出版記念講演会（2008年10月7日）セミナー　ご質問の回答

出版記念講演会セミナー（2008年10月7日）にて寄せられたご質問の回答のページです。

＊万が一文中に解釈の間違い等がありましても、当社では責任をとりかねます。
　本文書の改訂は予告なく行われることがあります。

* 本ページは作成途上です。日々更新を行います。（最終更新日2008年10月18日

ご質問の回答

  1. 厚労省ER/ES指針とPart11の相違について
  • Part11, Annex11（改訂版）、厚労省ERES指針の一番の違いは何ですか？
  • Part11と日本ER/ESの違いは何ですか？
  • P37のスライドで「Part11と厚労省ER/ES指針は整合していない」との説明がありましたが両者の違いを教えて下さい。
  1. 厚労省ER/ES指針は、審査管理課が作成しました。一般にCSVやPart11やANNEX11といったバリデーションやER/ES規則は、品質（GMP）側が作成します。
    厚労省ER/ES指針は、もともとeCTDにおける申請資料の信頼性を確保する目的でドラフトされました。その対象は資料及び原資料です。

    厚労省ER/ES指針と21 CFR Part 11の違いを表にまとめました。
 厚労省ER/ES指針21 CFR Part11備考
スコープ申請等に係る「資料」および「原資料」プレディケート・ルールによって管理することが要求されている記録*1
電子記録に対する要件「真正性」「見読性」「保存性」Authenticity、Integrity、Confidentiality、見読性、検索性「機密性」
ハイブリッドシステムに関する要件記述なし容認 
バックアップ要件あり明確な記載なし「Computerized System Used in Clinical Trials」には記述あり
電子署名電子署名法に基づく電子署名ユーザID＋パスワードによる（バイオメトリックス）監査証跡により改ざんを発見
手書き署名又は捺印と同等のものとして行われる署名（省令44号7条）法的拘束力のある署名行為 
アプローチなしリスクベースド
「電子記録」は「プレディケートルール」に従って運用すること		Scope & Application
出力「ディスプレイ」「印刷」「記録媒体へのコピー」など「ディスプレイ」および「印刷」および「記録媒体へのコピー」 

上へ戻る

  1. Annex11改定のきっかけ（背景は）何？
  1. 冒頭に、「Annex11はコンピュータ化システムの使用と複雑性の増加に対応し最新にした。」とあります。
    さらに現在のANNEX11は、
    ・1990年代初頭に発行されており、古いこと
    ・たった2ページで簡潔すぎること
    ・電子化が進み、査察に対してより詳細な要件が必要となったこと
    ・GMPの第4章 documentationも改定することとなった
    などでしょうか。

上へ戻る

  1. リスクベースドアプローチに関連しての質問です。
    データレビューのためのツールをバリデーションする時にカテゴリーを決めておいてバリデーションの負荷をなくし効率を上げようとしています。実際には、スタンダードとそれ以外の2つでカテゴリーを分けてバリデーションを実施するように計画する場合に考えておいた方が良いことを教えて下さい。スタンダードは、薬品ごとではなく共通で使用するものとして共通のバリデートの資料を残し、他のカスタマイズを実施した部分は、その部分のバリデートを実施しています。なお、カテゴリーは、重大さと頻度等も考慮に入れています。他に具体的例があれば教えて下さい。
  1. ご質問はリスクベースドアプローチのことではないように思います。スタンダーとそれ以外の２つだけでリスクアセスメントができるわけではありません。リスクベースドアプローチは、すべてのコンピュータ化システムに対して相対的に順位を決め、リスクの高いものから順に対応を図るというものです。
    なおリスクは、データの完全性、製品の品質、患者の安全に影響する度合（重大さ）や、規模、複雑さ、そして目新しさなどによって評価されるものです。
    なお新しいものには必ず欠陥が潜む、というのがGAMP 5で採用しているFMEAというリスクマネージメントの考え方です。

上へ戻る

  1. Part11 , Annex11の対象に苦情処理などのデータも含まれますか？
  1. 含まれます。
    CAPAは、GAMP 5でも取り上げられ、FDAが重点的に査察を行っている領域でもあります。

上へ戻る

  1. スライド29　GCP、GLPに対する要件はありますか。GMPが包含しているということでしょうか。
  1. GCP、GLPにもコンピュータ化システムに関する記述はあります。（日本、米国も同様です。）

上へ戻る

  1. 監査証跡について
  • 監査証跡を残す為にどのようなアプリケーションが良いでしょうか？
  • 報告書を作成、承認する場合。品質を保つ為に手順書の改定履歴（必要？）
  • メールを利用して、承認履歴を残す方法をどのように思われますか？
  • CSVは実施しているものの、想定しなかったケースでシステムの不具合があり監査証跡が落ちた場合、どのような対応が望ましいですか？
  • 例えば、パッケージシステムのDBに読み込み専用でレポーティングツールを使用している場合、「記録を修正しないので監査証跡まではいらないがアクセスログのみ取得する」という解釈は正しいですか？
  • スライド7：臨床検査データ
    audit trailは「computerによりgenerateされなければならない」とスライドにあります。FDAの「Computerized System Used in Clinical Investigations」ではその通り記載されていますが「Part11（2003年Final）Scope & Application」にはそこまで記載されていないように思われます。監査の際「アドバイス」はできますが「Observation」とまではしづらいと思います。（実際どこに書いてあるんだと言われました。海外での話）
    スライド10：Audit trailの代わりに修正がある毎にデータ（臨床検査データ）を紙に打ち出して電子は消去されます。監査の際「Observation」とすると「Part11 Scope & Application」を楯に「紙で問題ない」（理由、日付、finalのサインあり）と主張されます。（これも海外venderの話）
    上記2つに関し（根本は同一です）コメントを頂けたらと思います。NGなのは理解してりますがVendor＝Laboratoryを理解させるのに（新たに機能を追加するとお金もかかりますし）苦労しております。
  • 電子記録の監査証跡の他に、システムに誰がログインして、何時ログアウトした、又はシステムのポリシーの変更等の記録も存在するが、このシステムの証跡のデータの取り扱いはどの様にするのか？原資料の電子記録と同様の取り扱いか？
  1. 監査証跡（ここでは修正証跡）について、誤解が多いようです。
    修正証跡は、人が操作し、データを変更できる機能に対して自動的に採取する必要があります。
    つまり測定機器等のデータは対象でないことが多いです。（オペレータが修正できる場合は除く）
    またデータをロックする機能がある場合、ロック後は修正証跡はとりません。
    CD-Rのように修正が不可能な媒体に対しても、修正証跡はとりません。（というよりとれません。）
    さらに辞書、コード、ユーザ登録等に関しても、修正証跡はとりません。

