見直しを実施しなければなりません。
それにより、医薬品のライフサイクル全期間での継続的改善を促進することとなります。

また、製造所においては、従来の品質部門に品質保証に係る業務を担う組織（QA）の設置が規定されます。
製造管理者の管理監督の下、品質保証に係わる業務を実際に遂行する組織としての手順書の作成と実施が求められます。
また、外部試験検査機関等の供給者管理も厳格化されます。
供給者監査の実施や供給者における変更管理も把握する必要があります。
さらに品質保証部門（QA）は、是正措置や予防措置（CAPA）を通じて、品質の改善を実施しなければなりません。

【品質リスクマネジメント】
これまでICH-Q9 「品質リスクマネジメントに関するガイドライン」は課長通知として発出されていました。
しかし、改正GMP省令においては、適切に品質リスクマネジメントが活用されるよう、ICHQ9の原則に則して手順書の作成と実施が求められます。
さらに品質リスクマネジメントの適用範囲として、「製品の製造管理及び品質管理」 だけでなく、「製造所における医薬品品質システム（PQS）」も対象となります。

本セミナーは、改正GMP省令と現行のGMP省令の対比表、品質マニュアルのサンプルなど充実した資料を配布し、分かりやすく90分間で改正GMP省令のポイントを解説いたします。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/EL-077.html” title=”【セミナービデオ】改正GMP省令要点セミナー” content=”厚生労働省は「医薬品及び医薬部外品の製造管理及び品質管理の基準に関する省令」（GMP省令）の一部を改正する省令（厚生労働省令第90号 ）を発出しました。
2021年8月1日の施行を予定しています。

GMP施行通知の施行（2013年8月30日）から8年近く経過し、いよいよGMP省令が改正されます。
改正GMP省令は、ICHやPIC/S等の国際標準のGMP基準に整合されました。
特にICH-Q9（品質リスクマネジメント）やICH-Q10（医薬品品質システム）の遵守が求められます。
それにより、品質保証体制の充実が求められることとなりました。

しかしながら、改正GMP省令はPIC/S GMPとの差異も存在します。
いったい何が変わり、どういう要求事項になっているのでしょうか。

改正GMP省令は、PIC/S GMPガイドライン重要項目（6項目）に加え、おおよそ以下の要件が追加されました。

承認事項の遵守（第3条の2）
医薬品品質システム（第3条の3）
品質リスクマネジメント（第3条の4）
交叉汚染の防止（第8条の2）
安定性モニタリング（第11条の2）
製品品質の照査（第11条の3）
原料等の供給者の管理（第11条の4）
外部委託業者の管理（第11条の5）
また、用語の定義が充実しました。
例えば、「医薬品品質システム」､「品質リスクマネジメント」、「安定性モニタリング」、「最終製品」、「参考品」､「保存品」、「是正措置」、「予防措置」、「品質」などが第2条（定義）に追記されます。

いったいどのような手順書（SOP）を作成すれば良いのでしょうか。

【医薬品品質システム】
ICH Q10（医薬品品質システム）の取り込みはグローバルな流れでもあります。
したがって、改正GMP省令においては、ICH Q10の浸透が強く要求されます。
では、医薬品品質システムとはいったい何でしょうか。
医薬品品質システムにおいては、経営層（トップマネジメント）の関与が求められます。
トップマネジメントは、医薬品品質システムの確立と実施の責任を持ちます。
また、定期的にマネジメントレビュによって品質をレビュし、医薬品品質システムの見直しを実施しなければなりません。
それにより、医薬品のライフサイクル全期間での継続的改善を促進することとなります。

また、製造所においては、従来の品質部門に品質保証に係る業務を担う組織（QA）の設置が規定されます。
製造管理者の管理監督の下、品質保証に係わる業務を実際に遂行する組織としての手順書の作成と実施が求められます。
また、外部試験検査機関等の供給者管理も厳格化されます。
供給者監査の実施や供給者における変更管理も把握する必要があります。
さらに品質保証部門（QA）は、是正措置や予防措置（CAPA）を通じて、品質の改善を実施しなければなりません。

