改正GMP省令 医薬品品質システムの要点

医薬品規制などで要求される「品質システム」（QS：Quality System）とISO 9001やISO 13485などの品質マネジメント規格で要求される「品質管理システム」（QMS：Quality Management System）は同義である。
医薬品品質システム（PQS： Pharmaceutical Quality System）はICH Q10で要求されている。
 従来ICH Q10の準拠は任意であった。しかしながら改正 GMP 省令では医薬品品質システムのインプリメンテーションは必須となった。 
品質システムとは、品質を“改善”する“仕組み”のことである。品質システム（QS）はPDCA（Plan、Do、Check、Action）が基本である。
品質システム（PDCA）が存在するということは、今日よりも明日、明日よりも明後日は品質が向上するといった保証があるということである。
ここで継続的な改善が重要となる。

PDCAのサイクルと再発防止
企業のトップ以下が全員参加で、PDCAのサイクルを回し続け、企業全体がスパイラルアッ プ するシステムを構築しなければならない。 
そのためには、内部監査と是正処置が企業の体質の強化にとってきわめて重要である。
企業体質を向上させるチャンスを自ら放棄するような原因究明の省略は厳に慎まなければならない。
同じ不適合が何度も繰り返して起きることがないような再発防止のシステム作りが大切である。
一概に単純な不適合だから単なる修正をするだけで良いとか、原因究明や再発防止をする必要がないと考えるのは企業のスパイラルアップのために得策ではない。
単純な不適合こそ、原因究明や再発防止を怠ると、モグラ叩きのようにまた同じ不適合が繰り返されてしまい、PDCAのサイクルが回らなくなってしまうのである。
医薬品品質システムにおいては、顧客苦情などの収集を行い再発防止に向けた是正措置・予防措置（CAPA）を行うこと。
是正措置で重要なことは、問題の根本的原因を調査し、それを解消することにより、再発を防止することである。ここで是正と修正は異なることに注意しなければならない。 
内部監査を実施し、潜在している問題点（つまりリスク）を自ら発見すること。内部監査は、PIC/S GMPでは「Self Inspection」（自主的な査察）と呼ばれている。
Self Inspectionは、日本の省令等では「自己点検」と訳されているが、この用語は適切ではない。Self Inspectionでは、企業自らの内部監査等によって、日々リスクを発見し、是正・予防することが重要である。つまり当局査察で指摘されるのを待って改善するのではなく、企業自らが積極的に改善活動を実施すること。
是正措置・予防措置（CAPA）や内部監査の結果は、上級経営陣にフィードバックすること。
上級経営陣が、マネジメントレビュなどによって改善指示を出し、次年度の品質目標をたてることになる。

医薬品品質システムの4つの要素 
「医薬品品質システム」は4つの要素から成る。

  1. 製造プロセスの稼働性能および製品品質のモニタリングシステム
  2. 是正措置および予防措置（CAPA）システム
  3. 変更マネジメントシステム
  4. マネジメントレビュ

上級経営陣の責任 
PIC/S GMPの“上級経営陣”（Senior Management）は、改正GMP省令では“製造業者等”と表記されているので紛らわしい。
上級経営陣とは、法人たる製造業者等の代表者を含む薬事に関する業務に責任を有する役員のことである。
上級経営陣が実効性（有効性）のある「医薬品品質システム」（PQS）の確立と実施の責任を持つ。
上級経営陣は企業を管理された状態（State of Control）に置くこと。
上級経営陣が医薬品品質システムに係る重要事項に関して責任を負う（ICH Q10）

  1. 品質方針の確立
  2. 品質目標の設定と周知および評価
  3. 適切な資源配分および従業員への教育訓練の提供
  4. マネジメントレビュの実施
  5. 情報伝達の仕組みの構築／維持

上級経営陣は、品質マニュアルを作成すること。
上級経営陣は、品質方針を作成すること。品質方針は経営方針と整合していなければならない。
上級経営陣は、各部門に年度毎に製造責任者（品質保証部門）に品質目標を立てさせること。品質方針と品質目標は整合していなければならない。
品質目標では、達成可能な目標であることと、具体的な数値とともにその達成基準が明確になっていなければならない。
例えば、顧客苦情を3ポイント減少させる、逸脱を5ポイント下げる、顧客満足度を10ポイント増加させるなどである。
上級経営陣は、製造管理者に独立した権限と責任を与えること。
上級経営陣は、適切なリソース（人、モノ、金）を準備すること。口頭で指示する（頑張りなさい。しっかりしなさい。ちゃんとやりなさい。）だけでリソースを準備しなければ、品質改善が実行できないからである。
例えば、要員を雇用する、教育訓練を実施する、コンサルタントを雇うなどである。
上級経営陣は、少なくとも年に1回のマネジメントレビュを実施すること。
マネジメントレビュは「経営者による見直し」と訳すのが適切である。 では何を見直すのかと言うと「品質システム」および「リソース」である。
上級経営陣は、品質改善に関する適切な指示を出さなければならない。