    Part11では、監査証跡はコンピュータが自動生成することと§11.10(e)に記載があります。

上へ戻る

  1. バックアップについて
    紙が原本、スタンドアロン（例：HPLC１台）の分析機器の場合、バックアップの方法としてはCD-Rが考えられるが、劣化を考えた場合他の良い方法はあるか？CD-Rを焼き直すのか？
  1. 紙が原本でしたら、バックアップは不要です。
    電子を原本にする場合、事前にどの電子記録が原本であるかを特定しなければなりません。その原本に対してバックアップを行ってください。バックアップは原本にはなり得ませんので注意してください。バックアップはあくまでも原本が災害時などに失われた際に復旧させるものであって、電子記録を保存しておくものではありません。したがってバックアップは日々作成されるべきもので、劣化対策はほとんど必要ありません。
    ご質問の趣旨が、バックアップではなくて、電子原本の保管であるならば、話は違います。CD-Rを電子原本と定義する場合、劣化対策は必須です。CD-Rの保証期間（おおむね10年）以内に新しいメディアに移行させなければなりません。
    CD-Rは安価ですが、このようにいずれは手間がかかってしまします。従って、電子データを原本として運用する場合は、LIMSなどのデータベースの導入が望まれます。

上へ戻る

  1. 査察
  • 今後の厚労省がグローバルスタンダードでの査察を実施する事になった時に、例えば査察においてCSVに重要な問題が指摘された場合、新薬の申請等の審査等にどのような影響がありますか？
  • GCPにおいて、統計解析システムは、日・欧・米、の当局に見られることがあるのか？あるいは実績はあるのか？
  1. FDAの場合、GMPなどのPredicate Rulesに対して、重大な不適合があれば、相応の法的執行手段が適用されることがあります。
    ・FDA-483 Form（規制不適合等の指摘事項）
    ・Warning Letter
    ・ライセンスの一次停止･取り消し
    ・差止め
    ・押収
    ・輸入制限
    ・告訴/民事刑罰
    このうち上2つに関しては、あらかじめわかりますが、その他は予告なく突然実施されます。
    新薬の承認審査の場合も同様で、申請却下などの措置が行われる可能性があります。

    統計解析システムは、当然当局の信頼性調査における関心事ですので、調査される可能性があります。
    FDAでは、査察時に臨床試験の再現（この場合は再解析の実施）を求める場合があります。申請したデータがどのように導き出されたかを常に記録しておかなければなりません。さらにFDAは、申請されたデータをもとに、FDA自身が製薬企業と同等またはそれ以上の解析を実施することがあります。そのため、1995年当時はCANDAといって、コンピュータによる新薬申請（解析ツールごと申請する）が試みられました。

上へ戻る

  1. 単純な（マクロなどない）Wordの文書はタイプライタエクスキューズが言えますか？
  1. 残念ながら言えません。
    まずタイプライターイクスキューズをよく理解してください。
    タイプライターイクスキューズとは、Part11査察の際に製薬企業が『真の記録は紙の記録である。我々はコンピュータを単に記録を作成するために使っているに過ぎない。』 と主張したことを指します。これに対してFDAは『たとえば電子記録が作成されない場合のように、コンピュータが本当にタイプライターのように使用されている時のみ、Part 11は適用されない。』 と答えたわけです。
    タイプライターとWordの文書の違いは、電子記録を保持するかしないかです。つまり電子記録を保持する場合は、改ざんできる可能性があります。
    ただし、当該文書がどのようなものかによって、対応は異なります。あくまでもFDAに申請する文書や、法律やGMPなどのPredicate Rulesで保存が義務つけられている文書・記録が対象です。つまり製品の安全性（Safety）、有効性（Efficacy）、品質（Quality）に直接または間接的に影響を与える文書・記録が対象です。このようなデータをGxPデータと呼びます。

上へ戻る

  1. EDC
  • EDCのバリデーションで施設側のPC上でのバリデーションは必要ないのですか？現実的に難しいと思いますが、どのように解釈すればよいのでしょうか？
  • 例えばモニターさんが検査会社から検査データを入手し、Excelに読み込み、Excelのグラフを作成し、CRFの修正、何らかの逸脱報告書などの提出を促す為にExcelのグラフ資料を提示している場合、バリデーションは必要という解釈で正しいですか？その際監査証跡は必要ですか？
  • 臨床検査データについて、医療機関での紙の検査結果（原本）と会社へ提供された電子データ（解析に利用）検査結果（原本でない）の一致性の確認はどのようにするか？というPMDAからの質問へはどのように回答すべきか？
  • プレゼン資料P14、H18.9.21付課長通知（記録の保存等　第26条1項）3. 6) 「データの修正を行う権限を与えられた者の名簿を作成し管理すること」とあるが、この名簿がEDCを利用する際の署名印影一覧に該当するものになるのか？具体的にはどういうものか？何が盛り込まれていなければならないか？
  1. EDCを一般的なWebブラズザで使用する場合、バリデーションはほとんど不要です。ただし、施設のネットワーク等のインフラ、使用しているPCのOSやブラウザのバージョン等の環境を事前調査しておく必要があります。つまり安定稼働が可能であることの確認というバリデーションを行います。ちなみに環境がそぐわない（相違がある）場合は、治験依頼者からPC等を貸し出すのが通例です。

    当該Excelは、あくまでもツールであり、申請資料や必須文書に添付されるものではありませんので、バリデーションは必ずしも必要ではありません。ただし、規制リスクはなくとも、もしバグなどの不具合があった場合、当該医療機関などに迷惑がかかることが予想されますので、それなりの品質確認はしておくべきでしょう。

    臨床検査データの紙と電子の一致は、医療機関に赴き実施するSDVにより確認しなければなりません。

    「データの修正を行う権限を与えられた者の名簿を作成し管理すること」は、 EDCを利用する際の「アカウント管理表」に相当します。
    紙媒体によるCRF運用時と異なる点として、署名印影一覧は、治験責任医師等の医療機関関係者のみであるのに対して、EDCの場合は、依頼者側のモニターやDMなどのユーザも含まれる点です。