【品質リスクマネジメント】
これまでICH-Q9 「品質リスクマネジメントに関するガイドライン」は課長通知として発出されていました。
しかし、改正GMP省令においては、適切に品質リスクマネジメントが活用されるよう、ICHQ9の原則に則して手順書の作成と実施が求められます。
さらに品質リスクマネジメントの適用範囲として、「製品の製造管理及び品質管理」 だけでなく、「製造所における医薬品品質システム（PQS）」も対象となります。

本セミナーは、改正GMP省令と現行のGMP省令の対比表、品質マニュアルのサンプルなど充実した資料を配布し、分かりやすく90分間で改正GMP省令のポイントを解説いたします。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/O053.html” title=”【VOD】GMP省令改正における「原料等の供給者管理」の対応” content=”PIC/S GMPとの6つのギャップの一つとして、今まで、施行通知で求められていたが、GMP省令が改正され、盛り込まれることになった。今後、原料等の供給者管理は、査察時の重要なポイントとして必ず確認される。しかし、原薬から原料、資材と幅広く、その品質への影響は差があり、取決めや監査について悩まれる点でもある。リスクマネジメントの概念を取り入れ、その取決めや監査のポイントを解説し、より効果的な供給者管理を実施のための手順を探る。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/EL-070.html” title=”【セミナービデオ】GMP省令改正における「原料等の供給者管理」の対応” content=”PIC/S GMPとの6つのギャップの一つとして、今まで、施行通知で求められていたが、GMP省令が改正され、盛り込まれることになった。今後、原料等の供給者管理は、査察時の重要なポイントとして必ず確認される。しかし、原薬から原料、資材と幅広く、その品質への影響は差があり、取決めや監査について悩まれる点でもある。リスクマネジメントの概念を取り入れ、その取決めや監査のポイントを解説し、より効果的な供給者管理を実施のための手順を探る。”]

Related post

Comment

  1. Really appreciate you sharing this post.Much thanks again. Really Great.

  2. Thanks for the blog.Thanks Again. Fantastic.

  3. Thanks for the blog article.Really thank you! Awesome.

  4. Great article post. Cool.

  5. A big thank you for your blog post.Much thanks again. Will read on…

  6. Enjoyed every bit of your blog.Thanks Again. Fantastic.

  7. Thanks for the article post.Really thank you! Really Cool.

  8. Really informative post.Thanks Again. Much obliged.

  9. I cannot thank you enough for the article post.Much thanks again. Really Great.

  10. Enjoyed every bit of your article post.

  11. Really enjoyed this post.Thanks Again. Fantastic.

  12. Im thankful for the blog post. Want more.

  13. Really informative blog.Much thanks again. Great.

  14. Very informative blog article.Really looking forward to read more. Want more.

  15. Thank you for your post.Really thank you! Really Cool.

  16. I value the article post.Really looking forward to read more. Really Great.

  17. I think this is a real great article.Thanks Again. Cool.

  18. I value the blog post.Really thank you! Will read on…

  19. Thanks-a-mundo for the blog post.Much thanks again. Much obliged.

  20. I really liked your blog post.Really thank you! Fantastic.

  21. Great post.Really thank you! Will read on…

  22. Very neat blog article.Really looking forward to read more. Much obliged.

  23. I really like and appreciate your blog.Much thanks again. Keep writing.

  24. Im thankful for the article post.Really looking forward to read more. Will read on…

  25. Say, you got a nice post. Fantastic.

  26. Im grateful for the article post.Really thank you! Keep writing.

  27. Say, you got a nice blog post. Really Cool.

  28. Fantastic article.Much thanks again.

  29. Im thankful for the post.Really looking forward to read more. Much obliged.

  30. I really enjoy the blog.Thanks Again. Cool.

  31. Really informative blog article. Want more.

  32. I loved your post.

  33. I truly appreciate this blog article. Really Cool.

  34. Thank you for your post.Thanks Again. Keep writing.

  35. Very informative blog article.Much thanks again. Much obliged.

  36. Really informative article post.Really looking forward to read more. Really Cool.

  37. I really like and appreciate your article. Much obliged.

  38. Major thankies for the article.Really thank you! Keep writing.

  39. wow, awesome article post.Really looking forward to read more. Really Cool.