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[blogcard url=”https://ecompliance.co.jp/SHOP/O066.html” title=”【VOD】【180分で要点を学ぶ】改正GMPセミナーシリーズ 医薬品品質システム編 ” content=”2021年8月1日からGMP省令が改正されます。
改正GMP省令は、ICHやPIC/S等の国際標準のGMP基準に整合されました。
特にICH-Q9（品質リスクマネジメント）やICH-Q10（医薬品品質システム）の遵守が求められます。
それにより、品質保証体制の充実が求められることとなりました。
ICH Q10（医薬品品質システム）の取り込みはグローバルな流れでもあります。
したがって、改正GMP省令においては、ICH Q10の浸透が強く要求されます。
では、医薬品品質システムとはいったい何でしょうか。
医薬品品質システムにおいては、経営層（トップマネジメント）の関与が求められます。
トップマネジメントは、医薬品品質システムの確立と実施の責任を持ちます。
また、定期的にマネジメントレビュによって品質をレビュし、医薬品品質システムの見直しを実施しなければなりません。
それにより、医薬品のライフサイクル全期間での継続的改善を促進することとなります。
医薬品品質システムにおいては、
・マネジメントレビュ
・製造プロセスの稼働性能および製品品質のモニタリングシステム
・是正措置および予防措置システム（CAPA）
・変更マネジメントシステム
といった4本の柱から構成されています。

また、製造所においては、従来の品質部門に品質保証に係る業務を担う組織（QA）の設置が規定されました。
製造管理者の管理監督の下、品質保証に係わる業務を実際に遂行する組織としての手順書の作成と実施が求められます。
さらに品質保証部門（QA）は、是正措置や予防措置（CAPA）を通じて、品質の改善を実施しなければなりません。

本セミナーでは、難解なICH Q10を分かりやすく解説し、医薬品品質システム構築の要点をまとめます。
また、品質マニュアルのサンプルも配布いたします。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/EL-083.html” title=”【セミナービデオ】【180分で要点を学ぶ】改正GMPセミナーシリーズ 医薬品品質システム編 ” content=”2021年8月1日からGMP省令が改正されます。
改正GMP省令は、ICHやPIC/S等の国際標準のGMP基準に整合されました。
特にICH-Q9（品質リスクマネジメント）やICH-Q10（医薬品品質システム）の遵守が求められます。
それにより、品質保証体制の充実が求められることとなりました。
ICH Q10（医薬品品質システム）の取り込みはグローバルな流れでもあります。
したがって、改正GMP省令においては、ICH Q10の浸透が強く要求されます。
では、医薬品品質システムとはいったい何でしょうか。
医薬品品質システムにおいては、経営層（トップマネジメント）の関与が求められます。
トップマネジメントは、医薬品品質システムの確立と実施の責任を持ちます。
また、定期的にマネジメントレビュによって品質をレビュし、医薬品品質システムの見直しを実施しなければなりません。
それにより、医薬品のライフサイクル全期間での継続的改善を促進することとなります。
医薬品品質システムにおいては、
・マネジメントレビュ
・製造プロセスの稼働性能および製品品質のモニタリングシステム
・是正措置および予防措置システム（CAPA）
・変更マネジメントシステム
といった4本の柱から構成されています。

また、製造所においては、従来の品質部門に品質保証に係る業務を担う組織（QA）の設置が規定されました。
製造管理者の管理監督の下、品質保証に係わる業務を実際に遂行する組織としての手順書の作成と実施が求められます。
さらに品質保証部門（QA）は、是正措置や予防措置（CAPA）を通じて、品質の改善を実施しなければなりません。

本セミナーでは、難解なICH Q10を分かりやすく解説し、医薬品品質システム構築の要点をまとめます。
また、品質マニュアルのサンプルも配布いたします。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/O071.html” title=”【VOD】（全5コース）【180分で要点を学ぶ】改正GMPセミナーシリーズ【一括受講コース】 ” content=””]

[blogcard url=”https://ecompliance.co.jp/SHOP/EL-088.html” title=”【セミナービデオ】（全5コース）【180分で要点を学ぶ】改正GMPセミナーシリーズ【一括受講コース】 ” content=”厚生”]

[blogcard url=”https://ecompliance.co.jp/SHOP/O064.html” title=”【VOD】日本一わかりやすい【超入門】改正GMP省令セミナー” content=”厚生労働省は「医薬品および医薬部外品の製造管理及び品質管理の基準に関する省令」（GMP省令）の一部を改正する省令（厚生労働省令第90号）を発出しました。
2021年8月1日の施行を予定しています。

GMPの改正に伴い、この際基礎からGMPを学びたいという方々のために『超入門改正GMP省令セミナー』を企画いたしました。
改正GMP省令では、医薬品品質システム（ICH Q10）、品質リスクマネジメント（ICH Q9）、データインテグリティ、マネジメントレビュ、品質マニュアルなどの難解な用語や概念が出てきます。
これらを日本一わかりやすく解説いたします。
1回聞いただけでは理解できない方にも、アーカイブ配信を繰り返し視聴して頂けたら、きっとGMPを熟知できるようになるでしょう。