上へ戻る

  1. QC、QA
  • 電子データのQC、QAのポイントについて
  • （電子カルテの場合の）QC、QAのポイントについて
  • GAMP5対応とQAの役割について、GAMP5に対応してCSV QA活動の合理的な実践を考慮していますがQA部門の関与の程度（頻度、深度）と必要性（どこまで直接的に関与する必要があるか）についてご教授願います。
  1. まずQCとQAの相違をよく認識してください。多くの場合、QAの人もチェックを繰り返し、「監査」のみを行っていることが多いです。
    一般に、品質管理（QC）とは、顧客の要求を満足させる品質をもった製品を作り出し、顧客に提供する機能を言います。
    日本の製薬企業において、QCは「品質をチェック」することと勘違いされている傾向があるように思われます。QCはQuality Controlの略であり、Quality Checkではありません。
    多くの製薬企業においては、データの入力に際して、ダブルエントリーを用い、また読みあわせを数回行うなどして入力ミス等を修正していますが、この作業はあくまでもCheckでありControlではありません。
    QC担当者の役割は、業務プロセスがSOP（標準）から逸脱した（またはしそうな）場合において、それを指摘し、正しいプロセスへと誘導（Control）することです。けっしてデータの入力ミスを見つけてあげることではありません。
    一般にデータの入力ミスを入力に責任を持つ者ではなく、他の者（この場合はＱＣ部門）が修正すると、プロセス中のデータの品質は向上しにくくなります。Checkだけではなく、Controlすることにより品質は向上します。
    原則は、データソース側がデータの品質に責任を持つことです。
    では品質保証（QA）は何かというと、品質にいわゆる「お墨付き」を与えることです。利害関係のない第三者が見て、確かに要求される品質が達成できているという証拠を元に、保証を行うのです。
    日本ではQAは監査（Audit）に重点が置かれています。QAはQuality Assuranceの略であり、Quality Auditではありません。
    監査は、事後に抜き取りによってCheckと指摘が行われるのが一般的です。この方法では、非監査部門が行ったCheckを繰り返していることになります。海外から、日本ではQA部門もQCを行っていると揶揄されることもあると聞きます。皮肉にも日本の製薬企業が新薬申請に使用するデータは、Checkを繰り返し行っていることから、世界で最も品質が高いとされています。しかしながら、その品質保証が十分でないと指摘されているのです。
    品質保証において重要なことは、偶然性の排除であるといえます。「たまたまやったら、たまたま良いものができた。」ではいけません。たとえ結果的に品質が良かったとしても、それでは品質保証にはならないのです。
    まず計画をたて、計画に従って緻密な作業を行い、あらかじめ決めたスペックの製品（結果）を作り出すということが、品質保証の根本的な考え方です。
    何回実行しても、同じ規格（同じ性能）の品質が得られないといけません。つまり再現性がないといけないのです。QAの実施は、利害関係のない第三者の観点から、当該業務を規制要件、自社のポリシー、手順書等と照らし合わせて適宜レビュすることです。プロセスの終了後に監査を行い、不足事項や間違いを指摘しても、品質は向上しないばかりか、品質保証にはなりません。QA部門は、適宜業務の節目毎に、プロセスの品質にお墨付き（保証）を与えることが大切といえます。
    QA担当者で、文章の「てにをは」のみを修正している人がいますが、本末転倒です。QA担当者の要件は、物事を第三者的に観察でき、ロジカルに問題点・課題点の抽出と原因究明および解決策の提示ができなければなりません。

上へ戻る

  1. デジタル署名
  • P13のスライドでタイムスタンプの説明がありましたが、デジタル署名したものに認証局のタイムスタンプを押した場合、デジタル署名が無効になることはないのでしょうか。デジタル署名の説明の際に「少しでもいじったらデジタル署名は無効になる」とおっしゃっていたので。
  1. 当日はわかりやすく大雑把にお話ししたまでです。タイムスタンプ局には実際の電子署名が付されたデジタル文書自体は送信しません。あるアルゴリズムで計算された結果ファイルを送信し、それに対してタイムスタンプ（時刻証明）を付与してもらいます。

上へ戻る

  1. その他
  • スライド14、H18.9.21 really ?
  1. Really　（＾ｕ＾）
    平成20年10月1日の課長通知にも同文で記載があります。

上へ戻る

Related post

Comment

  1. What’s up i am kavin, its my first time to commenting anyplace,
    when i read this piece of writing i thought i could also create comment due to this good post.

  2. I know this if off topic but I’m looking into starting my own weblog and was wondering what all is required to get set up?

    I’m assuming having a blog like yours would cost a pretty penny?

    I’m not very internet smart so I’m not 100% certain. Any suggestions or advice would be greatly appreciated.
    Appreciate it

  3. Hey there! This is my 1st comment here so I just wanted to give a quick
    shout out and tell you I genuinely enjoy reading your posts.
    Can you suggest any other blogs/websites/forums that deal with the same topics?
    Thank you!

  4. Fastidious answer back in return of this issue with real arguments and describing the whole
    thing regarding that.

  5. An intriguing discussion is worth comment. I think
    that you ought to write more about this subject matter,
    it might not be a taboo subject but typically people don’t speak about such subjects.

    To the next! Best wishes!!

  6. Hi to every body, it’s my first pay a visit of this website; this webpage carries
    awesome and truly excellent information in support of readers.

  7. Sweet blog! I found it while browsing on Yahoo News.

    Do you have any suggestions on how to get listed in Yahoo News?
    I’ve been trying for a while but I never seem to get there!
    Thank you

  8. Hey! This is kind of off topic but I need some guidance from an established blog.
    Is it difficult to set up your own blog? I’m not very techincal
    but I can figure things out pretty quick. I’m thinking
    about making my own but I’m not sure where to begin. Do you
    have any tips or suggestions? With thanks

  9. Hey There. I found your blog using msn. This is a very well written article.
    I’ll be sure to bookmark it and come back to read more of your useful info.

    Thanks for the post. I will definitely comeback.

  10. This site was… how do I say it? Relevant!! Finally I’ve found
    something which helped me. Appreciate it!

  11. I could not refrain from commenting. Perfectly written!

  12. Hey! I know this is kinda off topic nevertheless I’d figured I’d ask.
    Would you be interested in trading links or
    maybe guest writing a blog post or vice-versa? My site goes over a lot of the same topics as yours and
    I believe we could greatly benefit from each other. If you might be interested feel free to shoot me an e-mail.
    I look forward to hearing from you! Terrific blog by the way!

  13. Sweet blog! I found it while browsing on Yahoo News.

    Do you have any tips on how to get listed in Yahoo News?
    I’ve been trying for a while but I never seem to get there!
    Appreciate it

  14. I am genuinely grateful to the owner of this site who
    has shared this fantastic post at at this time.

  15. It’s appropriate time to make a few plans for the longer term and it’s time to
    be happy. I’ve read this publish and if I may I wish to suggest you few fascinating issues
    or suggestions. Perhaps you can write next articles relating to this article.
    I want to read more things about it!

  16. Every weekend i used to pay a visit this site, because i wish for enjoyment, since
    this this website conations really fastidious funny information too.

  17. Awesome blog you have here but I was curious about if you knew of any discussion boards that cover
    the same topics discussed in this article? I’d really love to be a part of community where I can get opinions from
    other knowledgeable people that share the same interest.

    If you have any suggestions, please let me know.
    Thanks!

  18. Can I simply say what a comfort to find somebody who
    genuinely understands what they’re discussing on the net.
    You actually know how to bring a problem to light
    and make it important. A lot more people ought to check this out and understand this side of your story.
    I was surprised that you are not more popular because you most certainly have the
    gift.

  19. Hey! Do you know if they make any plugins to safeguard against hackers?
    I’m kinda paranoid about losing everything I’ve worked
    hard on. Any tips?

