FDA QSR入門セミナー

1996年10月7日、FDAは、1978年の医療機器GMP規則を改正して「品質システム」（QS）（Quality System）と呼ぶ規則を公示した。
21 CFR Part 820 Quality System Regulation – QSR QSRは、ISO 13485:1996/ISO 9001:1994を基礎にして作成された。
「品質システム規則」（Quality System Regulation：21 CFR 820）は、医療機器の設計、購入、製造、包装、表示、保管、設置およびサービスで用いられる手順とこれらに対して用いられる設備および管理に関する要件を含む。
規則の定義では、品質（Quality）は安全性や性能を含めて使用適合性（Fitness-for-use）を満たすため機器の能力を支える特徴（Feature）と特質（Characteristic）の総体をいい、QSは品質管理の実施に対する組織構造、責任、手順、プロセスおよび資源をいう。

品質システム規則の一般規定は、次のようなことを定める。
・各製造業者は設計または製造される特定の医療機器に対して適切な、そしてこの規定の要件に適合する品質システムを確立し、維持しなければならない。
・規則に定める要件は最終機器が安全かつ有効であり、またFFDCAの遵守を保証する意図をもつ。 ・規則は最終機器の構成物または部品の製造業者には適用されないが、このような製造業者に対してガイダンスとしてこの規則の規定を用いることを勧める。

外国の製造業者については、アメリカに輸入される医療機器の外国製造業者が施設へのFDA査察を拒否する場合、その施設で製造される機器は法的に不良品（Adulterated product）とみなされる。
規則は、一般規定（範囲、定義、品質システム）、品質システム要件（管理責任、品質査察、従業員）、設計管理、文書管理、購入管理、確認と追跡（確認、追跡）、生産および工程管理（生産および工程管理、検査・測定・検査器具、工程バリデーション）、容認作業（受領、工程中および最終機器の容認、容認の状態）、不適合製品、是正および予防措置、表示および包装管理（機器表示、機器包装）、取扱・保管・流通・設置（取扱、保管、流通、設置）、記録（一般要件、機器マスター記録、機器歴記録、苦情ファイル）、サービング、統計技術の各項目（Subpart）を含む。

QSRの適用対象は、一部の例外を除く全クラスの医療機器である。 QSRは、クラスⅠ機器にも適用されるが、わずかに例外がある。例えば、顔弓、ラバーダム、味覚計、採尿器、弾性包帯は、QSR免除クラスⅠ機器である。 設計管理は、一部の例外を除き、クラスⅠ機器には適用されない。例外として、コンピュータソフトウェア自動化クラスⅠ機器などがある。

標題・・・Quality System Regulation: QSR（品質システム規則）
適用・・・人体用に意図された全ての医用完成機器の設計・購買・製造・包装・ラベリング・保管・取り付けおよび付帯サービス：医療機器の製造に関する基本的な要求事項
構成・・・サブパートAからOまでの15セクションに分かれている。 主な要件 ・品質システム要求事項 ・設計管理 ・文書管理
・識別およびトレーサビリティ
・生産および工程管理
・是正処置および予防処置

お役立ち動画

関連商品

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[blogcard url=”https://ecompliance.co.jp/processdocument/FDA%20CFR%20820%20QSR.html” title=”FDA QSRに沿った形のひな形です。”]

[blogcard url=https://xn--2lwu4a.jp/qms-md/ title=”QMS（手順書）ひな形　医療機器関連” ]

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  611. Одним из перспективных направлений в развитии ОЗДС является использование инновационных технологий. Например, это могут быть системы мониторинга на основе датчиков, автоматизированные системы ловли и уничтожения дератов, системы искусственного интеллекта для анализа данных и оптимизации работы системы. Инновационные технологии могут значительно повысить эффективность и точность ОЗДС, снизить затраты и минимизировать воздействие на окружающую среду.

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  613. Одним из ключевых аспектов ОЗДС является также обучение персонала, ответственного за борьбу с дератами, в правилах безопасности, применении различных методов и технологий, а также в мониторинге и контроле за эффективностью применяемых мероприятий.

  614. Важными параметрами являются плотность размещения станций мониторинга, виды и количество приманок, а также сроки замены приманок и профилактических обследований объекта.

  615. Одним из перспективных направлений в развитии ОЗДС является использование инновационных технологий. Например, это могут быть системы мониторинга на основе датчиков, автоматизированные системы ловли и уничтожения дератов, системы искусственного интеллекта для анализа данных и оптимизации работы системы. Инновационные технологии могут значительно повысить эффективность и точность ОЗДС, снизить затраты и минимизировать воздействие на окружающую среду.

  616. Принцип работы ОЗДС основан на системном подходе, который включает фазы мониторинга, локализации, оценки плотности заражения и контроля грызунов. Станции мониторинга регистрируют наличие грызунов и передают информацию на контрольно-управляющий центр. При обнаружении грызунов, производится локализация местоположения и уровня заражения. Затем, специалисты проводят оценку плотности заражения и определяют оптимальные меры по контролю и уничтожению грызунов в данном объекте. Приманки с отравляющим препаратом размещаются в определенных местах в соответствии с рекомендациями специалистов. После определенного времени, приманки заменяются и производится анализ эффективности системы. При необходимости, проводится дополнительное отравление или захват живых грызунов с помощью ловушек.

  617. Преимущества ОЗДС очевидны. Во-первых, они обеспечивают эффективную защиту зданий, сооружений и продуктов от дератов, предотвращая материальные убытки и возможные угрозы здоровью людей и животных. Во-вторых, они могут быть экологически безопасными и минимально вредными для окружающей среды, особенно при использовании физических и биологических методов. В-третьих, ОЗДС позволяют снизить зависимость от химических препаратов, что важно с учетом требований экологической безопасности и заботы о здоровье людей.

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