本セミナーは、これからGMPを勉強する方にもわかりやすく、基本からお話しを致します。また既にGMPを理解されている方にも再確認して頂ける内容となっています。
本セミナーでは、品質マニュアルのサンプルも配布いたします。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/EL-081.html” title=”【セミナービデオ】日本一わかりやすい【超入門】改正GMP省令セミナー” content=”厚生労働省は「医薬品および医薬部外品の製造管理及び品質管理の基準に関する省令」（GMP省令）の一部を改正する省令（厚生労働省令第90号）を発出しました。
2021年8月1日の施行を予定しています。

GMPの改正に伴い、この際基礎からGMPを学びたいという方々のために『超入門改正GMP省令セミナー』を企画いたしました。
改正GMP省令では、医薬品品質システム（ICH Q10）、品質リスクマネジメント（ICH Q9）、データインテグリティ、マネジメントレビュ、品質マニュアルなどの難解な用語や概念が出てきます。
これらを日本一わかりやすく解説いたします。
1回聞いただけでは理解できない方にも、アーカイブ配信を繰り返し視聴して頂けたら、きっとGMPを熟知できるようになるでしょう。

本セミナーは、これからGMPを勉強する方にもわかりやすく、基本からお話しを致します。また既にGMPを理解されている方にも再確認して頂ける内容となっています。
本セミナーでは、品質マニュアルのサンプルも配布いたします。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/O060.html” title=”【VOD】改正GMP省令要点セミナー” content=”厚生労働省は「医薬品及び医薬部外品の製造管理及び品質管理の基準に関する省令」（GMP省令）の一部を改正する省令（厚生労働省令第90号 ）を発出しました。
2021年8月1日の施行を予定しています。

GMP施行通知の施行（2013年8月30日）から8年近く経過し、いよいよGMP省令が改正されます。
改正GMP省令は、ICHやPIC/S等の国際標準のGMP基準に整合されました。
特にICH-Q9（品質リスクマネジメント）やICH-Q10（医薬品品質システム）の遵守が求められます。
それにより、品質保証体制の充実が求められることとなりました。

しかしながら、改正GMP省令はPIC/S GMPとの差異も存在します。
いったい何が変わり、どういう要求事項になっているのでしょうか。

改正GMP省令は、PIC/S GMPガイドライン重要項目（6項目）に加え、おおよそ以下の要件が追加されました。

承認事項の遵守（第3条の2）
医薬品品質システム（第3条の3）
品質リスクマネジメント（第3条の4）
交叉汚染の防止（第8条の2）
安定性モニタリング（第11条の2）
製品品質の照査（第11条の3）
原料等の供給者の管理（第11条の4）
外部委託業者の管理（第11条の5）
また、用語の定義が充実しました。
例えば、「医薬品品質システム」､「品質リスクマネジメント」、「安定性モニタリング」、「最終製品」、「参考品」､「保存品」、「是正措置」、「予防措置」、「品質」などが第2条（定義）に追記されます。

いったいどのような手順書（SOP）を作成すれば良いのでしょうか。

【医薬品品質システム】
ICH Q10（医薬品品質システム）の取り込みはグローバルな流れでもあります。
したがって、改正GMP省令においては、ICH Q10の浸透が強く要求されます。
では、医薬品品質システムとはいったい何でしょうか。
医薬品品質システムにおいては、経営層（トップマネジメント）の関与が求められます。
トップマネジメントは、医薬品品質システムの確立と実施の責任を持ちます。
また、定期的にマネジメントレビュによって品質をレビュし、医薬品品質システムの見直しを実施しなければなりません。
それにより、医薬品のライフサイクル全期間での継続的改善を促進することとなります。

また、製造所においては、従来の品質部門に品質保証に係る業務を担う組織（QA）の設置が規定されます。
製造管理者の管理監督の下、品質保証に係わる業務を実際に遂行する組織としての手順書の作成と実施が求められます。
また、外部試験検査機関等の供給者管理も厳格化されます。
供給者監査の実施や供給者における変更管理も把握する必要があります。
さらに品質保証部門（QA）は、是正措置や予防措置（CAPA）を通じて、品質の改善を実施しなければなりません。

【品質リスクマネジメント】
これまでICH-Q9 「品質リスクマネジメントに関するガイドライン」は課長通知として発出されていました。
しかし、改正GMP省令においては、適切に品質リスクマネジメントが活用されるよう、ICHQ9の原則に則して手順書の作成と実施が求められます。
さらに品質リスクマネジメントの適用範囲として、「製品の製造管理及び品質管理」 だけでなく、「製造所における医薬品品質システム（PQS）」も対象となります。

本セミナーは、改正GMP省令と現行のGMP省令の対比表、品質マニュアルのサンプルなど充実した資料を配布し、分かりやすく90分間で改正GMP省令のポイントを解説いたします。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/EL-077.html” title=”【セミナービデオ】改正GMP省令要点セミナー” content=”厚生労働省は「医薬品及び医薬部外品の製造管理及び品質管理の基準に関する省令」（GMP省令）の一部を改正する省令（厚生労働省令第90号 ）を発出しました。
2021年8月1日の施行を予定しています。