  20. Hi there friends, fastidious article and good urging commented here, I am really enjoying by these.

  21. Great beat ! I wish to apprentice whilst you amend your site, how
    could i subscribe for a blog site? The account helped me a acceptable
    deal. I had been a little bit familiar of this your broadcast offered shiny
    clear concept

  22. My family always say that I am wasting my time here at web, but I know I am getting experience daily by reading such good articles or reviews.

  23. I enjoy reading an article that can make people think.
    Also, thank you for allowing me to comment!

  24. I used to be able to find good info from your blog articles.

  25. I enjoy reading an article that will make people think.
    Also, thank you for allowing me to comment!

  26. Hi, Neat post. There’s a problem together with your web site in web explorer, might test this?

    IE still is the marketplace chief and a large part of other folks
    will pass over your fantastic writing due to
    this problem.

  27. What’s up colleagues, how is the whole thing, and what you want to say concerning this piece
    of writing, in my view its actually remarkable for me.

  28. My brother recommended I may like this web site. He was entirely right.

    This publish truly made my day. You cann’t believe just how a lot
    time I had spent for this info! Thank you!

  29. hi!,I love your writing very a lot! proportion we communicate more about your article on AOL?
    I require a specialist on this area to unravel my
    problem. May be that is you! Taking a look ahead to see you.

  30. Paragraph writing is also a excitement, if you be familiar with after
    that you can write or else it is complex to write.

  31. Hello, i think that i saw you visited my website so i came to “return the favor”.I’m trying
    to find things to improve my website!I suppose its ok to use a few of your ideas!!

  32. I really like reading a post that will make people think.

    Also, many thanks for allowing for me to comment!

  33. Hey there! I realize this is somewhat off-topic however I had to ask.
    Does building a well-established blog like yours require a large amount of work?
    I’m brand new to blogging however I do write in my journal everyday.

    I’d like to start a blog so I can share my own experience and views online.
    Please let me know if you have any kind of ideas or tips
    for new aspiring bloggers. Thankyou!

  34. I’m no longer positive where you are getting your information, but good topic.
    I needs to spend a while finding out much more or working out more.

    Thank you for excellent information I was searching for this information for my mission.

  35. Hello There. I discovered your weblog the usage of msn.
    That is a really neatly written article.
    I will make sure to bookmark it and return to learn extra of your helpful information.
    Thanks for the post. I will certainly return.

  36. Pretty nice post. I just stumbled upon your blog and wished to
    say that I have really enjoyed surfing around
    your blog posts. After all I’ll be subscribing to your feed and I hope you write
    again very soon!

  37. Yes! Finally something about glow4d.

  38. Thanks for sharing such a pleasant opinion, paragraph is good,
    thats why i have read it entirely

  39. You will not have to manually resolve those pesky CAPTCHAs,
    allowing your projects to run efficiently around the clock.

    My blog Cyril

  40. I am genuinely grateful to the owner of this website who has
    shared this fantastic paragraph at at this place.

  41. What a stuff of un-ambiguity and preserveness of
    precious know-how concerning unexpected feelings.

  42. Thank you a bunch for sharing this with all folks you really know what you’re speaking approximately!
    Bookmarked. Kindly also talk over with my web site =).
    We will have a link alternate arrangement among us

  43. Useful information. Fortunate me I discovered your website accidentally, and I’m
    surprised why this accident did not happened earlier!
    I bookmarked it.

  44. Adequate ventilation and cooling are vital for preventing MG sets from overheating.
    Keeping these components cool extends their lifespan and
    ensures smooth elevator operations.
    Performing repairs promptly can help extend an elevator’s lifespan.

    Here is my web-site: elevator preventative maintenance

  45. Your style is really unique compared to other people I have read stuff from.

    Thanks for posting when you’ve got the opportunity, Guess I’ll just bookmark this page.

    Feel free to surf to my website :: 263 san ao soup (http://www.udianinfo.com)

  46. Hi friends, how is all, and what you desire to say regarding
    this article, in my view its actually amazing in favor of me.

    Also visit my web-site – 188 เครดิตฟรี

  47. Good day! I could have sworn I’ve been to this
    site before but after browsing through some of
    the post I realized it’s new to me. Anyhow, I’m
    definitely delighted I found it and I’ll be book-marking and checking back
    often!

  48. This is a great breakdown of CNC machining reliable sources for hydraulic components hydraulic components.
    As a professional in the fluid power industry, I’ve witnessed the exactness these processes
    bring to our parts.

  49. The efficiency of Mantle 3D in lowering lead times from
    prototype to production could help manufacturers adapt
    more quickly to market demands.

    The integration of additive and subtractive processes in Mantle’s
    3D technology is brilliant.

    Being able to include complex features into a single tool could simplify the manufacturing process
    greatly, cutting the need for multiple components.

  50. At this time I am going away to do my breakfast, later than having my breakfast coming over again to
    read other news.

    Feel free to visit my web blog: คาสิโนออนไลน์ สล็อต

  51. I am no longer positive the place you are getting your info, however good topic.
    I must spend a while learning much more or understanding more.
    Thanks for excellent information I used to be in search of this
    info for my mission.

    Stop by my blog: เครดิตฟรี 50 ยืนยันเบอร์โทร 2023

  52. https://solo.to/kobet1

  53. Coming again to online purchasing for lingerie, we discover that lingerie figures solely subsequent
    to books because the product that is most purchased online right here.

    Our aim is to create a product choice that encompasses all
    life occasions. Explore Fashionfitz’s curated selection of lingerie for triangle body varieties.
    Lovely ladies, we hope you got an idea of what your physique sort
    is and which fashion will look greatest on you. In the next
    blog publish we are going to discover out which brands provide the highest discounts
    and have a look at some additional attention-grabbing
    findings. Whereas our florists make every effort to create precisely the identical bouquet as proven, it can possible look a bit totally different since we
    might have to substitute with a similar flower and/or colour.
    Resulting from its prismatic palette, shade may fluctuate. The utmost care and a
    spotlight shall be given to your order to make sure that
    it is as similar as possible to the requested merchandise.
    Just a observe, in case you have very thin bridesmaids, these will in all probability be huge, even when squeezed to
    make as small as possible. Subsequently, should you perform a thorough
    research, it is feasible for you to to pick the suitable colors and
    designs that go well with your specific needs.

  54. Wow that was unusual. I just wrote an very long comment but after I
    clicked submit my comment didn’t appear. Grrrr… well I’m not
    writing all that over again. Anyway, just wanted to say superb blog!

    Also visit my website: 98 gaming online casino philippines

  55. https://www.outlookindia.com/plugin-play/ED8590ED8590EBB2B3-EB8F99EC9DBC-EC8694EBA3A8EC8598-EBA994EC9DB4ECA080EC82ACEC9DB4ED8AB8-EBAAA8EC9584EBB3B4EAB8B0

  56. http://guardian.startlawyer.co.kr/bbs/board.php?bo_table=free&wr_id=83138

  57. http://www.freelaw21.co.kr/pg/bbs/board.php?bo_table=free&wr_id=150700

  58. http://healing-town.kr/bbs/board.php?bo_table=free&wr_id=52737

  59. Can I simply just say what a comfort to discover a peerson that genuinely understands what they’re talking about on the internet.