  40. Wow, great blog post.Much thanks again. Much obliged.

  41. Thanks for sharing, this is a fantastic blog article.Really looking forward to read more. Great.

  42. Enjoyed every bit of your blog.Really looking forward to read more. Will read on…

  43. Very neat article. Much obliged.

  44. I loved your blog post.Much thanks again. Great.

  45. Really informative blog post. Great.

  46. Really informative article.Much thanks again. Really Great.

  47. wow, awesome post.Really looking forward to read more. Want more.

  48. Thank you ever so for you blog.Really looking forward to read more. Fantastic.

  49. Very neat blog.Really thank you! Want more.

  50. Thanks-a-mundo for the blog article.Thanks Again. Really Great.

  51. Enjoyed every bit of your blog.Really thank you! Want more.

  52. Thanks for sharing, this is a fantastic blog post.Thanks Again. Really Great.

  53. Im obliged for the blog article.Thanks Again. Keep writing.

  54. Thanks for the blog article.Thanks Again. Fantastic.

  55. Im grateful for the article post.

  56. Very neat blog. Much obliged.

  57. Wow, great article.Much thanks again. Really Cool.

  58. Really appreciate you sharing this blog article.Much thanks again. Really Great.

  59. Major thanks for the article post.Really thank you!

  60. A big thank you for your post.Really looking forward to read more. Awesome.

  61. Major thankies for the blog post.Really looking forward to read more. Want more.

  62. Enjoyed every bit of your blog article.Really looking forward to read more. Want more.

  63. Awesome blog.Really looking forward to read more.

  64. Appreciate you sharing, great blog post.Really thank you! Will read on…

  65. I value the article post.Thanks Again. Awesome.

  66. I really like and appreciate your article.Much thanks again. Keep writing.

  67. Great article.Thanks Again. Keep writing.

  68. Im obliged for the blog.Much thanks again. Will read on…

  69. Awesome post.Thanks Again. Want more.

  70. I really like and appreciate your blog post.Much thanks again. Great.

  71. Thanks again for the article post.Really thank you! Great.

  72. Very informative article post.Much thanks again. Fantastic.

  73. Fantastic article post.Thanks Again. Keep writing.

  74. This is one awesome blog article.Really thank you! Really Great.

  75. Very neat article. Keep writing.

  76. Thanks so much for the blog article.Really thank you! Really Great.

  77. Im thankful for the article.Much thanks again. Great.

  78. I think this is a real great article post.Thanks Again. Really Great.

  79. Wow, great post.Really thank you! Want more.

  80. Great article.Really looking forward to read more. Much obliged.

  81. Very neat article post.Really looking forward to read more. Want more.

  82. I think this is a real great article.Really thank you! Fantastic.

  83. Very neat article.Really thank you! Much obliged.

  84. Thanks again for the post.Much thanks again. Awesome.

  85. I cannot thank you enough for the blog post. Really Cool.

  86. I think this is a real great post. Fantastic.

  87. Great, thanks for sharing this blog.Really looking forward to read more. Fantastic.

  88. Really enjoyed this blog article.Really thank you! Want more.

  89. Thank you ever so for you article post.Really looking forward to read more. Really Cool.

  90. Looking forward to reading more. Great post.Thanks Again. Cool.

  91. Thanks for the blog post.Much thanks again. Cool.

  92. I cannot thank you enough for the blog article.Really thank you! Fantastic.

  93. Great blog article.Thanks Again. Awesome.

  94. A round of applause for your blog article.Thanks Again. Cool.

  95. I am so grateful for your blog.

  96. Really informative post.Much thanks again. Fantastic.

  97. I think this is a real great blog article.Thanks Again. Really Cool.