GMP施行通知の施行（2013年8月30日）から8年近く経過し、いよいよGMP省令が改正されます。
改正GMP省令は、ICHやPIC/S等の国際標準のGMP基準に整合されました。
特にICH-Q9（品質リスクマネジメント）やICH-Q10（医薬品品質システム）の遵守が求められます。
それにより、品質保証体制の充実が求められることとなりました。

しかしながら、改正GMP省令はPIC/S GMPとの差異も存在します。
いったい何が変わり、どういう要求事項になっているのでしょうか。

改正GMP省令は、PIC/S GMPガイドライン重要項目（6項目）に加え、おおよそ以下の要件が追加されました。

承認事項の遵守（第3条の2）
医薬品品質システム（第3条の3）
品質リスクマネジメント（第3条の4）
交叉汚染の防止（第8条の2）
安定性モニタリング（第11条の2）
製品品質の照査（第11条の3）
原料等の供給者の管理（第11条の4）
外部委託業者の管理（第11条の5）
また、用語の定義が充実しました。
例えば、「医薬品品質システム」､「品質リスクマネジメント」、「安定性モニタリング」、「最終製品」、「参考品」､「保存品」、「是正措置」、「予防措置」、「品質」などが第2条（定義）に追記されます。

いったいどのような手順書（SOP）を作成すれば良いのでしょうか。

【医薬品品質システム】
ICH Q10（医薬品品質システム）の取り込みはグローバルな流れでもあります。
したがって、改正GMP省令においては、ICH Q10の浸透が強く要求されます。
では、医薬品品質システムとはいったい何でしょうか。
医薬品品質システムにおいては、経営層（トップマネジメント）の関与が求められます。
トップマネジメントは、医薬品品質システムの確立と実施の責任を持ちます。
また、定期的にマネジメントレビュによって品質をレビュし、医薬品品質システムの見直しを実施しなければなりません。
それにより、医薬品のライフサイクル全期間での継続的改善を促進することとなります。

また、製造所においては、従来の品質部門に品質保証に係る業務を担う組織（QA）の設置が規定されます。
製造管理者の管理監督の下、品質保証に係わる業務を実際に遂行する組織としての手順書の作成と実施が求められます。
また、外部試験検査機関等の供給者管理も厳格化されます。
供給者監査の実施や供給者における変更管理も把握する必要があります。
さらに品質保証部門（QA）は、是正措置や予防措置（CAPA）を通じて、品質の改善を実施しなければなりません。

【品質リスクマネジメント】
これまでICH-Q9 「品質リスクマネジメントに関するガイドライン」は課長通知として発出されていました。
しかし、改正GMP省令においては、適切に品質リスクマネジメントが活用されるよう、ICHQ9の原則に則して手順書の作成と実施が求められます。
さらに品質リスクマネジメントの適用範囲として、「製品の製造管理及び品質管理」 だけでなく、「製造所における医薬品品質システム（PQS）」も対象となります。

本セミナーは、改正GMP省令と現行のGMP省令の対比表、品質マニュアルのサンプルなど充実した資料を配布し、分かりやすく90分間で改正GMP省令のポイントを解説いたします。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/O053.html” title=”【VOD】GMP省令改正における「原料等の供給者管理」の対応” content=”PIC/S GMPとの6つのギャップの一つとして、今まで、施行通知で求められていたが、GMP省令が改正され、盛り込まれることになった。今後、原料等の供給者管理は、査察時の重要なポイントとして必ず確認される。しかし、原薬から原料、資材と幅広く、その品質への影響は差があり、取決めや監査について悩まれる点でもある。リスクマネジメントの概念を取り入れ、その取決めや監査のポイントを解説し、より効果的な供給者管理を実施のための手順を探る。”]

[blogcard url=”https://ecompliance.co.jp/SHOP/EL-070.html” title=”【セミナービデオ】GMP省令改正における「原料等の供給者管理」の対応” content=”PIC/S GMPとの6つのギャップの一つとして、今まで、施行通知で求められていたが、GMP省令が改正され、盛り込まれることになった。今後、原料等の供給者管理は、査察時の重要なポイントとして必ず確認される。しかし、原薬から原料、資材と幅広く、その品質への影響は差があり、取決めや監査について悩まれる点でもある。リスクマネジメントの概念を取り入れ、その取決めや監査のポイントを解説し、より効果的な供給者管理を実施のための手順を探る。”]

[blogcard url=https://xn--2lwu4a.jp/qms-alex/ title=”QMS（手順書）ひな形　医薬品関連” ]

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  222. LOTTERY DEFEATER SOFTWARE

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  301. BOOSTARO REVIEW

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  306. Lottery defeater system reviews