    You definitely ujderstand how too bring an issue tto light and make
    it important. More people really need to read
    this and understaqnd this side of the story. I can’t believe youu aren’t mire popular beause you definitely
    possess the gift.

    Alsso visit my web site: hire movers

  60. Good post. I learn something totally new and challenging on sites I stumbleupon on a daily basis.
    It will always be useful to read content from other
    authors and use a little something from other sites.

  61. https://fromkorea.kr/kor/bbs/board.php?bo_table=free&wr_id=2

  62. Awesome article.

    My website; Baskı beton

  63. Nice post. I was checking continuously this blog
    aand I’m impressed! Very useful info speciallly the
    ultkmate phase 🙂 I take care of such information a lot.

    I used to be seeking this particular info for a veey lenhthy time.
    Thank you and best of luck.

    Also visit my website: Audac

  64. Every weekend i used to pay a quick visit this web site,
    because i wish for enjoyment, as this this web page conations in fact nice funny data too.

  65. My spose and I absolutely love your blog and find most of your
    post’s to be exactly I’m looking for. can youu offer guest writers to write content for you personally?
    I wouldn’t mind composing a post or elaborating on many of the subjects you write about
    here. Again, awesome site!

    Here is my blog tanıtım filmi çekimi

  66. Hi there, this weekend is fastidious in support of me, as this occasion i am reading this
    impressive educational paragraph here att my house.

    Visit my hoomepage :: Ankara icra avukatı

  67. I’d forever want to be update on new content on this website, bookmarked!

    My web site – http://WWW.Fukushima.st/mff/bbs/bbs.cgi/www.clubrand.com/fl-218-b0/www.clubrand.com/fl-218-b0/bbs/bbs/bjmggwylwluyhkz

  68. I always used to study piece of writing in news papers but now as I am a user of web thus from now I am using net for posts, thanks to web.

    Here is my website :: http://Old.Amerit.org.mk/question/how-to-decide-an-online-casino-26/

  69. My brother suggested I might like this website. He was entirely
    right. This post actually made my day. You can not imagine
    just how much time I had spent for this info! Thanks!

  70. I’m extremely impressed with your writing skills and also with the layout on your weblog.
    Is this a paid theme or did you modify it yourself?
    Anyway keep up the nice quality writing, it’s rare to
    see a nice blog like this one today.

  71. Hello friends, good post and good urging commented here, I am in fact enjoying by these.

  72. You actually make it seem so easy with your presentation but I
    find this topic to be actually something that I think I would never understand.
    It seems too complicated and very broad for me. I’m looking forward for your next post,
    I will try to get the hang of it!

  73. Hi my friend! I want to say that this post is amazing, nice
    written and include almost all important infos. I’d like to peer more posts
    like this .

  74. Heya! I’m at work surfing around your blog from my new iphone!
    Just wanted to say I love reading through your blog and look forward
    to all your posts! Keep up the great work!

  75. I’m impressed, I have to admit. Seldom do I encounter a blog that’s
    equally educative and engaging, and without a doubt, you have hit the nail on the head.

    The issue is something not enough folks are speaking intelligently about.
    I am very happy that I found this during my hunt for something
    regarding this.

  76. Ahaa, its good discussion concerning this piece of writing here
    at this web site, I have read all that, so now me also commenting here.

  77. My brother suggested I might like this web site.
    He was once entirely right. This put up actually made my day.
    You can not consider just how a lot time I had spent for this info!

    Thank you!

  78. Why viewers still make use of to read news
    papers when in this technological world the whole thing is presented on web?

  79. It’s an amazing article designed for all the internet visitors;
    they will obtain benefit from it I am sure.

  80. I read this post fully on the topic of the difference of hottest and previous technologies, it’s awesome article.

  81. Wow, marvelous blog format! How long have you been blogging for?
    you made blogging look easy. The entire glance of your website is fantastic, let alone the content!

  82. Thanks for sharing such a pleasant opinion, piece
    of writing is fastidious, thats why i have read it entirely

  83. Hi, i believe that i noticed you visited my web site
    thus i came to return the favor?.I am trying to to find issues to enhance my
    site!I suppose its good enough to use some of your ideas!!

  84. Hello, i think that i noticed you visited my blog thus i got here to return the favor?.I’m trying to in finding things to improve my web site!I suppose
    its adequate to use some of your ideas!!

  85. Wow, awesome blog layout! How long have you been blogging for?

    you made blogging look easy. The overall look of
    your web site is excellent, as well as the content!

  86. Very good blog! Do you have any tips and hints for aspiring writers?
    I’m hoping to start my own blog soon but I’m a little lost on everything.
    Would you suggest starting with a free platform
    like WordPress or go for a paid option? There are so many options
    out there that I’m totally confused .. Any tips? Many thanks!

  87. Very shortly this website will be famous among all blogging and site-building visitors, due to it’s pleasant
    content

  88. Fantastic goods from you, man. I have take into
    accout your stuff previous to and you’re just extremely magnificent.
    I really like what you have obtained right here,
    really like what you’re saying and the way in which wherein you say it.

    You’re making it enjoyable and you still take
    care of to keep it wise. I cant wait to learn much more from you.
    That is actually a tremendous website.

  89. I’m not positive the place you are getting your information, however great topic.

    I needs to spend some time finding out more or figuring out more.
    Thank you for wonderful information I was in search of
    this information for my mission.

  90. Link exchange is nothing else however it is only placing the other person’s web site link on your page
    at proper place and other person will also do similar in support of
    you.

  91. I like what you guys are usually up too. This kind of clever work and exposure!
    Keep up the very good works guys I’ve added you guys to our blogroll.

  92. I visited many web pages however the audio feature for
    audio songs existing at this website is in fact superb.

  93. There is certainly a lot to learn about this subject.
    I love all the points you made.

  94. Hello, i read your blog from time to time and i own a similar one and i was just curious if you
    get a lot of spam responses? If so how do you stop it, any plugin or anything you can advise?

    I get so much lately it’s driving me insane so any support
    is very much appreciated.

  95. Right here is the perfect blog for anyone who wants to find out about this topic.

    You know so much its almost tough to argue with you (not that
    I really will need to…HaHa). You certainly put a fresh spin on a
    topic that’s been written about for ages. Great
    stuff, just excellent!

  96. Very good info. Lucky me I recently found your site by accident (stumbleupon).
    I have book-marked it for later!

  97. Hey there! I just wanted to ask if you ever have any trouble with
    hackers? My last blog (wordpress) was hacked and I ended up losing several weeks of hard work
    due to no back up. Do you have any methods to prevent hackers?

  98. Normally I don’t read post on blogs, however I wish to say
    that this write-up very forced me to take a look at and
    do it! Your writing style has been amazed me.
    Thank you, quite great post.