  98. Very good article post.Much thanks again. Will read on…

  99. Major thankies for the blog article. Fantastic.

  100. Enjoyed every bit of your article.Much thanks again. Really Great.

  101. A round of applause for your blog. Will read on…

  102. Really informative article post.Thanks Again. Fantastic.

  103. Thank you for your blog article. Want more.

  104. I cannot thank you enough for the article.Thanks Again. Fantastic.

  105. Hey, thanks for the article.Thanks Again. Great.

  106. Major thankies for the blog post.Thanks Again. Will read on…

  107. Thanks a lot for the blog article.Much thanks again. Cool.

  108. Very neat article post.Much thanks again. Great.

  109. Looking forward to reading more. Great blog.Really looking forward to read more. Want more.

  110. Very good blog.Really thank you! Fantastic.

  111. A round of applause for your article.Really thank you! Want more.

  112. Muchos Gracias for your blog.Thanks Again. Awesome.

  113. Really enjoyed this blog. Fantastic.

  114. I loved your post.Really thank you! Really Great.

  115. Really informative post.Really looking forward to read more. Really Great.

  116. Great, thanks for sharing this article.Thanks Again. Much obliged.

  117. Say, you got a nice post.Much thanks again. Really Great.

  118. Thank you for your article. Great.

  119. Im thankful for the blog post.Really looking forward to read more. Really Great.

  120. I cannot thank you enough for the blog post.Much thanks again. Want more.

  121. Really enjoyed this article. Great.

  122. Awesome article. Fantastic.

  123. wow, awesome article post.Really thank you! Really Cool.

  124. I am so grateful for your article.Really thank you! Really Cool.

  125. Appreciate you sharing, great article post.Really looking forward to read more. Keep writing.

  126. Enjoyed every bit of your post.Really looking forward to read more. Really Cool.

  127. I cannot thank you enough for the blog.Really thank you! Really Great.

  128. Thanks for the blog.Thanks Again. Cool.

  129. Appreciate you sharing, great post.Much thanks again. Much obliged.

  130. Fantastic article.Much thanks again. Really Great.

  131. Im obliged for the blog.Thanks Again. Keep writing.

  132. I appreciate you sharing this article post.Thanks Again. Keep writing.

  133. Awesome article post.Really thank you! Cool.

  134. Fantastic blog article.Really thank you! Really Great.

  135. I really enjoy the blog.Much thanks again. Really Cool.

  136. I really like and appreciate your article post.Much thanks again. Really Great.

  137. Really enjoyed this blog article.Really looking forward to read more. Much obliged.

  138. A big thank you for your article post.Really thank you! Want more.

  139. Very good blog post. Want more.

  140. Appreciate you sharing, great blog post. Want more.

  141. Thanks for the article post.Thanks Again. Great.

  142. Muchos Gracias for your article post.Really thank you! Awesome.

  143. Hey, thanks for the blog.Thanks Again. Really Cool.

  144. I really like and appreciate your blog article.Really thank you! Will read on…

  145. wow, awesome blog post.Really looking forward to read more. Really Great.

  146. This is one awesome blog post.Thanks Again. Awesome.

  147. A big thank you for your blog post.Much thanks again. Fantastic.

  148. Muchos Gracias for your blog article.Really thank you! Want more.

  149. I loved your article post.Thanks Again. Keep writing.

  150. Fantastic blog article.Thanks Again. Will read on…

  151. I cannot thank you enough for the post.Really looking forward to read more. Really Cool.

  152. Im grateful for the blog.Much thanks again. Cool.

  153. Im grateful for the article.Thanks Again. Great.

  154. I value the blog post.Really looking forward to read more.

  155. wow, awesome blog article.Thanks Again. Fantastic.