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  311. LIPOZEM REVIEW

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  344. NEUROQUIET

  345. NEUROQUET REVIEW

  346. Alpha bites reviews

  347. Fitspresso reviews

  348. Mitolyn

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  371. MITOLYN REVIEWS

  372. ALHA BITES REVIEWS

  373. Lipozem review

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  378. MITOLY REVIEWS

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  387. ALPHA BITES REVIEW

  388. Mitolyn review

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  393. Neuroquiet review

  394. Mitolyn reviews

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  397. SUGAR DEFENDER

  398. Mitolyn

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  403. Mitolyn reviews

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  406. TONIC GREENS REVIEW

  407. Mitolyn review

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  418. Mitolyn reviews

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  420. ALPHA BITES REVIEW

  421. Mitolyn review

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  438. MITOLYN

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  440. ERECPRIME REVIEW

  441. Mitolyn

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  443. Tonic greens review

  444. Quietum plus

  445. Nagano Lean Body Tonic

  446. Nagano Lean Body Tonic Review

  447. Mitolyn review

  448. LOTTERY DEFEATER SOFTWARE

  449. ALPHA BITES REVIEWS

  450. AIZEN POWER

  451. LOTTERY DEFEATER

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  457. LOTTERY DEFEATER SOFTWARE REVIEWS

  458. DENTICORE REVIEWS

  459. DENTICORE

  460. PROSTAVIVE REVIEW

  461. PROSTAVIVE REVIEW

  462. TONIC GREENS REVIEWS

  463. MITOLYN REVIEW

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  476. Alpha Bites Review

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  485. Lottery Defeater Review

  486. PRODENTIM REVIEWS

  487. NATURAL MOUNJARO 4 INGREDIENTS

  488. Lottery Defeater

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  501. NATURAL MOUNJARO RECIPE

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  504. Billionaire Brain Wave Review

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  520. Boostaro

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  523. Lottery Defeater Review

  524. NATURAL MOUNJARO RECIPE

  525. MITOLYN

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  527. SUGAR DEFENDER REVIEWS

  528. MITOLYN REVIEWS

  529. Leanbiome review

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  541. NAGANO TONIC REVIEWS

  542. MITOLYN REVIEWS

  543. PRODENTIM REVIEW

  544. PRODENTIM REVIEWS

  545. NATURAL MOUNJARO

  546. NATURAL MOUNJARO

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  548. NATURAL MOUNJARO RECIPE 4 INGREDIENTS

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  566. POTENTSTREAM

  567. NATURAL MOUNJARO RECIPE 4 INGREDIENTS

  568. MITOLYN REVIEWS

  569. MITOLYN REVIEW

  570. PROSTAZEN REVIEW

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  599. MITOLYN

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  628. MITOLYN

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  651. ALPHA BITES

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  653. FITSPRESSO REVIEW

  654. ALPHA BITES

  655. ALPHA BITES REVIEWS

  656. ALPHA BITES REVIEWS

  657. Sight Care review

  658. FITSPRESSO REVIEW

  659. ALPHA BITES REVIEWS

  660. ALPHA BITES

  661. Lottery Defeater

  662. FITSPRESSO REVIEW

  663. NATURAL MOUNJARO RECIPE 4 INGREDIENTS

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  665. NATURAL MOUNJARO

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  675. Lottery Defeater

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  677. Herpafend

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  680. Prodentim

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  685. LOTTERY DEFEATER SOFTWARE

  686. SALT TRICK

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  696. Boostaro

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  698. NITRIC BOOST

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  700. NITRIC BOOST ULTRA REVIEWS

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  704. MITOLYN

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  711. NITRIC BOOST ULTRA

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  721. NATURAL MOUNJARO RECIPE

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  878. Boostaro

  879. THE MONEY WAVE REVIEW

  880. NATURAL MOUNJARO RECIPE

  881. NATURAL MOUNJARO RECIPE

  882. BRAZILIAN MOUNJARO RECIPE

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  894. Natural mounjaro recipe for weight loss

  895. SALT TRICK FOR MEN

  896. Nerve fresh

  897. NATURAL MOUNJARO

  898. BLUE SALT TRICK

  899. Salt trick for man growth

  900. BRAZILIAN MOUNJARO RECIPE

  901. SALT TRICK FOR MEN

  902. Leanbiome review

  903. NATURAL MOUNJARO DRINK

  904. SALT TRICK

  905. Salt trick for man

  906. ICE WATER HACK DIET

  907. Mitolyn review

  908. Salt trick for men in bed

  909. Nitric boost ultra reviews

  910. SALT TRICK

  911. Nitric boost ultra reviews

  912. SALT TRICK

  913. SALT TRICK

  914. Salt trick for men in bed

  915. Nitric Boost

  916. Blue sant trick for men

  917. SALT TRICK FOR MEN

  918. ICE WATER HACK DIET

  919. BLUE SALT TRICK

  920. Salt trick for man

  921. SALT TRICK FOR MEN

  922. ICE WATER HACK TRICK

  923. SALT TRICK

  924. Nitric Boost ultra

  925. ICE WATER HACK DIET

  926. Salt trick explained

  927. SALT TRICK

  928. ICE WATER HACK

  929. Salt trick for men in bed

  930. ICE WATER HACK DIET

  931. Salt trick explained

  932. ICE WATER HACK

  933. Ozenvitta funciona

  934. ICE WATER HACK

  935. BRAZILIAN MOUNJARO RECIPE

  936. ICE WATER HACK

  937. ICE WATER HACK

  938. Ozenvitta

  939. AQUA SCULPT REVIEWS

  940. BRAZILIAN MOUNJARO RECIPE

  941. AQUA SCULPT REVIEWS

  942. AQUA SCULPT REVIEWS

  943. ICE WATER HACK

  944. SALT TRICK

  945. AQUA SCULPT REVIEWS

  946. What’s Going down i am new to this, I stumbled upon this I have found It positively helpful and it has aided me out loads. I hope to give a contribution & help other users like its helped me. Good job.