  99. What i don’t realize is in truth how you’re now not actually
    much more smartly-favored than you might be right now.
    You are very intelligent. You realize thus considerably in the
    case of this subject, produced me in my view imagine it from so many numerous angles.
    Its like men and women aren’t fascinated except it’s something to accomplish with Girl gaga!

    Your personal stuffs great. Always maintain it up!

  100. Just wish to say your article is as amazing. The clearness in your
    post is just nice and i could assume you’re an expert on this subject.
    Fine with your permission allow me to grab your RSS feed to keep up to
    date with forthcoming post. Thanks a million and please continue the rewarding work.

  101. Hi! I realize this is sort of off-topic but I had to
    ask. Does managing a well-established website such as yours require a large amount of work?
    I am brand new to writing a blog however I do write in my
    journal every day. I’d like to start a blog so I can easily share my personal experience and feelings online.

    Please let me know if you have any ideas or tips for new aspiring bloggers.
    Thankyou!

  102. Wow, superb blog layout! How long have you been blogging for?
    you made blogging look easy. The overall look of your web site is excellent, as well
    as the content!

  103. Thank you a lot for sharing this with all folks you actually recognize what you are speaking about!
    Bookmarked. Please also talk over with my site =). We may have a
    hyperlink trade agreement between us

  104. I pay a quick visit every day some websites and
    sites to read articles, but this weblog provides quality based writing.

  105. Hi there, I found your blog by way of Google at the same
    time as searching for a comparable matter, your site came up, it looks great.
    I’ve bookmarked it in my google bookmarks.
    Hi there, just was aware of your weblog through Google,
    and located that it is truly informative.

    I’m going to watch out for brussels. I will be grateful if you happen to continue this in future.
    Lots of folks will likely be benefited out of your writing.
    Cheers!

  106. Hello! I just want to offer you a big thumbs up for the excellent information you have
    got here on this post. I’ll be coming back to your website for more soon.

  107. Hello friends, its wonderful piece of writing regarding
    tutoringand fully explained, keep it up all the time.

  108. Hi there to all, as I am truly keen of reading this website’s
    post to be updated on a regular basis. It consists of good data.

  109. Can I just say what a comfort to uncover someone that truly knows what they’re
    discussing over the internet. You definitely realize how to bring a
    problem to light and make it important. More and more people have to read this and understand this
    side of your story. I can’t believe you’re not more popular because you most certainly have the gift.

  110. Your style is so unique in comparison to other folks I’ve read
    stuff from. Thanks for posting when you have the opportunity, Guess I will just book mark this blog.

  111. Today, while I was at work, my sister stole my
    apple ipad and tested to see if it can survive a
    twenty five foot drop, just so she can be a youtube sensation. My iPad is now
    broken and she has 83 views. I know this is totally off topic
    but I had to share it with someone!

  112. You’re so cool! I don’t suppose I have read through anything like that before.
    So wonderful to discover someone with some genuine thoughts on this
    issue. Really.. many thanks for starting this up.
    This web site is one thing that’s needed on the
    internet, someone with a bit of originality!

  113. It’s nearly impossible to find experienced people
    in this particular topic, but you sound like you know what you’re talking about!
    Thanks

  114. Touche. Outstanding arguments. Keep up the great spirit.

  115. Excellent, what a website it is! This web site presents valuable facts to us, keep it up.

  116. Fantastic beat ! I wish to apprentice while you amend your
    web site, how can i subscribe for a blog site?
    The account helped me a acceptable deal. I had been a little
    bit acquainted of this your broadcast provided bright clear idea

  117. A motivating discussion is worth comment. I do believe that you ought to publish more on this issue,
    it may not be a taboo subject but generally people do
    not talk about these issues. To the next! Best wishes!!

  118. Good day! I know this is kinda off topic nevertheless I’d figured I’d ask.
    Would you be interested in trading links or maybe guest
    writing a blog post or vice-versa? My site covers a lot of the same topics as yours and I think we could greatly
    benefit from each other. If you are interested
    feel free to send me an e-mail. I look forward to hearing from you!
    Excellent blog by the way!

  119. Excellent beat ! I would like to apprentice even as you amend your web site, how could i subscribe for a weblog site?
    The account aided me a acceptable deal. I had been a little bit acquainted of this your broadcast provided vivid transparent concept

  120. It’s awesome for me to have a web site, which is helpful in favor of my know-how.
    thanks admin

  121. I blog frequently and I genuinely thank you for your information. The article has truly peaked my
    interest. I will take a note of your website and keep checking for new information about once per week.

    I subscribed to your Feed too.

  122. It’s in fact very complicated in this full of activity life to listen news on Television, so I simply use web
    for that reason, and get the most recent news.

  123. Hi would you mind stating which blog platform you’re
    using? I’m going to start my own blog soon but I’m having a difficult time
    making a decision between BlogEngine/Wordpress/B2evolution and Drupal.
    The reason I ask is because your design seems different then most blogs and I’m looking for
    something unique. P.S Sorry for getting off-topic but I had to ask!

  124. In fact no matter if someone doesn’t understand after that its up to other viewers that they will help, so
    here it occurs.

  125. I don’t even understand how I stopped up here, however I assumed
    this put up was once great. I don’t recognize who you’re
    however definitely you are going to a well-known blogger if you
    happen to aren’t already. Cheers!

  126. It’s going to be finish of mine day, except before finish I am reading this fantastic article
    to improve my know-how.

  127. I’ve been browsing on-line greater than three hours lately, but I never discovered any interesting article like yours.
    It’s lovely value enough for me. Personally, if all web owners and bloggers made good content material as you probably did, the web will be much more helpful than ever
    before.

  128. Hi there mates, how is everything, and what you want to
    say regarding this article, in my view its genuinely remarkable designed for me.

  129. I loved as much as you will receive carried out right here.

    The sketch is tasteful, your authored subject
    matter stylish. nonetheless, you command get bought an shakiness over
    that you wish be delivering the following. unwell unquestionably come
    more formerly again since exactly the same nearly a lot often inside case you shield this hike.

  130. Hey! This post could not be written any better!
    Reading this post reminds me of my previous room mate!

    He always kept chatting about this. I will forward this page to him.
    Pretty sure he will have a good read. Thanks for
    sharing!

  131. Hi there! Do you know if they make any plugins
    to safeguard against hackers? I’m kinda paranoid about losing everything
    I’ve worked hard on. Any suggestions?

  132. What’s up Dear, are you in fact visiting this website regularly,
    if so afterward you will without doubt get nice experience.

  133. Hey there this is kind of of off topic but
    I was wanting to know if blogs use WYSIWYG editors or if
    you have to manually code with HTML. I’m starting a blog soon but have no coding know-how so I wanted to get advice from someone with experience.
    Any help would be enormously appreciated!

  134. Wonderful post! We are linking to this great article on our site.

    Keep up the good writing.