  156. Major thankies for the article post.Really looking forward to read more. Cool.

  157. Thank you ever so for you blog post.Really thank you! Really Cool.

  158. Looking forward to reading more. Great article. Cool.

  159. Im thankful for the post.Much thanks again. Great.

  160. Hey, thanks for the blog post. Much obliged.

  161. Say, you got a nice blog article.Really thank you! Really Cool.

  162. Major thankies for the article.Really thank you! Great.

  163. Awesome post.Really thank you! Want more.

  164. Fantastic article post.Really thank you! Cool.

  165. Major thanks for the blog.Really looking forward to read more.

  166. I cannot thank you enough for the blog article.Really looking forward to read more.

  167. Appreciate you sharing, great article post.Much thanks again. Keep writing.

  168. Really enjoyed this blog article.Much thanks again. Will read on…

  169. I think this is a real great blog article.Much thanks again. Cool.

  170. Im grateful for the article post.Thanks Again. Great.

  171. Awesome post.

  172. Major thankies for the blog article.Really looking forward to read more. Really Cool.

  173. A big thank you for your blog article. Awesome.

  174. Kelvin Kaemingk has over two decades of helping people make smarter decisions regarding their mortgage and money decisions. He began his career in financial planning and migrated into the mortgage space in 2002. He is passionate and committed to helping people throughout their lives, make the best financial decisions for themselves and their families. As a father of three, and now Papa K (grandpa) to one, a team builder and recruiter, Kelvin thrives on helping others realize their potential, often referenced as “Everyone’s biggest fan”. Kelvin Kaemingk is the Area Manager for loanDepot and Co-Host of the Real Estate Chalk Talk radio program based in the Minneapolis – St. Paul area. Kelvin Kaemingk, NMLS 251124 | Branch NMLS 1139048

  175. wow, awesome blog article.Really thank you! Cool.

  176. Appreciate you sharing, great post.Really thank you!

  177. Very neat blog.Thanks Again. Fantastic.

  178. Enjoyed every bit of your post. Will read on…

  179. Really informative article post.Really thank you! Fantastic.

  180. I truly appreciate this blog article.Thanks Again. Cool.

  181. Looking forward to reading more. Great blog.Much thanks again. Much obliged.

  182. I really like and appreciate your blog post.Much thanks again. Great.

  183. Thanks a lot for the blog post. Really Cool.

  184. Really enjoyed this post.Really looking forward to read more. Fantastic.

  185. Great article post.Really looking forward to read more. Will read on…

  186. Hey, thanks for the blog post.Really looking forward to read more. Really Great.

  187. I really like and appreciate your blog article.Much thanks again. Fantastic.

  188. Major thanks for the article.Really thank you! Awesome.

  189. Thanks for the blog.Really looking forward to read more. Cool.

  190. Thank you ever so for you article post.Much thanks again. Fantastic.

  191. Very good article post.Really thank you! Great.

  192. Very good blog.Really thank you!

  193. Looking forward to reading more. Great article post.Really thank you! Keep writing.

  194. I truly appreciate this post.Really looking forward to read more. Really Cool.

  195. Very informative blog post.Really looking forward to read more. Much obliged.

  196. I loved your blog article.Much thanks again. Really Great.

  197. A big thank you for your article post.Much thanks again. Keep writing.

  198. Great blog post.Really looking forward to read more. Really Great.

  199. I think this is a real great article. Great.

  200. Looking forward to reading more. Great blog.Thanks Again. Keep writing.

  201. Awesome article. Will read on…

  202. I really like and appreciate your article.Really looking forward to read more. Want more.

  203. I value the post.Really looking forward to read more. Keep writing.

  204. Wow, great blog.Much thanks again. Fantastic.

  205. I loved your article post.Really looking forward to read more. Much obliged.

  206. Thanks a lot for the blog article.Much thanks again. Much obliged.

  207. Great article post.Really looking forward to read more. Cool.

  208. wow, awesome blog.Thanks Again. Want more.

  209. Hey, thanks for the blog.Really looking forward to read more. Will read on…

  210. I really like and appreciate your blog.Really looking forward to read more. Really Cool.

  211. Great post about this. I’m surprised to see someone so educated in the matter. I am sure my visitors will find that very useful.