  947. Ozenvitta funciona

  948. AQUA SCULPT REVIEWS

  949. BRAZILIAN MOUNJARO RECIPE

  950. BRAZILIAN MOUNJARO

  951. Ozenvitta reclame aqui

  952. BRAZILIAN MOUNJARO RECIPE

  953. BRAZILIAN MOUNJARO RECIPE

  954. SALT TRICK FOR MEN

  955. Salt trick for men in bed

  956. NATURAL MOUNJARO RECIPE

  957. BRAZILIAN MOUNJARO RECIPE

  958. Salt trick for man growth

  959. NATURAL MOUNJARO RECIPE

  960. Salt trick for man growth

  961. Salt trick explained

  962. SALT TRICK FOR MEN

  963. BRAZILIAN MOUNJARO RECIPE​

  964. SALT TRICK FOR MEN

  965. Blue salt trick

  966. Zencortex review

  967. SALT TRICK FOR MEN

  968. SALT TRICK

  969. BLUE SALT TRICK

  970. Salt trick for men

  971. BLUE SALT TRICK

  972. SALT TRICK FOR MEN

  973. NATURAL MOUNJARO

  974. SALT TRICK FOR MEN

  975. Zencortex review

  976. SALT TRICK FOR MEN

  977. SALT TRICK

  978. SALT TRICK

  979. SALT TRICK FOR MEN

  980. BLUE SALT TRICK

  981. SALT TRICK FOR MEN

  982. Sight care review

  983. SALT TRICK

  984. SALT TRICK

  985. ICE WATER HACK

  986. SALT TRICK

  987. BLUE SALT TRICK

  988. SALT TRICK FOR MEN

  989. SALT TRICK

  990. ICE WATER HACK

  991. SALT TRICK FOR MEN

  992. SALT TRICK

  993. Ice Water Hack for Weight Loss

  994. NATURAL MOUNJARO

  995. NATURAL MOUNJARO FOR WEIGHT LOSS

  996. NATURAL MOUNJARO FOR WEIGHT LOSS

  997. ICE WATER HACK

  998. NATURAL MOUNJARO FOR WEIGHT LOSS

  999. NATURAL MOUNJARO RECIPE

  1000. NATURAL MOUNJARO

  1001. NATURAL MOUNJARO FOR WEIGHT LOSS

  1002. NANODEFENSE PRO REVIEW

  1003. NATURAL MOUNJARO RECIPE

  1004. NANODEFENSE PRO REVIEW

  1005. NATURAL MOUNJARO

  1006. SALT TRICK

  1007. BLUE SALT TRICK

  1008. SALT TRICK

  1009. BLUE SALT TRICK

  1010. NATURAL MOUNJARO RECIPE

  1011. SALT TRICK

  1012. SALT TRICK

  1013. SALT TRICK

  1014. BLUE SALT TRICK

  1015. SALT TRICK

  1016. BLUE SALT TRICK

  1017. BLUE SALT TRICK

  1018. SALT TRICK

  1019. SALT TRICK

  1020. BLUE SALT TRICK

  1021. SALT TRICK

  1022. SALT TRICK

  1023. SALT TRICK

  1024. SALT TRICK FOR MEN

  1025. NATURAL MOUNJARO

  1026. https://www.youtube.com/watch?v=A3RESE9jE90

  1027. Tonic Greens

  1028. BLUE SALT TRICK

  1029. SALT TRICK

  1030. SALT TRICK FOR MEN IN BED

  1031. BLUE SALT TRICK

  1032. SALT TRICK FOR MEN

  1033. SALT TRICK FOR MEN

  1034. BLUE SALT TRICK

  1035. SALT TRICK

  1036. SALT TRICK

  1037. SALT TRICK

  1038. SALT TRICK

  1039. SALT TRICK

  1040. BLUE SALT TRICK

  1041. SALT TRICK

  1042. BLUE SALT TRICK

  1043. SALT TRICK

  1044. BLUE SALT TRICK

  1045. BLUE SALT TRICK

  1046. MITOLYN

  1047. MITOLYN

  1048. SALT TRICK

  1049. Sight care review

  1050. NATURAL MOUNJARO

  1051. MITOLYN REVIEWS

  1052. SALT TRICK

  1053. MITOLYN

  1054. SALT TRICK

  1055. Prodentim review

  1056. MITOLYN REVIEWS

  1057. MITOLYN REVIEW

  1058. Lottery Defeater Review

  1059. NATURAL MOUNJARO

  1060. ICE WATER HACK FOR WEIGHT LOSS

  1061. ICE HACK

  1062. SALT TRICK

  1063. NATURAL MOUNJARO