  135. Hey! I know this is sort of off-topic however I had to ask.
    Does building a well-established website such as yours
    require a large amount of work? I am completely new
    to blogging but I do write in my diary everyday.
    I’d like to start a blog so I can easily share my experience and feelings online.
    Please let me know if you have any suggestions or tips for new aspiring bloggers.
    Appreciate it!

  136. Thanks to my father who shared with me regarding this web site,
    this web site is in fact remarkable.

  137. Thank you for the good writeup. It in fact was a amusement account it.
    Look advanced to more added agreeable from you!
    By the way, how can we communicate?

  138. If you would like to obtain a great deal from this article then you have to apply these methods to your
    won weblog.

  139. Awesome article.

  140. It’s actually very complex in this busy life to listen news on Television, so I just use the web for that purpose, and take the most up-to-date
    information.

  141. There’s definately a great deal to know about this subject.
    I really like all the points you’ve made.

  142. I am no longer positive where you’re getting your
    information, but great topic. I must spend a while learning more or understanding more.
    Thanks for fantastic information I was searching for this information for my mission.

  143. I’m not that much of a online reader to be honest but your blogs really nice, keep
    it up! I’ll go ahead and bookmark your site to come back down the road.
    Cheers

  144. Hi there just wanted to give you a quick heads up. The text in your post
    seem to be running off the screen in Internet explorer.

    I’m not sure if this is a format issue or something to do with browser compatibility but I thought I’d post to let you know.
    The design look great though! Hope you get the issue solved soon. Cheers

  145. The other day, while I was at work, my sister stole my iPad and
    tested to see if it can survive a 30 foot drop, just so she
    can be a youtube sensation. My apple ipad is now destroyed and
    she has 83 views. I know this is entirely off topic but I had to share it with someone!

  146. I’ve been surfing on-line greater than three hours lately, but I
    by no means discovered any interesting article
    like yours. It’s lovely price sufficient for me. In my view, if
    all site owners and bloggers made good content material as you probably did, the internet will be a lot
    more useful than ever before.

  147. It’s very straightforward to find out any matter on web as compared to books, as I found this
    paragraph at this website.

  148. I am truly thankful to the holder of this site who has shared this wonderful post at at this time.

  149. Hmm it appears like your site ate my first comment (it was super long) so I guess I’ll just
    sum it up what I wrote and say, I’m thoroughly enjoying
    your blog. I too am an aspiring blog blogger but I’m
    still new to the whole thing. Do you have any tips and hints for first-time blog writers?
    I’d definitely appreciate it.

  150. Great site you’ve got here.. It’s difficult to find high-quality writing like yours these days.
    I truly appreciate individuals like you! Take care!!

  151. If some one wants expert view about blogging and site-building after
    that i recommend him/her to visit this weblog, Keep up the good work.

  152. I’m extremely inspired with your writing talents as smartly
    as with the structure to your weblog. Is that this a paid subject
    matter or did you customize it yourself? Either way keep
    up the nice high quality writing, it is rare to look a nice blog like this one these days..

  153. I have been surfing on-line more than three hours lately, but I by no means discovered any attention-grabbing article like yours.
    It is lovely price sufficient for me. In my opinion, if all webmasters and bloggers made just right content as
    you did, the net shall be a lot more useful than ever before.

  154. I like the helpful info you provide on your articles. I will bookmark your blog and take a look at once more right here frequently.
    I’m rather sure I’ll be told a lot of new stuff right here!

    Best of luck for the next!

  155. Hello to every one, for the reason that I am genuinely
    keen of reading this website’s post to be updated daily.
    It carries pleasant material.

  156. Hello, constantly i used to check blog posts
    here early in the morning, because i enjoy to find out more
    and more.

  157. Everything is very open with a precise description of the issues.

    It was really informative. Your website is extremely helpful.
    Many thanks for sharing!

  158. I’m not positive the place you are getting your info, but good topic.
    I needs to spend some time learning more or working out more.
    Thank you for great information I used to be in search of this information for my mission.

  159. Hey I know this is off topic but I was wondering if you knew of any widgets
    I could add to my blog that automatically tweet my newest twitter updates.
    I’ve been looking for a plug-in like this for quite some time and was hoping maybe
    you would have some experience with something like this.
    Please let me know if you run into anything. I truly enjoy reading your blog and I look
    forward to your new updates.

  160. I really like what you guys are up too. This sort of clever work and
    exposure! Keep up the very good works guys I’ve included you guys
    to blogroll.

  161. Someone essentially lend a hand to make critically posts I’d state.
    That is the very first time I frequented your website page
    and to this point? I surprised with the analysis
    you made to make this actual publish amazing. Magnificent task!

  162. Appreciate this post. Will try it out.

  163. bookmarked!!, I love your site!

  164. Hi there to all, how is everything, I think every one is getting more from this web page, and your views are good in support of new
    people.

  165. Thank you for the auspicious writeup. It in fact was a amusement account it.
    Look advanced to more added agreeable from you!
    However, how can we communicate?

  166. Simply desire to say your article is as astounding. The clarity in your put up is simply great and i could assume you are an expert in this subject.
    Fine along with your permission let me to snatch your
    RSS feed to stay up to date with imminent post.

    Thank you a million and please continue the gratifying work.

  167. I blog often and I genuinely thank you for your information. The article
    has really peaked my interest. I will take a note of your blog and keep
    checking for new details about once a week. I subscribed to your RSS feed as
    well.

  168. This is very interesting, You’re a very skilled blogger.
    I have joined your feed and look forward to seeking more of your
    magnificent post. Also, I’ve shared your website
    in my social networks!

  169. If you want to improve your knowledge simply keep visiting
    this web site and be updated with the most up-to-date gossip
    posted here.

  170. Hey I am so grateful I found your blog, I really found you by accident, while I was
    looking on Askjeeve for something else, Anyways I am
    here now and would just like to say cheers for a marvelous post and a all round entertaining
    blog (I also love the theme/design), I don’t have time to read through it all at the minute but I have book-marked it and
    also included your RSS feeds, so when I have time I will be back to read
    more, Please do keep up the superb work.

  171. If you are going for most excellent contents like I do, simply visit
    this site daily because it offers quality contents, thanks

  172. We’re a bunch of volunteers and starting a new scheme
    in our community. Your web site offered us with useful info to work on. You have
    done a formidable task and our whole neighborhood will probably be grateful to you.

  173. Hi there everybody, here every one is sharing such knowledge, therefore
    it’s fastidious to read this website, and I used to go to see this blog
    all the time.

  174. When I originally left a comment I appear to have clicked the -Notify me when new comments
    are added- checkbox and from now on whenever a comment is added I recieve 4 emails
    with the exact same comment. Perhaps there is a means you can remove me from that service?

    Thank you!