  212. I truly appreciate this article.Thanks Again. Really Cool.

  213. Very neat blog post. Fantastic.

  214. I cannot thank you enough for the blog.Thanks Again. Great.

  215. Really informative blog article. Awesome.

  216. A round of applause for your article post.Much thanks again. Great.

  217. Great, thanks for sharing this post.Really thank you! Want more.

  218. Really enjoyed this blog article.Really thank you! Cool.

  219. I really like and appreciate your article.Thanks Again. Much obliged.

  220. Major thanks for the blog post. Awesome.

  221. Major thankies for the blog post.Really looking forward to read more.

  222. I cannot thank you enough for the blog article.Really thank you! Keep writing.

  223. Muchos Gracias for your article.Really thank you! Much obliged.

  224. Im obliged for the article post. Really Great.

  225. I loved your blog article. Really Cool.

  226. Looking forward to reading more. Great article post.

  227. Really appreciate you sharing this blog.Much thanks again. Really Great.

  228. Thank you for your article post.

  229. Im thankful for the article post.Really looking forward to read more. Will read on…

  230. Very informative article.Much thanks again. Fantastic.

  231. This is one awesome post.Much thanks again. Awesome.

  232. Hey, thanks for the article.Really thank you! Want more.

  233. Thanks for sharing, this is a fantastic blog post. Fantastic.

  234. Enjoyed every bit of your blog. Want more.

  235. A big thank you for your blog post.Really looking forward to read more. Really Cool.

  236. Very informative article post.Really looking forward to read more. Really Cool.

  237. Really appreciate you sharing this article.Much thanks again. Want more.

  238. I really liked your blog.Much thanks again. Much obliged.

  239. Very good post.Much thanks again. Really Great.

  240. I appreciate you sharing this blog. Want more.

  241. Thanks for sharing, this is a fantastic article post.Much thanks again. Cool.

  242. I appreciate you sharing this article.Really looking forward to read more. Fantastic.

  243. Very neat blog.Really thank you!

  244. Really appreciate you sharing this article.Really thank you! Want more.

  245. Say, you got a nice article post. Cool.

  246. I appreciate you sharing this blog article. Much obliged.

  247. I cannot thank you enough for the blog. Will read on…

  248. Hey, thanks for the article post. Really Cool.

  249. wow, awesome post.Much thanks again. Really Great.

  250. Really appreciate you sharing this post.Thanks Again. Really Great.

  251. I really liked your blog.Really thank you! Really Cool.

  252. wow, awesome article post.Much thanks again. Really Great.

  253. Very good blog.Much thanks again. Want more.

  254. wow, awesome blog article.Thanks Again.

  255. Thanks for the blog article.Really thank you! Keep writing.

  256. I value the article.Thanks Again. Fantastic.

  257. I really like and appreciate your blog article.Really looking forward to read more. Really Great.

  258. I really like and appreciate your article post.Really thank you! Want more.

  259. Enjoyed every bit of your article post.Really looking forward to read more. Awesome.

  260. Thanks so much for the article post. Keep writing.

  261. wow, awesome blog post. Awesome.

  262. Thanks for sharing, this is a fantastic blog.Much thanks again. Cool.

  263. Very interesting info !Perfect just what I was searching for! „Neurotics build castles in the air, psychotics live in them. My mother cleans them.” by Rita Rudner.

  264. Bardzo interesujący temat, dziękuję za wysłanie wiadomości spirometr aparat do ćwiczeń spirometr aparat do ćwiczeń

  265. I am truly glad to read this blog posts which consists of lots of helpful facts, thanks for providing such information.

  266. This is a very good tip especially to those fresh to the blogosphere. Brief but very accurate info… Appreciate your sharing this one. A must read article!

  267. You actually explained that wonderfully!write my essay.com custom essay writing services best dissertation writers

  268. I really liked your blog article.Much thanks again. Really Cool.

  269. This is one awesome blog article.Much thanks again. Want more.

  270. Really enjoyed this post.Much thanks again. Really Great.

  271. I really liked your article post.Really thank you! Fantastic.

  272. Thanks for sharing, this is a fantastic blog article.Really thank you! Fantastic.

  273. Very informative article post.Much thanks again. Really Cool.

  274. Thanks a lot for the blog article.Really thank you! Great.

  275. A motivating discussion is definitely worth comment. I think that you ought to publish more about this topic, it might not be a taboo subject but typically people don’t talk about such subjects. To the next! Kind regards!!