  1064. SALT TRICK FOR MEN

  1065. SALT TRICK

  1066. BLUE SALT TRICK

  1067. TURMERIC TRICK RECIPE

  1068. SALT TRICK

  1069. BLUE SALT TRICK

  1070. BLUE SALT TRICK

  1071. BLUE SALT TRICK

  1072. SALT TRICK

  1073. SALT TRICK

  1074. SALT TRICK

  1075. BLUE SALT TRICK

  1076. SALT TRICK FOR MEN

  1077. SALT TRICK

  1078. BLUE SALT TRICK

  1079. SALT TRICK

  1080. SALT TRICK

  1081. BLUE SALT TRICK

  1082. SALT TRICK FOR MEN

  1083. Mitolyn

  1084. NATURAL MOUNJARO

  1085. SALT TRICK

  1086. SALT TRICK

  1087. SALT TRICK

  1088. SALT TRICK FOR MEN

  1089. SALT TRICK

  1090. SALT TRICK FOR MEN

  1091. SALT TRICK FOR MEN

  1092. SALT TRICK

  1093. SALT TRICK

  1094. SALT TRICK

  1095. SALT TRICK FOR MEN

  1096. SALT TRICK FOR MEN

  1097. SALT TRICK

  1098. SALT TRICK FOR MEN

  1099. SALT TRICK FOR MEN

  1100. SALT TRICK

  1101. ICE WATER HACK WEIGHT LOSS

  1102. SALT TRICK

  1103. ICE HACK RECIPE

  1104. ICE WATER HACK WEIGHT LOSS

  1105. SALT TRICK FOR MEN

  1106. Tonic Greens review

  1107. ICE HACK DIET

  1108. ICE HACK RECIPE

  1109. SALT TRICK FOR MEN

  1110. SALT TRICK

  1111. ICE HACK DIET

  1112. ICE WATER HACK WEIGHT LOSS

  1113. ICE WATER HACK WEIGHT LOSS

  1114. SALT TRICK

  1115. SALT TRICK

  1116. SALT TRICK FOR MEN

  1117. SALT TRICK FOR MEN

  1118. SALT TRICK FOR MEN

  1119. SALT TRICK

  1120. SALT TRICK

  1121. SALT TRICK

  1122. SALT TRICK

  1123. SALT TRICK FOR MEN

  1124. LOTTO CHAMP

  1125. SALT TRICK

  1126. LOTTO CHAMP REVIEWS

  1127. SALT TRICK FOR MEN

  1128. LOTTO CHAMP

  1129. SALT TRICK

  1130. SALT TRICK FOR MEN

  1131. LOTTO CHAMP REVIEWS

  1132. Sight care review

  1133. SALT TRICK

  1134. SALT TRICK

  1135. SALT TRICK FOR MEN

  1136. Tonic Greens

  1137. SALT TRICK

  1138. SALT TRICK

  1139. SALT TRICK

  1140. SALT TRICK FOR MEN

  1141. Mitolyn review

  1142. Lottery defeater review

  1143. Lottery defeater

  1144. Boostaro

  1145. SALT TRICK

  1146. TURMERIC HACK FOR WEIGHT LOSS

  1147. SALT TRICK

  1148. TURMERIC HACK

  1149. SALT TRICK

  1150. SALT TRICK

  1151. SALT TRICK FOR MEN

  1152. Natural Mounjaro

  1153. SALT TRICK FOR MEN

  1154. SALT TRICK

  1155. Natural Mounjaro recipe

  1156. Статья содержит разнообразные факты и аргументы, представленные в объективной манере.

  1157. TURMERIC HACK

  1158. TURMERIC HACK TO WEIGHT LOSS

  1159. TURMERIC HACK RECIPE

  1160. Автор статьи представляет разнообразные точки зрения и аргументы, оставляя решение оценки информации читателям.

  1161. SALT TRICK

  1162. SALT TRICK

  1163. SALT TRICK

  1164. SALT TRICK FOR MEN

  1165. SALT TRICK FOR MEN

  1166. SALT TRICK FOR MEN

  1167. SALT TRICK

  1168. SALT TRICK FOR MEN

  1169. COFFEE LOOPHOLE RECIPE

  1170. SALT TRICK

  1171. Sight care

  1172. SALT TRICK

  1173. SALT TRICK FOR MEN

  1174. Java Burn

  1175. SALT TRICK FOR MEN

  1176. SALT TRICK FOR MEN

  1177. Я оцениваю использование автором разнообразных источников, чтобы подтвердить свои утверждения.