  175. Very soon this site will be famous among all blogging viewers, due to it’s good content

  176. Hello! This is kind of off topic but I need some
    guidance from an established blog. Is it very hard to set up
    your own blog? I’m not very techincal but I can figure things out
    pretty quick. I’m thinking about making my own but
    I’m not sure where to begin. Do you have any tips or suggestions?
    Cheers

  177. This is my first time pay a visit at here and i am genuinely
    pleassant to read all at alone place.

  178. It’s wonderful that you are getting thoughts from this piece of writing as
    well as from our dialogue made at this place.

  179. constantly i used to read smaller articles which also clear their motive, and that is also
    happening with this article which I am reading at this time.

  180. Hi, i feel that i saw you visited my web site thus i came to
    return the prefer?.I am attempting to to find things to enhance my
    web site!I guess its ok to use a few of your
    concepts!!

  181. Asking questions are really good thing if you are not understanding anything fully, however this paragraph offers fastidious understanding yet.

  182. Inspiring quest there. What happened after? Take care!

  183. Thank you a bunch for sharing this with all of us you really recognise
    what you’re speaking approximately! Bookmarked. Kindly additionally visit my site =).
    We can have a link exchange contract between us

  184. Hello, I enjoy reading all of your article post. I wanted
    to write a little comment to support you.

  185. I’ve been browsing online more than three hours today, yet I never found any interesting article like yours.
    It is pretty worth enough for me. In my view, if all
    web owners and bloggers made good content as you did, the
    net will be much more useful than ever before.

  186. Today, I went to the beach with my kids. I found
    a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She put the shell to her ear and screamed.
    There was a hermit crab inside and it pinched her ear. She never wants to go back!
    LoL I know this is completely off topic but I had to tell someone!

  187. you’re really a just right webmaster. The website
    loading velocity is incredible. It seems that
    you are doing any unique trick. Moreover, The contents are masterwork.
    you have performed a fantastic job on this subject!

  188. Hello, this weekend is nice for me, because this time i am reading this fantastic informative article here at my residence.

  189. Appreciate the recommendation. Will try it out.

  190. Hi, I do think this is an excellent web site. I stumbledupon it 😉 I am going to revisit yet again since i
    have book marked it. Money and freedom is the best way to
    change, may you be rich and continue to help other people.

  191. Touche. Outstanding arguments. Keep up the good effort.

  192. I constantly spent my half an hour to read this website’s posts daily along with a cup of coffee.

  193. I wanted to thank you for this very good read!! I certainly loved every bit of it.
    I’ve got you saved as a favorite to check out new things you post…

  194. Hurrah, that’s what I was exploring for, what a stuff!
    present here at this web site, thanks admin of this web site.

  195. Hey would you mind letting me know which web host you’re using?
    I’ve loaded your blog in 3 completely different internet browsers and I must
    say this blog loads a lot quicker then most. Can you suggest a good internet hosting provider
    at a honest price? Many thanks, I appreciate it!

  196. I enjoy what you guys are usually up too. This kind of clever work and coverage!
    Keep up the good works guys I’ve incorporated you guys
    to our blogroll.

  197. I enjoy what you guys are up too. This sort of clever work and reporting!

    Keep up the great works guys I’ve incorporated you guys
    to our blogroll.

  198. Great post however I was wanting to know if you could write a
    litte more on this topic? I’d be very grateful if you could elaborate a
    little bit more. Cheers!

  199. Thanks for the good writeup. It in fact was a enjoyment account it.
    Look advanced to more delivered agreeable from you! However, how can we
    keep in touch?

  200. Greate post. Keep writing such kind of information on your blog.
    Im really impressed by it.
    Hello there, You have done a fantastic job. I will certainly digg it and personally suggest to my friends.
    I’m sure they will be benefited from this site.

  201. It’s remarkable in support of me to have a web site, which is beneficial for my experience.

    thanks admin

  202. This post presents clear idea for the new viewers of blogging, that really how to do blogging.

  203. Thanks for a marvelous posting! I actually enjoyed reading it, you will
    be a great author.I will be sure to bookmark your blog and will often come back very soon. I want to encourage you to definitely continue your great job, have a nice morning!

  204. Hello, i think that i saw you visited my weblog
    so i came to return the desire?.I’m attempting to in finding issues to enhance my website!I assume its
    ok to use a few of your concepts!!

  205. When some one searches for his necessary thing, so he/she wishes to be available that in detail, therefore that
    thing is maintained over here.

  206. Excellent post. Keep posting such kind of information on your page.
    Im really impressed by it.
    Hi there, You have done an incredible job.

    I will definitely digg it and in my opinion suggest to
    my friends. I’m sure they’ll be benefited from this site.

  207. Thanks a lot for sharing this with all people you actually understand what you’re speaking about!
    Bookmarked. Kindly also seek advice from my web site
    =). We could have a hyperlink change agreement between us

  208. I like the valuable info you provide in your articles.

    I will bookmark your weblog and check again here frequently.
    I am quite sure I’ll learn lots of new stuff right here!
    Good luck for the next!

  209. Hey there! Someone in my Myspace group shared this site with us
    so I came to take a look. I’m definitely enjoying the information. I’m book-marking and will
    be tweeting this to my followers! Outstanding blog and terrific
    design and style.

  210. Quality posts is the main to invite the users to
    pay a quick visit the website, that’s what this web site is
    providing.

  211. It is not my first time to pay a quick visit
    this web site, i am browsing this web page dailly and take
    pleasant data from here daily.

  212. Hello it’s me, I am also visiting this site daily, this web site
    is truly pleasant and the visitors are genuinely sharing pleasant thoughts.

  213. Fantastic goods from you, man. I have understand your stuff previous to and you’re just too fantastic.
    I actually like what you’ve acquired here, really like
    what you are stating and the way in which you say it. You make it entertaining and you
    still care for to keep it sensible. I cant wait to read much
    more from you. This is really a tremendous web site.

  214. Hey! I understand this is sort of off-topic however I needed to ask.
    Does managing a well-established website such as yours require a lot of
    work? I’m brand new to blogging but I do write in my journal every day.
    I’d like to start a blog so I can share my own experience and thoughts online.
    Please let me know if you have any ideas or tips for new aspiring blog owners.
    Thankyou!

  215. Very soon this web page will be famous among all blogging viewers, due to it’s good articles or reviews

  216. That’s a nice site that we could appreciate Get more info

  217. That’s a nice site that we could appreciate Get more info

  218. That’s a nice site that we could appreciate Get more info

  219. That’s a nice site that we could appreciate Get more info

  220. That’s a nice site that we could appreciate Get more info

  221. That’s a nice site that we could appreciate Get more info

  222. That’s a nice site that we could appreciate Get more info

  223. That’s a nice site that we could appreciate Get more info

  224. That’s a nice site that we could appreciate Get more info

  225. Thanks for your marvelous posting! I truly enjoyed reading it, you may be
    a great author.I will always bookmark your blog and may come back down the road.

    I want to encourage you continue your great job, have a nice weekend!

TOP