  276. I really enjoy the blog article. Want more.

  277. fli book tutoriel linkedin 2018 Naruto Shippuden Episode 463 Gratuitement baklava club book

  278. So, when you want to place a bet decrease than $one hundred, you need to operateit out from there.

  279. Thanks for the article post.Really looking forward to read more. Keep writing.

  280. Thanks-a-mundo for the blog.Really thank you! Fantastic.

  281. I cannot thank you enough for the article post.Really thank you! Awesome.

  282. It’s enormous that you are getting ideas from this paragraphas well as from our argument made at this time.

  283. I really like and appreciate your blog article.Really looking forward to read more. Great.

  284. I enjoy, cause I discovered exactly what I used to be lookingfor. You have ended my 4 day lengthy hunt! God Bless you man. Have a nice day.Bye

  285. Thanks for finally writing about > წინასაახალწლო კონცერტი ტყიბულის თეატრში —infotkibuli.ge health foods

  286. Oh my benefits! an outstanding write-up man. Thanks However I am experiencing concern with ur rss. Don?t understand why Incapable to sign up for it. Is there anybody obtaining the same rss issue? Anyone that understands kindly react. Thnkx

  287. Muito Bom! O seu tema foi personalizado por você? ou baixou de algum lugar?O seu projeto com alguns pequenos acertos fariameu blog destacar. Por favor, se puder dizer onde vocêconseguiu seu tema compartilha comigo, ok? Desde já agradeço!

  288. Im obliged for the blog article.Really thank you! Great.

  289. Yeah … Here, as people used to say: they teach the ABC – they shout in the whole hut 🙂

  290. Muchos Gracias for your blog article.Really thank you! Cool.

  291. Im thankful for the blog post.Much thanks again. Really Great.

  292. Im obliged for the blog.Really looking forward to read more. Really Cool.

  293. Just thought i would comment and say neat design, did you code it yourself? Looks great. Just found here

  294. Say, you got a nice post.Really looking forward to read more. Fantastic.

  295. best canadian pharmacy to order from pharmacy tech courses online

  296. This is a topic that’s close to my heart… Cheers! Whereare your contact details though?

  297. skills and abilities resume cover letter for interview linkedin upload resume

  298. how much is ivermectin for humans ivermectin gold

  299. Wow! This blog looks just like my old one! It’s on a entirely different topic but it has pretty much the same page layout and design. Wonderful choice of colors!

  300. Hi there would you mind letting me know which hosting company you’re using? I’ve loaded your blog in 3 different web browsers and I must say this blog loads a lot quicker then most. Can you recommend a good web hosting provider at a honest price? Thanks, I appreciate it!

  301. Hello. impressive job. I did not expect this. This is a impressive story. Thanks!

  302. An attention-grabbing discussion is worth comment. I feel that you should write extra on this matter, it won’t be a taboo subject however usually persons are not sufficient to talk on such topics. To the next. Cheers

  303. A powerful share, I just given this onto a colleague who was doing a little bit analysis on this. And he in fact purchased me breakfast as a result of I found it for him.. smile. So let me reword that: Thnx for the treat! However yeah Thnkx for spending the time to debate this, I really feel strongly about it and love studying extra on this topic. If possible, as you turn out to be expertise, would you mind updating your blog with more details? It’s extremely useful for me. Huge thumb up for this blog put up!

  304. I like the helpful info you provide in your articles. I’ll bookmark your weblog and check again here regularly. I’m quite sure I will learn many new stuff right here! Best of luck for the next!

  305. Hi there, I found your site by way of Google even as searching for a similar matter, your web site came up, it seems to be good. I’ve bookmarked it in my google bookmarks.

  306. Wonderful work! This is the type of info that should be shared around the net. Shame on the search engines for not positioning this post higher! Come on over and visit my web site . Thanks =)

  307. Hey very cool site!! Guy .. Beautiful .. Amazing .. I’ll bookmark your site and take the feeds also…I’m glad to search out numerous useful information here in the put up, we’d like work out extra techniques on this regard, thanks for sharing. . . . . .