  1178. SALT TRICK

  1179. SALT TRICK FOR MEN

  1180. Prodentim

  1181. SALT TRICK

  1182. SALT TRICK FOR MEN

  1183. SALT TRICK FOR MEN

  1184. SALT TRICK

  1185. SALT TRICK FOR MEN

  1186. SALT TRICK FOR MEN

  1187. SALT TRICK

  1188. APPLE PEEL HACK RECIPE

  1189. ICE WATER HACK

  1190. ICE HACK

  1191. SALT TRICK

  1192. APPLE PEEL TRICK

  1193. ICE WATER HACK

  1194. Prodentim review

  1195. APPLE PEEL HACK FOR WEIGHT LOSS

  1196. SALT TRICK FOR MEN

  1197. SALT TRICK FOR MEN

  1198. APPLE PEEL HACK

  1199. SALT TRICK

  1200. SALT TRICK FOR MEN

  1201. Leanbiome review

  1202. SALT TRICK FOR MEN

  1203. APPLE PEEL HACK FOR WEIGHT LOSS

  1204. Leanbiome review

  1205. Надеюсь, вам понравятся и эти комментарии! Это сообщение отправлено с сайта GoToTop.ee

  1206. Prodentim review

  1207. Мне понравилось разнообразие и глубина исследований, представленных в статье.

  1208. I don’t know if it’s just me or if everybody else encountering problems with your website. It seems like some of the text in your content are running off the screen. Can somebody else please comment and let me know if this is happening to them as well? This could be a problem with my internet browser because I’ve had this happen before. Appreciate it

  1209. Zencortex review

  1210. Boostaro

  1211. I have been surfing online more than 4 hours today, yet I never found any interesting article like yours. It is pretty worth enough for me. In my view, if all web owners and bloggers made good content as you did, the web will be a lot more useful than ever before.

  1212. NATURAL MOUNJARO

  1213. Статья предоставляет разнообразные исследования и мнения экспертов, обеспечивая читателей нейтральной информацией для дальнейшего рассмотрения темы.

  1214. BRAZILIAN MOUNJARO RECIPE

  1215. BRAZILIAN MOUNJARO RECIPE

  1216. BRAZILIAN MOUNJARO RECIPE

  1217. NATURAL MOUNJARO RECIPE

  1218. NATURAL MOUNJARO

  1219. NATURAL MOUNJARO

  1220. MITOLYN

  1221. MITOLYN REVIEW

  1222. Мне понравилась организация информации в статье, которая делает ее легко восприимчивой.

  1223. MITOLYN REVIEWS

  1224. Sight care

  1225. Today, I went to the beach front with my children. I found a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She put the shell to her ear and screamed. There was a hermit crab inside and it pinched her ear. She never wants to go back! LoL I know this is totally off topic but I had to tell someone!

  1226. LOTTERY DEFEATER

  1227. LOTTERY DEFEATER

  1228. LOTTERY DEFEATER SOFTWARE

  1229. MITOLYN REVIEW

  1230. LOTTERY DEFEATER SOFTWARE

  1231. LOTTERY DEFEATER

  1232. LOTTERY DEFEATER SOFTWARE

  1233. LOTTERY DEFEATER SOFTWARE

  1234. MITOLYN REVIEWS

  1235. Sight care review

  1236. LOTTERY DEFEATER REVIEWS

  1237. NATURAL MOUNJARO

  1238. NATURAL MOUNJARO

  1239. MITOLYN REVIEWS

  1240. NATURAL MOUNJARO RECIPE

  1241. LOTTERY DEFEATER REVIEWS

  1242. NATURAL MOUNJARO

  1243. NATURAL MOUNJARO RECIPE

  1244. Great blog you’ve got here.. It’s difficult to find excellent writing like yours nowadays. I truly appreciate people like you! Take care!!

  1245. Nagano Lean Body Tonic

  1246. NATURAL MOUNJARO RECIPE

  1247. ICE WATER HACK

  1248. MITOLYN REVIEW

  1249. ICE WATER HACK

  1250. SALT TRICK FOR MEN

  1251. SALT TRICK

  1252. ICE WATER HACK FOR WEIGHT LOSS

  1253. MITOLYN REVIEW

  1254. SALT TRICK FOR MEN

  1255. ICE WATER HACK

  1256. ICE WATER HACK

  1257. SALT TRICK FOR MEN

  1258. ICE WATER HACK FOR WEIGHT LOSS

  1259. NATURAL MOUNJARO RECIPE

  1260. I really like reading an article that will make men and women think. Also, thank you for permitting me to comment!

  1261. ICE WATER HACK

  1262. SALT TRICK

  1263. ICE WATER HACK FOR WEIGHT LOSS

  1264. SALT TRICK

  1265. ICE WATER HACK

  1266. MITOLYN

  1267. SALT TRICK

  1268. ICE WATER HACK

  1269. ICE WATER HACK

  1270. Я оцениваю широкий охват темы в статье.

  1271. SALT TRICK

  1272. ICE WATER HACK FOR WEIGHT LOSS

  1273. SALT TRICK

  1274. MITOLYN REVIEWS

  1275. ICE WATER HACK

  1276. ICE WATER HACK FOR WEIGHT LOSS

  1277. Статья основана на объективных данных и исследованиях.

  1278. ICE WATER HACK FOR WEIGHT LOSS

  1279. ICE WATER HACK

  1280. NATURAL MOUNJARO

  1281. ICE WATER HACK FOR WEIGHT LOSS

  1282. ICE WATER HACK FOR WEIGHT LOSS

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