  308. スーパーコピーブランドspecial bearing for textile machinesFeed Grade Copper Sulfate

  309. I’m really impressed with your writing skills as well as with the layout on your blog. Is this a paid theme or did you customize it yourself? Either way keep up the excellent quality writing, it is rare to see a nice blog like this one these days..

  310. Howdy, i read your blog from time to time and i own a similar one and i was just wondering if you get a lot of spam remarks? If so how do you prevent it, any plugin or anything you can recommend? I get so much lately it’s driving me mad so any help is very much appreciated.

  311. Pretty great post. I simply stumbled upon your blog and wanted tosay that I have truly loved browsing your blog posts.Afte alll I’ll be subscribing to your feed and I hope you write again very soon!

  312. I’ve been exploring for a little bit for any high-quality articles or blog posts on this sort of area . Exploring in Yahoo I at last stumbled upon this web site. Reading this information So i’m happy to convey that I’ve a very good uncanny feeling I discovered exactly what I needed. I most certainly will make sure to do not forget this site and give it a glance on a constant basis.

  313. Howdy! I could have sworn Iíve been to your blog before but after looking at some of the posts I realized itís new to me. Nonetheless, Iím certainly pleased I stumbled upon it and Iíll be bookmarking it and checking back frequently!

  314. Muchos Gracias for your blog article.Really looking forward to read more. Fantastic.

  315. Major thankies for the article post. Keep writing.

  316. ed causes and treatment generic ed pills – ed treatments

  317. Very neat blog. Really Great.

  318. Benim 1 saat sonra geldi t?rk aktif hemdeLoading…

  319. Great, thanks for sharing this blog.Thanks Again. Keep writing.

  320. Superb post but I was wanting to know if you could writea litte more on this subject? I’d be very grateful if you could elaborate alittle bit more. Thanks!

  321. A big thank you for your blog post.Really thank you! Fantastic.

  322. wonderful issues altogether, you simply gained a emblem newreader. What would you recommend about your publish that you made a few days ago?Any sure?

  323. Enjoyed every bit of your blog post.Really looking forward to read more. Awesome.

  324. I really like and appreciate your article post. Fantastic.

  325. Hey, thanks for the article.Really looking forward to read more. Will read on…

  326. Im obliged for the blog article.Really thank you! Really Cool.

  327. Thanks for the blog post. Really Cool.

  328. This is one awesome post.

  329. slots for real money free slots slots for real money

  330. I truly appreciate this article post.Really looking forward to read more. Really Cool.

  331. Im thankful for the article.Much thanks again. Keep writing.

  332. lola vardenafil generic – ed pills male ed pills

  333. I value the post.Really looking forward to read more. Really Cool.

  334. I will right away grab your rss feed as I can’t find youre-mail subscription hyperlink or e-newsletter service.Do you’ve any? Please permit me recognizeso that I could subscribe. Thanks.

  335. augmentin sibo azithromycin abuse ciprofloxacin ironciprofloxacin hydrochloride zithromax category azithromycin dosage

  336. Really appreciate you sharing this article post.Much thanks again. Will read on…

  337. Major thanks for the blog post.Really thank you! Much obliged.

  338. Im thankful for the article.Much thanks again. Fantastic.

  339. Great, thanks for sharing this blog.Really looking forward to read more. Awesome.

  340. Thanks-a-mundo for the post.Thanks Again. Really Great.

  341. A round of applause for your article.

  342. I think this is a real great post.Really thank you! Much obliged.

  343. Say, you got a nice blog post.Much thanks again. Really Great.

  344. Nice post. I was checking continuously this blog and I am impressed!Extremely helpful information specially the last part 🙂 I care for such information much. I was looking for this certain info for a long time.Thank you and good luck.

  345. There is visibly a package to know about this. I assume you ensured nice factors in features likewise.

  346. Greetings! Very helpful advice within this article! It’s the little changes which will make the largest changes. Many thanks for sharing!

  347. I like watching TV como usar el himcolin A fencer and pentathlete in his youth, Jim Spicer was for years the star of the Commons swimming team

TOP